Hemolytic-uremic syndrome laboratory findings: Difference between revisions
No edit summary |
|||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{HUS}} | {{HUS}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{AHS}} | ||
==Overview== | ==Overview== | ||
| Line 24: | Line 24: | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Following Lab findings are seen in HUS: | Following Lab findings are seen in HUS<ref name="pmid26265890">{{cite journal| author=Canpolat N| title=Hemolytic uremic syndrome. | journal=Turk Pediatri Ars | year= 2015 | volume= 50 | issue= 2 | pages= 73-82 | pmid=26265890 | doi=10.5152/tpa.2015.2297 | pmc=4523989 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26265890 }} </ref>: | ||
* '''Microangiopathic Hemolytic Anemia''' with features as follows: | * '''Microangiopathic Hemolytic Anemia''' with features as follows: | ||
** Low Hemoglobin level Often < 10g/dl | ** Low Hemoglobin level Often < 10g/dl | ||
| Line 31: | Line 31: | ||
** Low Haptoglobin level | ** Low Haptoglobin level | ||
** Negative Coombs test | ** Negative Coombs test | ||
** Peripheral Blood smear shows fragmented RBC's (Schistiocytes, Helmet and Burr | ** Peripheral Blood smear shows fragmented RBC's (Schistiocytes, Helmet, and Burr cells) | ||
* '''Thrombocytopenia''' | * '''Thrombocytopenia''' | ||
** Below 150,000 although typically less than 60,000. In spite of low platelet count, active bleeding is rarely seen | ** Below 150,000 although typically less than 60,000. In spite of low platelet count, active bleeding is rarely seen | ||
| Line 37: | Line 37: | ||
** High BUN | ** High BUN | ||
** High Creatinine | ** High Creatinine | ||
** Electrolyte abnormalities may include Hyponatremia, Hyperkalemia, Hyperphosphatemia, Hypocalcemia and acidosis (resulting from diarrhea, dehydration and renal failure) | ** Electrolyte abnormalities may include Hyponatremia, Hyperkalemia, Hyperphosphatemia, Hypocalcemia, and acidosis (resulting from diarrhea, dehydration and renal failure) | ||
** Increased Bilirubin and aminotransferases | ** Increased Bilirubin and aminotransferases | ||
** High uric acid levels | ** High uric acid levels | ||
| Line 49: | Line 49: | ||
** Stool culture on Sorbitol MacConkey's agar or Detection of Shiga toxin with serological testing | ** Stool culture on Sorbitol MacConkey's agar or Detection of Shiga toxin with serological testing | ||
* '''Genetic Testing''' | * '''Genetic Testing''' | ||
** Done if suspicion of genetic or complement mediated HUS/ recurrent HUS. However results | ** Done if suspicion of genetic or complement-mediated HUS/ recurrent HUS. However, results take weeks-month thus have no role in the acute management of disease and treatment should not be delayed while awaiting results | ||
==References== | ==References== | ||
Revision as of 19:56, 9 August 2018
|
Hemolytic-uremic syndrome Microchapters |
|
Differentiating Hemolytic-uremic syndrome from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Hemolytic-uremic syndrome laboratory findings On the Web |
|
American Roentgen Ray Society Images of Hemolytic-uremic syndrome laboratory findings |
|
Risk calculators and risk factors for Hemolytic-uremic syndrome laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anila Hussain, MD [2]
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal for patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
Following Lab findings are seen in HUS[1]:
- Microangiopathic Hemolytic Anemia with features as follows:
- Low Hemoglobin level Often < 10g/dl
- High reticulocyte count
- Increased LDH level
- Low Haptoglobin level
- Negative Coombs test
- Peripheral Blood smear shows fragmented RBC's (Schistiocytes, Helmet, and Burr cells)
- Thrombocytopenia
- Below 150,000 although typically less than 60,000. In spite of low platelet count, active bleeding is rarely seen
- Serum Chemistry abnormalities
- High BUN
- High Creatinine
- Electrolyte abnormalities may include Hyponatremia, Hyperkalemia, Hyperphosphatemia, Hypocalcemia, and acidosis (resulting from diarrhea, dehydration and renal failure)
- Increased Bilirubin and aminotransferases
- High uric acid levels
- Urinalysis-may show any of following
- Blood / Red blood cells
- Protein
- Bilirubin
- WBC
- Casts
- Stool Testing
- Stool culture on Sorbitol MacConkey's agar or Detection of Shiga toxin with serological testing
- Genetic Testing
- Done if suspicion of genetic or complement-mediated HUS/ recurrent HUS. However, results take weeks-month thus have no role in the acute management of disease and treatment should not be delayed while awaiting results
References
- ↑ Canpolat N (2015). "Hemolytic uremic syndrome". Turk Pediatri Ars. 50 (2): 73–82. doi:10.5152/tpa.2015.2297. PMC 4523989. PMID 26265890.