Focal segmental glomerulosclerosis history and symptoms: Difference between revisions

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*Malaise
*Malaise
*Symptoms of chronic renal failure such as anuria, edema
*Symptoms of chronic renal failure such as anuria, edema
==Clinical Presentation==
Generally, primary (idiopathic) focal segmental glomerulosclerosis (FSGS) starts abruptly whereas secondary FSGS has a more insidious onset. The hallmark of FSGS is  appearing in approximately 70% of patients.<ref name="pmid15284302">{{cite journal| author=Chun MJ, Korbet SM, Schwartz MM, Lewis EJ| title=Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants. | journal=J Am Soc Nephrol | year= 2004 | volume= 15 | issue= 8 | pages= 2169-77 | pmid=15284302 | doi=10.1097/01.ASN.0000135051.62500.97 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15284302  }} </ref>
Common signs and symptoms associated with FSGS are shown below<ref name="pmid7702047">{{cite journal|author=Rydel JJ, Korbet SM, Borok RZ, Schwartz MM| title=Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment. | journal=Am J Kidney Dis | year= 1995 | volume= 25 | issue= 4 | pages= 534-42 | pmid=7702047 | doi= | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7702047  }} </ref><ref name="pmid15284302">{{cite journal| author=Chun MJ, Korbet SM, Schwartz MM, Lewis EJ|title=Focal segmental glomerulosclerosis in nephrotic adults: presentation, prognosis, and response to therapy of the histologic variants. | journal=J Am Soc Nephrol | year= 2004 |volume= 15 | issue= 8 | pages= 2169-77 | pmid=15284302 | doi=10.1097/01.ASN.0000135051.62500.97| pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15284302  }} </ref>:
*
*Other signs of renal insufficiency
Additionally, a must be ruled out during history-taking.
In contrast, patients with secondary FSGS is often present with non-nephrotic range proteinuria, serum albumin levels that are usually normal, and most importantly, there is no peripheral edema, even when protein excretion exceeds 3 to 4 g/day.<ref name="pmid19578004">{{cite journal| author=Fernandez-Fresnedo G, Segarra A, González E, Alexandru S, Delgado R, Ramos N et al.| title=Rituximab treatment of adult patients with steroid-resistant focal segmental glomerulosclerosis. | journal=Clin J Am Soc Nephrol | year= 2009 | volume= 4 | issue= 8 | pages= 1317-23 | pmid=19578004 | doi=10.2215/CJN.00570109 | pmc=2723972 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19578004  }} </ref>


==References==
==References==

Revision as of 13:59, 11 June 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

History and Symptoms

The hallmark of focal segmental glomerulosclerosis is nephrotic-range proteinuria.[1]  

History

Patients with focal segmental glomerulosclerosis may have a positive history of:

  • Positive family history of FSGN
  • Heroin abuse
  • Chronic viral infections such as hepatitis B
  • Medications such as bisphosphonates

Common Symptoms

Common symptoms of focal segmental glomerulosclerosis include:[2]

  • Proteinuria
  • Hematuria
  • Anasarca 
  • Headache and blurry vision which is suggestive of high blood pressure

Less Common Symptoms

Less common symptoms of [disease name] include

  • Fatigue
  • Malaise
  • Symptoms of chronic renal failure such as anuria, edema

References

  1. ↑ Rydel JJ, Korbet SM, Borok RZ, Schwartz MM (1995). "Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment". Am J Kidney Dis. 25 (4): 534–42. PMID 7702047.
  2. ↑ Choy BY, Chan TM, Lai KN (November 2006). "Recurrent glomerulonephritis after kidney transplantation". Am. J. Transplant. 6 (11): 2535–42. doi:10.1111/j.1600-6143.2006.01502.x. PMID 16939521.

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