Beta-thalassemia history and symptoms: Difference between revisions
| Line 6: | Line 6: | ||
==History and Symptoms== | ==History and Symptoms== | ||
Patients with beta-thalassemia major appear between the ages of 6 and 24 months, when fetal (HbF) hemoglobin synthesis changes to adult (HbA) hemoglobin production (HbA). | |||
Major variant patients present in early infancy with: | Major variant patients present in early infancy with: | ||
Revision as of 20:22, 16 August 2023
|
Beta-thalassemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Beta-thalassemia history and symptoms On the Web |
|
American Roentgen Ray Society Images of Beta-thalassemia history and symptoms |
|
Risk calculators and risk factors for Beta-thalassemia history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
History and Symptoms
Patients with beta-thalassemia major appear between the ages of 6 and 24 months, when fetal (HbF) hemoglobin synthesis changes to adult (HbA) hemoglobin production (HbA).
Major variant patients present in early infancy with:
- Severe anemia
- Failure to thrive
- Pallor
- Jaundice
- Fatigue
- Growth retardation
After treatment initiation, they would have symptoms of iron overload due to multiple transfusions which may cause:
- Fatigue and weakness
- Arthritis
- Abdominal pain
- Bronzed or grayish skin
- Loss of libido
- Hormonal imbalances
- Cognitive problems
Intermedia variant patients might experience moderate anemia, splenomegaly, bone changes, and intermittent need for blood transfusions at different ages[1][2][3]
Usually, beta-thalassemia minor is found by chance during a regular full blood count. Patients may have minimal anemic symptoms without obvious physical test results.
References
- ↑ Motta I, Bou-Fakhredin R, Taher AT, Cappellini MD (July 2020). "Beta Thalassemia: New Therapeutic Options Beyond Transfusion and Iron Chelation". Drugs. 80 (11): 1053–1063. doi:10.1007/s40265-020-01341-9. PMID 32557398 Check
|pmid=value (help). - ↑ Ali S, Mumtaz S, Shakir HA, Khan M, Tahir HM, Mumtaz S, Mughal TA, Hassan A, Kazmi S, Sadia, Irfan M, Khan MA (December 2021). "Current status of beta-thalassemia and its treatment strategies". Mol Genet Genomic Med. 9 (12): e1788. doi:10.1002/mgg3.1788. PMC 8683628 Check
|pmc=value (help). PMID 34738740 Check|pmid=value (help). Vancouver style error: initials (help) - ↑ Khandros E, Kwiatkowski JL (June 2019). "Beta Thalassemia: Monitoring and New Treatment Approaches". Hematol Oncol Clin North Am. 33 (3): 339–353. doi:10.1016/j.hoc.2019.01.003. PMID 31030806.