Beta-thalassemia historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]

Overview

The Thalassemia term was invented by a hematologist, Dr. Thomas Cooley, in 1925. It has a Greek origin and consists of Thalassa and Emia which mean sea and blood, respectively. The diagnostic certainty was ultimately established with hemoglobin electrophoresis in the 20th century.

Historical Perspective

The Thalassemia term was coined by Dr. Thomas Cooley (1871-1945), an American hematologist, in 1925, when he first described the disease in the Mediterranean Sea descent. Thalassemia is a Greek word derived from Thalassa meaning sea and Emia meaning blood [1]. The pattern of the disease was also observed and recorded in the Middle East and Southeast Asia frequently. Later, Dr. James V. Neel distinguished thalassemia from sickle cell anemia. VALENTINE, W. N., and J. V. NEEL, Hematologic and genetic study of the transmission of thalassemia. Arch. Intern. Med. 1944, 74: 185-196. The diagnostic certainty was ultimately established with hemoglobin electrophoresis in the 20th century.[2]

References

  1. Siddiqui S, Steensma DP, Kyle RA (November 2017). "Thalassemia and Thomas Benton Cooley". Mayo Clin Proc. 92 (11): e161–e162. doi:10.1016/j.mayocp.2017.06.024. PMID 29101943.
  2. Louderback AL, Shanbrom E (November 1967). "Hemoglobin electrophoresis". JAMA. 202 (8): 718–9. PMID 6072515.


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