Hepatocellular adenoma risk factors: Difference between revisions

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{{Hepatocellular adenoma}}
{{Hepatocellular adenoma}}
{{CMG}};{{AE}} {{NM}}
{{CMG}};{{AE}} {{ZAS}}
==Overview==
==Overview==
The most potent risk factor in the development of hepatocellular adenoma is use of oral contraceptive pills.<ref name=risk>How do oral contraceptives affect liver cancer risk. National Cancer Institute 2015. http://www.cancer.gov/about-cancer/causes-prevention/risk/hormones/oral-contraceptives-fact-sheet</ref>
The most important risk factor in the development of haptocellular adenoma is use of oral contraceptive medications. Other risk factors include; glycogen storage diseases, familial adenomatous polyposis, klinefelters syndrome, metabolic syndrome, obesity, long term use of anabolic androgenic steroids, vascular disorders such as portal vein agenesis, budd chiari syndrome and hereditary hemorrhagic telangiectasia.
 
==Hepatocellular adenoma risk factors==
==Hepatocellular adenoma risk factors==
* The most potent risk factor in the development of hepatocellular adenoma is use of oral contraceptive pills.<ref name=risk>How do oral contraceptives affect liver cancer risk. National Cancer Institute 2015. http://www.cancer.gov/about-cancer/causes-prevention/risk/hormones/oral-contraceptives-fact-sheet</ref>
* The most potent risk factor in the development of hepatocellular adenoma is use of oral contraceptive medications.
:*[[Drospirenone and Ethinyl estradiol]]
:*[[Drospirenone and Ethinyl estradiol]]
:*[[Norethindrone acetate and Ethinyl estradiol]]
:*[[Norethindrone acetate and Ethinyl estradiol]]
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:* Types I, III and IV [[glycogen storage disease]]
:* Types I, III and IV [[glycogen storage disease]]
:* [[Familial adenomatous polyposis]]
:* [[Familial adenomatous polyposis]]
==Risk factors for malignant transformation==
==Risk factors for malignant transformation==
The risk factor for malignant transformation of hepatic adenoma to hepatocellular carcinoma is:<ref name="pmid25786843">{{cite journal| author=Aamann L, Schultz N, Fallentin E, Hamilton-Dutoit S, Vogel I, Grønbæk H| title=[Hepatocellular adenoma - new classification and recommendations]. | journal=Ugeskr Laeger | year= 2015 | volume= 177 | issue= 12 | pages=  | pmid=25786843 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25786843  }} </ref>
The risk factor for malignant transformation of hepatic adenoma to hepatocellular carcinoma is:<ref name="pmid25786843">{{cite journal| author=Aamann L, Schultz N, Fallentin E, Hamilton-Dutoit S, Vogel I, Grønbæk H| title=[Hepatocellular adenoma - new classification and recommendations]. | journal=Ugeskr Laeger | year= 2015 | volume= 177 | issue= 12 | pages=  | pmid=25786843 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25786843  }} </ref>

Revision as of 15:37, 31 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Overview

The most important risk factor in the development of haptocellular adenoma is use of oral contraceptive medications. Other risk factors include; glycogen storage diseases, familial adenomatous polyposis, klinefelters syndrome, metabolic syndrome, obesity, long term use of anabolic androgenic steroids, vascular disorders such as portal vein agenesis, budd chiari syndrome and hereditary hemorrhagic telangiectasia.

Hepatocellular adenoma risk factors

  • The most potent risk factor in the development of hepatocellular adenoma is use of oral contraceptive medications.
  • Hormonal dose
  • Duration of medication
  • Other risk factors include:[1]

Risk factors for malignant transformation

The risk factor for malignant transformation of hepatic adenoma to hepatocellular carcinoma is:[2]

  • Gender (men)
  • Size (> 8 cm)
  • Subtype (beta-catenin-activated HCA)

References

  1. 1.0 1.1 Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
  2. Aamann L, Schultz N, Fallentin E, Hamilton-Dutoit S, Vogel I, Grønbæk H (2015). "[Hepatocellular adenoma - new classification and recommendations]". Ugeskr Laeger. 177 (12). PMID 25786843.


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