Hepatocellular adenoma classification: Difference between revisions

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Hepatocellular adenoma may be classified according to the rate of occurence into four subtypes: Inflammatory hepatocellular adenoma, ''HNF1-alpha'' mutated hepatocellular adenoma, ''[[beta-catenin]]'' mutated hepatocellular adenoma, and unclassified hepatocellular adenoma.<ref name=hepatocellularadenoma>Pathology of hepatocellular adenoma. Dr Matt A. Morgan◉ and Dr Koshy Jacob et al. Radiopaedia (2015). http://radiopaedia.org/articles/hepatic-adenoma. Accessed on October 16, 2015</ref>
Hepatocellular adenoma may be classified according to the rate of occurence into four subtypes: Inflammatory hepatocellular adenoma, ''HNF1-alpha'' mutated hepatocellular adenoma, ''[[beta-catenin]]'' mutated hepatocellular adenoma, and unclassified hepatocellular adenoma.<ref name=hepatocellularadenoma>Pathology of hepatocellular adenoma. Dr Matt A. Morgan◉ and Dr Koshy Jacob et al. Radiopaedia (2015). http://radiopaedia.org/articles/hepatic-adenoma. Accessed on October 16, 2015</ref>
==Classification==
==Classification==
Hepatocellular adenoma may be classified into four subtypes based on the rate of occurence.<ref name=hepatocellularadenoma>Pathology of hepatocellular adenoma. Dr Matt A. Morgan◉ and Dr Koshy Jacob et al. Radiopaedia (2015). http://radiopaedia.org/articles/hepatic-adenoma. Accessed on October 16, 2015</ref>
* In 2007, Bioulac-sage and associates from bordeaux classified the hepatocellular adenomas based on molecular patterns called phenotypic-genotypic classification. They classified heaptocellular adenomas into 04 main groups.
The table below lists subtypes of hepatocellular adenoma:
{| style="border: 100px; font-size: 90%; margin: 3px; width: 400px"
|valign=top|
|+
! style="background: #4479BA; width: 250px; color: #FFFFFF;"|'''Subtype'''


! style="background: #4479BA; width: 600px; color: #FFFFFF;"|'''Description'''


|-
{{familytree/start}}
 
{{familytree | | | | | | | | | | A01 | | | | | | | | | |A01=Hepatocellular Adenoma }}
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''[[Inflammatory hepatocellular adenoma]]'''|| style="padding: 5px 5px; background: #F5F5F5;"|
{{familytree | | | |,|-|-|-|v|-|-|^|-|-|v|-|-|-|.| | | | }}
* Most common<br>
{{familytree | | | |!| | | |!| | | | | |!| | | |!| | | | }}
* Highest rate of bleeding
{{familytree | | | B01 | | B02 | | | | B03 | | B04 | | |B01=HNF-1 alpha inactivated adenoma|B02=Beta catenin activated adenoma|B03=Inflammatory hepatic adenoma|B04=Unclassified type adenoma }}
 
{{familytree | | | | | | | | | | | | | | | | | | | | | | }}
|-
{{familytree/end}}
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''''HNF1-alpha'' mutated hepatocellular adenoma'''|| style="padding: 5px 5px; background: #F5F5F5;"|
* Second most common
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''''Beta-catenin'' mutated hepatocellular adenoma'''|| style="padding: 5px 5px; background: #F5F5F5;"|
* Least common
* Associated with:
:*Men on anabolic steroids
:*[[Glycogen storage disease]]
:*[[Familial adenomatous polyposis]]
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Unclassified hepatocellular adenoma'''|| style="padding: 5px 5px; background: #F5F5F5;" |
 
|-
 
|}


==References==
==References==

Revision as of 20:36, 11 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

Hepatocellular adenoma may be classified according to the rate of occurence into four subtypes: Inflammatory hepatocellular adenoma, HNF1-alpha mutated hepatocellular adenoma, beta-catenin mutated hepatocellular adenoma, and unclassified hepatocellular adenoma.[1]

Classification

  • In 2007, Bioulac-sage and associates from bordeaux classified the hepatocellular adenomas based on molecular patterns called phenotypic-genotypic classification. They classified heaptocellular adenomas into 04 main groups.


 
 
 
 
 
 
 
 
 
Hepatocellular Adenoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
HNF-1 alpha inactivated adenoma
 
Beta catenin activated adenoma
 
 
 
Inflammatory hepatic adenoma
 
Unclassified type adenoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

References

  1. Pathology of hepatocellular adenoma. Dr Matt A. Morgan◉ and Dr Koshy Jacob et al. Radiopaedia (2015). http://radiopaedia.org/articles/hepatic-adenoma. Accessed on October 16, 2015


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