Appendix cancer epidemiology and demographics: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
*Epidemiology of appendix cancer should be discussed with respect to the major histological characteristics of tumors. | *Epidemiology of appendix cancer should be discussed with respect to the major histological characteristics of tumors. | ||
*Prevalence, risk factors, age distribution as well as prognosis are different in two major types of apendiceal cancers. | *Prevalence, risk factors, age distribution as well as prognosis are different in two major types of apendiceal cancers.<ref name="WHO"> Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019</ref> | ||
* According to the [https://seer.cancer.gov/statistics/ SEER database], adenocarcinoma accounted for 58% of appendiceal tumors. | * According to the [https://seer.cancer.gov/statistics/ SEER database], adenocarcinoma accounted for 58% of appendiceal tumors. <ref name="pmid8000994">{{cite journal| author=Thomas RM, Sobin LH| title=Gastrointestinal cancer. | journal=Cancer | year= 1995 | volume= 75 | issue= 1 Suppl | pages= 154-70 | pmid=8000994 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8000994 }} </ref> | ||
* Carcinoid tumors comprise 50-77% of appendiceal malignancies. | * Carcinoid tumors comprise 50-77% of appendiceal malignancies.<ref name="pmid464679">{{cite journal| author=Syracuse DC, Perzin KH, Price JB, Wiedel PD, Mesa-Tejada R| title=Carcinoid tumors of the appendix. Mesoappendiceal extension and nodal metastases. | journal=Ann Surg | year= 1979 | volume= 190 | issue= 1 | pages= 58-63 | pmid=464679 | doi= | pmc=1344458 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=464679 }} </ref> | ||
===Incidence=== | ===Incidence=== | ||
*The incidence of carcinoid tumor of appendix is approximately 0.075 per 100,000 individuals worldwide.<ref name="pmid9024720">{{cite journal| author=Modlin IM, Sandor A| title=An analysis of 8305 cases of carcinoid tumors. | journal=Cancer | year= 1997 | volume= 79 | issue= 4 | pages= 813-29 | pmid=9024720 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9024720 }} </ref> | *The incidence of carcinoid tumor of appendix is approximately 0.075 per 100,000 individuals worldwide.<ref name="pmid9024720">{{cite journal| author=Modlin IM, Sandor A| title=An analysis of 8305 cases of carcinoid tumors. | journal=Cancer | year= 1997 | volume= 79 | issue= 4 | pages= 813-29 | pmid=9024720 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9024720 }} </ref> | ||
Revision as of 14:52, 16 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Soroush Seifirad, M.D.[2]
Overview
Epidemiology and Demographics
- Epidemiology of appendix cancer should be discussed with respect to the major histological characteristics of tumors.
- Prevalence, risk factors, age distribution as well as prognosis are different in two major types of apendiceal cancers.[1]
- According to the SEER database, adenocarcinoma accounted for 58% of appendiceal tumors. [2]
- Carcinoid tumors comprise 50-77% of appendiceal malignancies.[3]
Incidence
- The incidence of carcinoid tumor of appendix is approximately 0.075 per 100,000 individuals worldwide.[4]
- The incidence of adenocarcinoma of the appendix is approximately 0.2 per 100,000 individuals worldwide.[5]
Prevalence
- Appendiceal neoplasms account for approximately 0.4% of gastrointestinal tumors.
- The estimated prevalence of appendix cancer is approximately 0.12 cases per 100,000 individuals in the United States.[6]
- The estimated prevalence of adenocarcinoma of the appendix is 0.2 cases per 100,000 individuals worldwide;[6] on the other hand,?????????
Case-fatality rate/Mortality rate
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- In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
- The case-fatality rate/mortality rate of [disease name] is approximately [number range].
Age
- The incidence of apendix cancer increases with age; meanwhile, patients with carcinoid tumors are generally younger than their adenocarcinoma counterparts.
- The median age at diagnosis is 65 years for adenocarcinoma, compared to t 32-43 years (range, 6 to 80 years) for carcinoid tumors.
- The patients with Tubular carcinoids are significantly younger than the patients with goblet cell carcinoids.[7]
Race
- There is no racial predilection to appendiceal cancers.
Gender
- Generally appendiceal cancers affects men and women equally.
- While in adenocarcinoma there is a male dominant pattern of prevalence, females are more commonly affected by appendiceal carcinoids than men; This might be because of high incidental appendicectomies in women. Nevertheless, in the SEER database, the male to female ratio is approximately 1 to 1.
References ???????????????
- ↑ Chapter 5: Tumours of the Appendix - IARC. https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/bb2-chap5.pdf Accessed on January 15, 2019
- ↑ Thomas RM, Sobin LH (1995). "Gastrointestinal cancer". Cancer. 75 (1 Suppl): 154–70. PMID 8000994.
- ↑ Syracuse DC, Perzin KH, Price JB, Wiedel PD, Mesa-Tejada R (1979). "Carcinoid tumors of the appendix. Mesoappendiceal extension and nodal metastases". Ann Surg. 190 (1): 58–63. PMC 1344458. PMID 464679.
- ↑ Modlin IM, Sandor A (1997). "An analysis of 8305 cases of carcinoid tumors". Cancer. 79 (4): 813–29. PMID 9024720.
- ↑ Deans GT, Spence RA (1995). "Neoplastic lesions of the appendix". Br J Surg. 82 (3): 299–306. PMID 7795991.
- ↑ 6.0 6.1 Turaga KK, Pappas SG, Gamblin T (2012). "Importance of histologic subtype in the staging of appendiceal tumors". Ann. Surg. Oncol. 19 (5): 1379–85. doi:10.1245/s10434-012-2238-1. PMID 22302267.
- ↑ Burke AP, Sobin LH, Federspiel BH, Shekitka KM, Helwig EB (1990). "Goblet cell carcinoids and related tumors of the vermiform appendix". Am J Clin Pathol. 94 (1): 27–35. PMID 2163192.