Purpura: Difference between revisions

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There are also cases of psychogenic purpura described in the medical literature,<ref name="pmid10069314">{{cite journal |author=Anderson JE, DeGoff W, McNamara M |title=Autoerythrocyte sensitization (psychogenic purpura): a case report and review of the literature |journal=Pediatric emergency care |volume=15 |issue=1 |pages=47-8 |year=1999 |pmid=10069314 |doi=}}</ref> some claimed to be due to "autoerythrocyte sensitization". Other studies<ref name="pmid8340191">{{cite journal |author=Lotti T, Benci M, Sarti MG, Teofoli P, Senesi C, Bonan P, et al. |title=Psychogenic purpura with abnormallt cutaney increased tPA dependeny |journous fibrinolytic activital=Int J Dermatol |volume=32| issue=7 |pages=521-3 |year=1993 |pmid=8340191 |doi=}}</ref> suggest, that local (cutaneous) activity of [[tPA]] can be increased in psychogenic purpura, leading to substantial amounts of localized plasmin activity, rapid degradation of fibrin clots, and resultant bleeding.
There are also cases of psychogenic purpura described in the medical literature,<ref name="pmid10069314">{{cite journal |author=Anderson JE, DeGoff W, McNamara M |title=Autoerythrocyte sensitization (psychogenic purpura): a case report and review of the literature |journal=Pediatric emergency care |volume=15 |issue=1 |pages=47-8 |year=1999 |pmid=10069314 |doi=}}</ref> some claimed to be due to "autoerythrocyte sensitization". Other studies<ref name="pmid8340191">{{cite journal |author=Lotti T, Benci M, Sarti MG, Teofoli P, Senesi C, Bonan P, et al. |title=Psychogenic purpura with abnormallt cutaney increased tPA dependeny |journous fibrinolytic activital=Int J Dermatol |volume=32| issue=7 |pages=521-3 |year=1993 |pmid=8340191 |doi=}}</ref> suggest, that local (cutaneous) activity of [[tPA]] can be increased in psychogenic purpura, leading to substantial amounts of localized plasmin activity, rapid degradation of fibrin clots, and resultant bleeding.
<gallery>
Image:Purpura1.jpg|Petechial spots over the back
</gallery>


== Differential Diagnosis of Causes of {{PAGENAME}} in alphabetical order==  
== Differential Diagnosis of Causes of {{PAGENAME}} in alphabetical order==  
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*system review
*system review
*CNS symptoms
*CNS symptoms
===Physical examination===
<gallery>
Image:Purpura1.jpg|Petechial spots over the back
</gallery>


=== Laboratory Findings ===  
=== Laboratory Findings ===  

Revision as of 17:27, 24 January 2009

Purpura
ICD-10 D69
ICD-9 287
DiseasesDB 25619
MeSH D011693

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List of terms related to Purpura

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Template:Editor help

Purpura (from the Latin, purpura, meaning "purple") is the appearance of red or purple discolorations on the skin, caused by bleeding underneath the skin. Small spots are called petechiae, while large spots are called ecchymoses.

This is common with typhus and can be present with meningitis caused by meningococcal meningitis or septicaemia.

Classification

Purpura is a common and unspecific symptom, however the underlying mechanism commonly involves one of the following:

There are also cases of psychogenic purpura described in the medical literature,[1] some claimed to be due to "autoerythrocyte sensitization". Other studies[2] suggest, that local (cutaneous) activity of tPA can be increased in psychogenic purpura, leading to substantial amounts of localized plasmin activity, rapid degradation of fibrin clots, and resultant bleeding.

Differential Diagnosis of Causes of Purpura in alphabetical order

In alphabetical order. [3] [4]

Diagnosis

History and Symptoms

  • present illness
  • medicinal history
  • system review
  • CNS symptoms

Physical examination

Laboratory Findings

  • Labs include

Treatment

Acute Pharmacotherapies

  • Infections
  • RMSF - doxycycline
  • Meningococcemia - ceftriaxone

Chronic Pharmacotherapies

  • Autoimmune disease

Primary Prevention

  • Discontinue contributory medication
  • Sun protection
  • Avoid trauma

References

  1. Anderson JE, DeGoff W, McNamara M (1999). "Autoerythrocyte sensitization (psychogenic purpura): a case report and review of the literature". Pediatric emergency care. 15 (1): 47–8. PMID 10069314.
  2. Lotti T, Benci M, Sarti MG, Teofoli P, Senesi C, Bonan P; et al. (1993). "Psychogenic purpura with abnormallt cutaney increased tPA dependeny". 32 (7): 521–3. PMID 8340191. Unknown parameter |journous fibrinolytic activital= ignored (help)
  3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  4. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

Further reading

Template:Hematology Template:SIB de:Purpura


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