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==Historical Perspective== | ==Historical Perspective== | ||
* Perhaps the first case of haemolytic anaemia in the medical literature was described by the physician Claudius Galen (Dreyfus, 1942). The patient, a slave of the emperor Marcus Aurelius, hunted snakes. He was bitten by a viper and, in spite of treatment with the ‘usual drugs’, his skin ‘turned the colour of a ripe leek.’ Galen prescribed theriaca, which cured the patient. Galen explained, ‘The spleen produces colours of this type, darker even than those produced by the liver. They are difficult to explain, but easy to recognize if you have seen them often.’ | |||
* The first recognizable reports of haemolytic anaemia were undoubtedly cases of paroxysmal cold haemoglobinuria because of the dramatic presentation. Johannis Actuarius, a court physician at Constantinople during the late thirteenth century described azure, livid and black urine following chilling of certain individuals (Major, 1945). The syndrome was well known by physicians of the mid‐nineteenth century. A relationship to jaundice was recognized and the absence of RBCs from the dark urine was noted. These patients were thought to suffer from a disorder of the kidneys. | |||
==References== | ==References== | ||
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Overview
Historical Perspective
- Perhaps the first case of haemolytic anaemia in the medical literature was described by the physician Claudius Galen (Dreyfus, 1942). The patient, a slave of the emperor Marcus Aurelius, hunted snakes. He was bitten by a viper and, in spite of treatment with the ‘usual drugs’, his skin ‘turned the colour of a ripe leek.’ Galen prescribed theriaca, which cured the patient. Galen explained, ‘The spleen produces colours of this type, darker even than those produced by the liver. They are difficult to explain, but easy to recognize if you have seen them often.’
- The first recognizable reports of haemolytic anaemia were undoubtedly cases of paroxysmal cold haemoglobinuria because of the dramatic presentation. Johannis Actuarius, a court physician at Constantinople during the late thirteenth century described azure, livid and black urine following chilling of certain individuals (Major, 1945). The syndrome was well known by physicians of the mid‐nineteenth century. A relationship to jaundice was recognized and the absence of RBCs from the dark urine was noted. These patients were thought to suffer from a disorder of the kidneys.