Adenocarcinoma: Difference between revisions

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{{SI}}
{{SI}}


{{CMG}}
==Overview==
'''Adenocarcinoma''' is a form of [[carcinoma]] that originates in [[glandular]] tissue. To be classified as adenocarcinoma, the cells do not necessarily need to be part of a [[gland]], as long as they have secretory properties.  This form of carcinoma can occur in some higher mammals, including humans.<ref>Fauquier, D.A.,  Gulland, F.M.D.,(Marine Mammal Center), Haulena, M., Spraker, T., ‘’Biliary adenocarcinoma in a stranded Northern elephant seal (‘’Mirounga angustirortsis’‘)’‘, Journal of Wildlife Diseases 39(3):723-726 (2003)</ref> The term adenocarcinoma is derived from 'adeno' meaning 'pertaining to a gland' and '[[carcinoma]]', which describes a cancer that has developed in the [[epithelial]] cells. It can first present as an [[adenoma]] (a glandular tumor that is [[benign]]).
==Pathophysiology==
Examples of tissues where adenocarcinomas may arise:
* [[Breast cancer]]
* [[Colon cancer]]
* [[Lung cancer]]
* [[Prostate cancer]]
* [[Stomach cancer]]
* [[Pancreatic cancer]] (99% of pancreatic cancers are ductal adenocarcinomas [http://www.emedicine.com/radio/topic516.htm])
* [[Cervical cancer]]
* [[Vaginal cancer]]
===Gross Pathology===
<gallery>
Image:gastcarc_enface.jpg|This cancer presented in a 40-year-old woman complaining of abdominal pain. Endoscopically it was a "very suspicious" ulcer. Biopsy showed diffusely infiltrating signet ring cell adenocarcinoma. These are gross photos of the subtotal gastrectomy specimen. The photo above is a seen face view of the ulcer. The pyloric margin is to the left. The ulcer is on the lesser curvature.
Image:Gastcarc xsec.jpg|This is a longitudinal section cut in the plane of the lesser curvature. The pylorus is to the left. Note several prominent nodes of the lesser omentum; these contained metastatic cancer.
</gallery>
==Physical Examination==
===Adenocarcinoma-In The Submandibular Salivary Glands===
<gallery widths="200px">
180.jpg | Adenocarcinoma-In The Submandibular Salivary Glands <br> [http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=20 <font size="-2">''Adapted from Dermatology Atlas''</font>]
181.jpg | Adenocarcinoma-In The Submandibular Salivary Glands <br> [http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=20 <font size="-2">''Adapted from Dermatology Atlas''</font>]
182.jpg | Adenocarcinoma-In The Submandibular Salivary Glands <br> [http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=20 <font size="-2">''Adapted from Dermatology Atlas''</font>]
</gallery>
==Differential Diagnosis==
{| class="wikitable"
{| class="wikitable"
|+
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
!
! rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Diseases
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Risk factors/Epidemiology
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | History
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Clinical Findings
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Gross Pathology
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Histopathology
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Immunohistochemistry
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Lab Findings
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Imaging
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Metastatic Potential
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Gold Standard
!
! colspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" | Additional Findings
|-
|-
!
!
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|}
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{{CMG}}
==Overview==
'''Adenocarcinoma''' is a form of [[carcinoma]] that originates in [[glandular]] tissue. To be classified as adenocarcinoma, the cells do not necessarily need to be part of a [[gland]], as long as they have secretory properties.  This form of carcinoma can occur in some higher mammals, including humans.<ref>Fauquier, D.A.,  Gulland, F.M.D.,(Marine Mammal Center), Haulena, M., Spraker, T., ‘’Biliary adenocarcinoma in a stranded Northern elephant seal (‘’Mirounga angustirortsis’‘)’‘, Journal of Wildlife Diseases 39(3):723-726 (2003)</ref> The term adenocarcinoma is derived from 'adeno' meaning 'pertaining to a gland' and '[[carcinoma]]', which describes a cancer that has developed in the [[epithelial]] cells. It can first present as an [[adenoma]] (a glandular tumor that is [[benign]]).
==Pathophysiology==
Examples of tissues where adenocarcinomas may arise:
* [[Breast cancer]]
* [[Colon cancer]]
* [[Lung cancer]]
* [[Prostate cancer]]
* [[Stomach cancer]]
* [[Pancreatic cancer]] (99% of pancreatic cancers are ductal adenocarcinomas [http://www.emedicine.com/radio/topic516.htm])
* [[Cervical cancer]]
* [[Vaginal cancer]]
===Gross Pathology===
<gallery>
Image:gastcarc_enface.jpg|This cancer presented in a 40-year-old woman complaining of abdominal pain. Endoscopically it was a "very suspicious" ulcer. Biopsy showed diffusely infiltrating signet ring cell adenocarcinoma. These are gross photos of the subtotal gastrectomy specimen. The photo above is a seen face view of the ulcer. The pyloric margin is to the left. The ulcer is on the lesser curvature.
Image:Gastcarc xsec.jpg|This is a longitudinal section cut in the plane of the lesser curvature. The pylorus is to the left. Note several prominent nodes of the lesser omentum; these contained metastatic cancer.
</gallery>
==Physical Examination==
===Adenocarcinoma-In The Submandibular Salivary Glands===
<gallery widths="200px">
180.jpg | Adenocarcinoma-In The Submandibular Salivary Glands <br> [http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=20 <font size="-2">''Adapted from Dermatology Atlas''</font>]
181.jpg | Adenocarcinoma-In The Submandibular Salivary Glands <br> [http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=20 <font size="-2">''Adapted from Dermatology Atlas''</font>]
182.jpg | Adenocarcinoma-In The Submandibular Salivary Glands <br> [http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=20 <font size="-2">''Adapted from Dermatology Atlas''</font>]
</gallery>
==Differential Diagnosis==


==References==
==References==

Revision as of 14:04, 7 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Adenocarcinoma is a form of carcinoma that originates in glandular tissue. To be classified as adenocarcinoma, the cells do not necessarily need to be part of a gland, as long as they have secretory properties. This form of carcinoma can occur in some higher mammals, including humans.[1] The term adenocarcinoma is derived from 'adeno' meaning 'pertaining to a gland' and 'carcinoma', which describes a cancer that has developed in the epithelial cells. It can first present as an adenoma (a glandular tumor that is benign).

Pathophysiology

Examples of tissues where adenocarcinomas may arise:

Gross Pathology

Physical Examination

Adenocarcinoma-In The Submandibular Salivary Glands


Differential Diagnosis

Diseases Risk factors/Epidemiology History Clinical Findings Gross Pathology Histopathology Immunohistochemistry Lab Findings Imaging Metastatic Potential Gold Standard Additional Findings

References

  1. Fauquier, D.A., Gulland, F.M.D.,(Marine Mammal Center), Haulena, M., Spraker, T., ‘’Biliary adenocarcinoma in a stranded Northern elephant seal (‘’Mirounga angustirortsis’‘)’‘, Journal of Wildlife Diseases 39(3):723-726 (2003)

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