Lyme disease natural history, complications and prognosis: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 10: Line 10:


Though rare, Lyme disease can be fatal.<ref name="Kirsch">{{cite journal | author=Kirsch M, Ruben FL, Steere AC, Duray PH, Norden CW, Winkelstein A | title=Fatal adult respiratory distress syndrome in a patient with Lyme disease | journal=JAMA | year=1988 | pages=2737-9 | volume=259 | issue=18 | pmid= 3357244}}</ref><ref name="Oksi-b">{{cite journal | author=Oksi J, Kalimo H, Marttila RJ, ''et al'' | title=Inflammatory brain changes in Lyme borreliosis. A report on three patients and review of literature | journal=Brain | year=1996 | pages=2143-54 | volume=119 | issue=Pt 6 | pmid= 9010017}}</ref><ref name="Waniek">{{cite journal | author=Waniek C, Prohovnik I, Kaufman MA, Dwork AJ | title=Rapidly progressive frontal-type dementia associated with Lyme disease | journal=J Neuropsychiatry Clin Neurosci | year=1995 | pages=345-7 | volume=7 | issue=3 | pmid= 7580195}}</ref><ref name="Cary">{{cite journal | author=Cary NR, Fox B, Wright DJ, Cutler SJ, Shapiro LM, Grace AA | title=Fatal Lyme carditis and endodermal heterotopia of the atrioventricular node | journal=Postgrad Med J | year=1990 | pages=134-6 | volume=66 | issue=772 | pmid= 2349186}}</ref>The first CDC recognized death from Lyme disease was Amanda Schmidt, age 11.<ref>{{ cite news | url = http://pqasb.pqarchiver.com/latimes/access/60144819.html?dids=60144819:60144819&FMT=ABS&FMTS=ABS:FT&type=current&date=Sep+26%2C+1990&author=&pub=Los+Angeles+Times+(pre-1997+Fulltext)&edition=&startpage=2&desc=HEALTH+First+Lyme+Disease+Death+Told | title = First Lyme Disease Death Told | work = Los Angeles Times | date = 1990-09-26}}</ref><!-- Need better ref, here -->
Though rare, Lyme disease can be fatal.<ref name="Kirsch">{{cite journal | author=Kirsch M, Ruben FL, Steere AC, Duray PH, Norden CW, Winkelstein A | title=Fatal adult respiratory distress syndrome in a patient with Lyme disease | journal=JAMA | year=1988 | pages=2737-9 | volume=259 | issue=18 | pmid= 3357244}}</ref><ref name="Oksi-b">{{cite journal | author=Oksi J, Kalimo H, Marttila RJ, ''et al'' | title=Inflammatory brain changes in Lyme borreliosis. A report on three patients and review of literature | journal=Brain | year=1996 | pages=2143-54 | volume=119 | issue=Pt 6 | pmid= 9010017}}</ref><ref name="Waniek">{{cite journal | author=Waniek C, Prohovnik I, Kaufman MA, Dwork AJ | title=Rapidly progressive frontal-type dementia associated with Lyme disease | journal=J Neuropsychiatry Clin Neurosci | year=1995 | pages=345-7 | volume=7 | issue=3 | pmid= 7580195}}</ref><ref name="Cary">{{cite journal | author=Cary NR, Fox B, Wright DJ, Cutler SJ, Shapiro LM, Grace AA | title=Fatal Lyme carditis and endodermal heterotopia of the atrioventricular node | journal=Postgrad Med J | year=1990 | pages=134-6 | volume=66 | issue=772 | pmid= 2349186}}</ref>The first CDC recognized death from Lyme disease was Amanda Schmidt, age 11.<ref>{{ cite news | url = http://pqasb.pqarchiver.com/latimes/access/60144819.html?dids=60144819:60144819&FMT=ABS&FMTS=ABS:FT&type=current&date=Sep+26%2C+1990&author=&pub=Los+Angeles+Times+(pre-1997+Fulltext)&edition=&startpage=2&desc=HEALTH+First+Lyme+Disease+Death+Told | title = First Lyme Disease Death Told | work = Los Angeles Times | date = 1990-09-26}}</ref><!-- Need better ref, here -->
==Complications==
Stage 3, or late disseminated, Lyme disease can cause long-term joint inflammation (Lyme arthritis) and heart rhythm problems. Brain and nervous system problems are also possible, and may include:
*Decreased concentration
*Memory disorders
*Nerve damage
*Numbness
*Pain
*Paralysis of the face muscles
*Sleep disorders
*Vision problems


