Neurofibroma laboratory findings: Difference between revisions
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|+Immunohistochemical differences between Neurofibroma and Schwannoma | |+Immunohistochemical differences between Neurofibroma and Schwannoma | ||
!Immunohistochemical stain | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Immunohistochemical stain | ||
!Neurofibroma | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Neurofibroma | ||
!Schwannoma | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Schwannoma | ||
|- | |- | ||
|'''S-100 and Sox10''' | |style="background:#DCDCDC;" align="center" + |'''S-100 and Sox10''' | ||
|Moderate positivity | |Moderate positivity | ||
|Strong, diffuse positivity | |Strong, diffuse positivity | ||
|- | |- | ||
|'''CD34''' | |style="background:#DCDCDC;" align="center" + |'''CD34''' | ||
|Moderate | |Moderate | ||
|Scattered cells in Antoni B areas | |Scattered cells in Antoni B areas | ||
|- | |- | ||
|'''Neurofilament (and Bielshowsky)''' | |style="background:#DCDCDC;" align="center" + |'''Neurofilament (and Bielshowsky)''' | ||
|Stains entrapped axons within lesion | |Stains entrapped axons within lesion | ||
|Stains peripherally located axons of parent nerve | |Stains peripherally located axons of parent nerve | ||
|- | |- | ||
|'''Factor XIIIa''' | |style="background:#DCDCDC;" align="center" + |'''Factor XIIIa''' | ||
|Moderate | |Moderate | ||
|Negative to focal | |Negative to focal | ||
|- | |- | ||
|'''Calretinin''' | |style="background:#DCDCDC;" align="center" + |'''Calretinin''' | ||
|Negative to focal | |Negative to focal | ||
|Moderate | |Moderate | ||
|- | |- | ||
|'''GFAP''' | |style="background:#DCDCDC;" align="center" + |'''GFAP''' | ||
|Variable, weak | |Variable, weak | ||
|Variable, moderate | |Variable, moderate |
Revision as of 16:43, 29 March 2019
Neurofibroma Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Neurofibroma laboratory findings On the Web |
American Roentgen Ray Society Images of Neurofibroma laboratory findings |
Risk calculators and risk factors for Neurofibroma laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
Immunohistochemistry of neurofibroma shows positivity for S100, CD34, and factor XIIIa and negativity for EMA (except in plexiform neurofibromas).
Laboratory Findings
Immunohistochemistry of neurofibroma is as follows:
- Positive for:
- Negative for:
- EMA (except in plexiform neurofibromas)
- Keratin
- Smooth muscle actin
- Desmin
- Calponin
- Caldesmon
- p53
Immunohistochemical stain | Neurofibroma | Schwannoma |
---|---|---|
S-100 and Sox10 | Moderate positivity | Strong, diffuse positivity |
CD34 | Moderate | Scattered cells in Antoni B areas |
Neurofilament (and Bielshowsky) | Stains entrapped axons within lesion | Stains peripherally located axons of parent nerve |
Factor XIIIa | Moderate | Negative to focal |
Calretinin | Negative to focal | Moderate |
GFAP | Variable, weak | Variable, moderate |