Wild-type (senile) amyloidosis natural history, complications and prognosis: Difference between revisions
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* In [[amyloidosis]], insoluble fibrils of [[amyloid]] are deposited in the [[Organ (anatomy)|organs]], causing organ dysfunction and eventually death.<ref name="pmid23227278">{{cite journal |vauthors=Baker KR, Rice L |title=The amyloidoses: clinical features, diagnosis and treatment |journal=Methodist Debakey Cardiovasc J |volume=8 |issue=3 |pages=3–7 |date=2012 |pmid=23227278 |pmc=3487569 |doi= |url=}}</ref> | * In [[amyloidosis]], insoluble fibrils of [[amyloid]] are deposited in the [[Organ (anatomy)|organs]], causing organ dysfunction and eventually death.<ref name="pmid23227278">{{cite journal |vauthors=Baker KR, Rice L |title=The amyloidoses: clinical features, diagnosis and treatment |journal=Methodist Debakey Cardiovasc J |volume=8 |issue=3 |pages=3–7 |date=2012 |pmid=23227278 |pmc=3487569 |doi= |url=}}</ref> | ||
*Wild-type (senile) amyloidosis, as the name suggests, is a disease of the elderly. | *Wild-type (senile) amyloidosis, as the name suggests, is a disease of the elderly. | ||
*The clinical | *The clinical picture of the disease corresponds to the type of organ or organ system involved. | ||
*It most commonly affects the heart and hence, clinical features pertaining to cardiac pathologies, dominate the clinical course of the disease. | *It most commonly affects the heart and hence, clinical features pertaining to cardiac pathologies, dominate the clinical course of the disease. | ||
*The deposition of transthyretin (TTR) in the heart causes it to start functionally failing. | *The deposition of transthyretin (TTR) in the heart causes it to start functionally failing. | ||
*The constellation of signs and symptoms | *The constellation of signs and symptoms of a TTR affected heart can mimic heart failure due to old age and can thus mask wild-type (senile) amyloidosis. | ||
* | |||
===Complications=== | ===Complications=== |
Revision as of 18:42, 17 December 2019
Wild-type (senile) amyloidosis Microchapters |
Differentiating Wild-type (senile) amyloidosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Natural History, Complications, and Prognosis
Natural History
- In amyloidosis, insoluble fibrils of amyloid are deposited in the organs, causing organ dysfunction and eventually death.[1]
- Wild-type (senile) amyloidosis, as the name suggests, is a disease of the elderly.
- The clinical picture of the disease corresponds to the type of organ or organ system involved.
- It most commonly affects the heart and hence, clinical features pertaining to cardiac pathologies, dominate the clinical course of the disease.
- The deposition of transthyretin (TTR) in the heart causes it to start functionally failing.
- The constellation of signs and symptoms of a TTR affected heart can mimic heart failure due to old age and can thus mask wild-type (senile) amyloidosis.