Churg-Strauss syndrome diagnostic study of choice: Difference between revisions
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=== Diagnostic Criteria === | === Diagnostic Criteria === | ||
According to the '''American College of Rheumatology classification criteria''' <ref name="pmid2202307">{{cite journal| author=Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP et al.| title=The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). | journal=Arthritis Rheum | year= 1990 | volume= 33 | issue= 8 | pages= 1094-100 | pmid=2202307 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2202307 }}</ref> | |||
{| class="wikitable" | |||
|[[Asthma]] | |||
[[Eosinophilia]] | |||
[[Polyneuropathy]] or [[Mononeuropathy]] | |||
Non fixed pulmonary infiltrates | |||
[[Paranasal sinus]] that is abnormal | |||
[[Eosinophil granulocyte|Eosinophils]] that are extravascular | |||
| | |||
Patients must express 4 out the 6 criteria to be diagnosed with [[eosinophilic granulomatosis with polyangiitis]]. | |||
|} | |||
According to '''Lanham diagnostic criteria''' <ref name="pmid6366453">{{cite journal| author=Lanham JG, Elkon KB, Pusey CD, Hughes GR| title=Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome. | journal=Medicine (Baltimore) | year= 1984 | volume= 63 | issue= 2 | pages= 65-81 | pmid=6366453 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6366453 }}</ref> | |||
{| class="wikitable" | |||
|[[Asthma]] | |||
[[Eosinophilia]] peak of >1.5x10<sup>9</sup> cell/L or >10% of the total [[White blood cells|WBC]] | |||
[[Vasculitis|Systemic vasculitis]], two or greater extra pulmonary sites | |||
| | |||
All 3 criteria’s need to be present | |||
|} | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Study of Choice
Study of choice
- [Name of the investigation] is the gold standard test for the diagnosis of [disease name].
- The following result of [gold standard test] is confirmatory of [disease name]:
- Result 1
- Result 2
- The [name of the investigation] should be performed when:
- The patient presented with symptoms/signs 1. 2, 3.
- A positive [test] is detected in the patient.
- [Name of the investigation] is the gold standard test for the diagnosis of [disease name].
- The diagnostic study of choice for [disease name] is [name of the investigation].
- There is no single diagnostic study of choice for the diagnosis of [disease name].
- There is no single diagnostic study of choice for the diagnosis of [disease name], but [disease name] can be diagnosed based on [name of the investigation 1] and [name of the investigation 2].
- [Disease name] is mainly diagnosed based on clinical presentation.
- Investigations:
- Among patients who present with clinical signs of [disease name], the [investigation name] is the most specific test for the diagnosis.
- Among patients who present with clinical signs of [disease name], the [investigation name] is the most sensitive test for diagnosis.
- Among patients who present with clinical signs of [disease name], the [investigation name] is the most efficient test for diagnosis.
The comparison of various diagnostic studies for [disease name]
| Test | Sensitivity | Specificity |
|---|---|---|
| Test 1 | ✔ | ...% |
| Test 2 | ...% | ✔ |
✔= The best test based on the feature
Diagnostic results
The following result of [investigation name] is confirmatory of [disease name]:
- Result 1
- Result 2
Sequence of Diagnostic Studies
The [name of investigation] should be performed when:
- The patient presented with symptoms/signs 1, 2, and 3 as the first step of diagnosis.
- A positive [test] is detected in the patient, to confirm the diagnosis.
Diagnostic Criteria
According to the American College of Rheumatology classification criteria [1]
| Asthma
Polyneuropathy or Mononeuropathy Non fixed pulmonary infiltrates Paranasal sinus that is abnormal Eosinophils that are extravascular |
Patients must express 4 out the 6 criteria to be diagnosed with eosinophilic granulomatosis with polyangiitis. |
According to Lanham diagnostic criteria [2]
| Asthma
Eosinophilia peak of >1.5x109 cell/L or >10% of the total WBC Systemic vasculitis, two or greater extra pulmonary sites |
All 3 criteria’s need to be present |
References
- ↑ Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP; et al. (1990). "The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis)". Arthritis Rheum. 33 (8): 1094–100. PMID 2202307.
- ↑ Lanham JG, Elkon KB, Pusey CD, Hughes GR (1984). "Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome". Medicine (Baltimore). 63 (2): 65–81. PMID 6366453.