Neonatal jaundice causes: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
Line 9: | Line 9: | ||
=== Common causes === | === Common causes === | ||
* Common causes of neonatal jaundice include the following: | * Common causes of neonatal jaundice include the following:<ref>{{cite journal|last=Poland|first=R L|coauthors=Schultz GE, Gayatri G|title=High milk lipase activity associated with breastmilk jaundice.|journal=Pediatr Res|year=1980|volume=14|pages=1328–31}}</ref><ref>{{cite journal|last=Murphy|first=J F|coauthors=Hughes I, Verrier Jones ER, Gaskell S, Pike AW.|title=Pregnanediols and breast-milk jaundice.|journal=Arch Dis Child|year=1981|volume=56|pages=474–76}}</ref> | ||
** Increase bilirubin production due to hemolysis. Hemolytic causes include the following: | ** Increase bilirubin production due to hemolysis. Hemolytic causes include the following: | ||
** Intrinsic causes of hemolysis: | ** Intrinsic causes of hemolysis: | ||
Line 30: | Line 30: | ||
=== Less common causes === | === Less common causes === | ||
* Less common causes of neonatal jaundice include the following disorders: | * Less common causes of neonatal jaundice include the following disorders:<ref>{{cite journal|last=Kumral|first=A|coauthors=Ozkan H, Duman N, et al.|title=Breast milk jaundice correlates with high levels of epidermal growth factor|journal=Pediatr Res|year=2009|volume=66|pages=218–21}}</ref><ref>{{cite journal|last=Arias|first=IM|coauthors=Gartner LM, Seifter S, Furman M|title=Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid, pregnane-3(alpha), 20(beta)-diol in maternal milk that inhibits glucuronide formation in vitro.|journal=J Clin Invest|year=1964|volume=43|pages=2037–47}}</ref> | ||
** Non-hemolytic causes | ** Non-hemolytic causes | ||
***[[Cephalohematoma]] | ***[[Cephalohematoma]] | ||
Line 52: | Line 52: | ||
* Post-hepatic | * Post-hepatic | ||
**[[Biliary atresia]] | **[[Biliary atresia]] | ||
*[[Bile duct]] obstruction | *[[Bile duct]] obstruction | ||
==References== | ==References== |
Revision as of 17:21, 4 February 2018
Neonatal jaundice Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Neonatal jaundice causes On the Web |
American Roentgen Ray Society Images of Neonatal jaundice causes |
Risk calculators and risk factors for Neonatal jaundice causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Neonatal jaundice is caused by hemolysis of the RBCs mainly due to either intravascular causes or extravascular causes. Other causes include nonhemolytic causes as cephalosporines induced jaundice, genetic mutations of the UGT enzyme, and hepatic causes.
Causes
Common causes
- Common causes of neonatal jaundice include the following:[1][2]
- Increase bilirubin production due to hemolysis. Hemolytic causes include the following:
- Intrinsic causes of hemolysis:
- Systemic contitions:
- Enzyme conditions
- Glucose-6-phosphate dehydrogenase deficiency (also called G6PD deficiency)
- Pyruvate kinase deficiency
- Globin synthesis defect
- Extrinsic causes of hemolysis:
- Alloimmunity (The neonatal or cord blood gives a positive direct Coombs test and the maternal blood gives a positive indirect Coombs test)
- Hemolytic disease of the newborn (ABO)
- Rh disease
- Extrinsic causes of hemolysis:
Less common causes
- Hepatic causes
- Infections
- Metabolic
- Drugs- Losartan and Hydrochlorothiazide
- Total parenteral nutrition
- Idiopathic
- Post-hepatic
- Bile duct obstruction
References
- ↑ Poland, R L (1980). "High milk lipase activity associated with breastmilk jaundice". Pediatr Res. 14: 1328–31. Unknown parameter
|coauthors=
ignored (help) - ↑ Murphy, J F (1981). "Pregnanediols and breast-milk jaundice". Arch Dis Child. 56: 474–76. Unknown parameter
|coauthors=
ignored (help) - ↑ Kumral, A (2009). "Breast milk jaundice correlates with high levels of epidermal growth factor". Pediatr Res. 66: 218–21. Unknown parameter
|coauthors=
ignored (help) - ↑ Arias, IM (1964). "Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid, pregnane-3(alpha), 20(beta)-diol in maternal milk that inhibits glucuronide formation in vitro". J Clin Invest. 43: 2037–47. Unknown parameter
|coauthors=
ignored (help)