==References==
==References==

Revision as of 16:13, 9 February 2012

Lyme disease Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Epidemiology and Demographics

Causes

Differentiating Lyme disease from other Diseases

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

ECG

X-ray

CT scan

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Sudies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Future or Investigational Therapies

Case Studies

Case #1

Lyme disease natural history, complications and prognosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Lyme disease natural history, complications and prognosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Lyme disease natural history, complications and prognosis

CDC on Lyme disease natural history, complications and prognosis

Lyme disease natural history, complications and prognosis in the news

Blogs on Lyme disease natural history, complications and prognosis

Directions to Hospitals Treating Lyme disease

Risk calculators and risk factors for Lyme disease natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Prognosis

For early cases, prompt treatment is usually curative.[1] However, the severity and treatment of Lyme disease may be complicated due to late diagnosis, failure of antibiotic treatment, simultaneous infection with other tick-borne diseases including ehrlichiosis, babesiosis, and bartonella, and immune suppression in the patient.

A meta-analysis published in 2005 found that some patients with Lyme disease have fatigue, joint and/or muscle pain, and neurocognitive symptoms persisting for years despite antibiotic treatment.[2] Patients with late Stage Lyme disease have been shown to experience a level of physical disability equivalent to that seen in congestive heart failure.[3]

Though rare, Lyme disease can be fatal.[4][5][6][7]The first CDC recognized death from Lyme disease was Amanda Schmidt, age 11.[8]

Complications

Stage 3, or late disseminated, Lyme disease can cause long-term joint inflammation (Lyme arthritis) and heart rhythm problems. Brain and nervous system problems are also possible, and may include:

  • Decreased concentration
  • Memory disorders
  • Nerve damage
  • Numbness
  • Pain
  • Paralysis of the face muscles
  • Sleep disorders
  • Vision problems

References

  1. Krause PJ, Foley DT, Burke GS, Christianson D, Closter L, Spielman A (2006). "Reinfection and relapse in early Lyme disease". Am. J. Trop. Med. Hyg. 75 (6): 1090–4. PMID 17172372.
  2. Cairns V, Godwin J (2005). "Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms". Int J Epidemiol. 34 (6): 1340–5. PMID 16040645.
  3. Klempner MS, Hu LT, Evans J; et al. (2001). "Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease". N Engl J Med. 345 (2): 85–92. PMID 11450676.
  4. Kirsch M, Ruben FL, Steere AC, Duray PH, Norden CW, Winkelstein A (1988). "Fatal adult respiratory distress syndrome in a patient with Lyme disease". JAMA. 259 (18): 2737–9. PMID 3357244.
  5. Oksi J, Kalimo H, Marttila RJ; et al. (1996). "Inflammatory brain changes in Lyme borreliosis. A report on three patients and review of literature". Brain. 119 (Pt 6): 2143–54. PMID 9010017.
  6. Waniek C, Prohovnik I, Kaufman MA, Dwork AJ (1995). "Rapidly progressive frontal-type dementia associated with Lyme disease". J Neuropsychiatry Clin Neurosci. 7 (3): 345–7. PMID 7580195.
  7. Cary NR, Fox B, Wright DJ, Cutler SJ, Shapiro LM, Grace AA (1990). "Fatal Lyme carditis and endodermal heterotopia of the atrioventricular node". Postgrad Med J. 66 (772): 134–6. PMID 2349186.
  8. "First Lyme Disease Death Told". Los Angeles Times. 1990-09-26.


Template:WikiDoc Sources