Pseudomembranous colitis pathophysiology: Difference between revisions
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{{Pseudomembranous colitis}} | {{Pseudomembranous colitis}} | ||
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== | ==Overview== | ||
The use of broad-spectrum antibiotics such as [[clindamycin]] and cephalosporins causes the normal bacterial flora of the bowel to be altered. In particular, when the [[antibiotic]] kills off other, competing bacteria in the intestine, any bacteria remaining will have less competition for space and nutrients there. The net effect is to permit much more extensive growth than normal of certain bacteria. Clostridium difficile is one such type of bacteria. In addition to proliferating in the bowel, the C. diff also elaborates a [[toxin]]. It is this toxin that is responsible for the diarrhea which characterizes pseudomembranous colitis. | The use of broad-spectrum antibiotics such as [[clindamycin]] and cephalosporins causes the normal bacterial flora of the bowel to be altered. In particular, when the [[antibiotic]] kills off other, competing bacteria in the intestine, any bacteria remaining will have less competition for space and nutrients there. The net effect is to permit much more extensive growth than normal of certain bacteria. Clostridium difficile is one such type of bacteria. In addition to proliferating in the bowel, the C. diff also elaborates a [[toxin]]. It is this toxin that is responsible for the diarrhea which characterizes pseudomembranous colitis. | ||
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Revision as of 20:14, 28 February 2013
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Please help WikiDoc by adding content here. It's easy! Click here to learn about editing. Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The use of broad-spectrum antibiotics such as clindamycin and cephalosporins causes the normal bacterial flora of the bowel to be altered. In particular, when the antibiotic kills off other, competing bacteria in the intestine, any bacteria remaining will have less competition for space and nutrients there. The net effect is to permit much more extensive growth than normal of certain bacteria. Clostridium difficile is one such type of bacteria. In addition to proliferating in the bowel, the C. diff also elaborates a toxin. It is this toxin that is responsible for the diarrhea which characterizes pseudomembranous colitis.