SLC22A2: Difference between revisions

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{{Infobox_gene}}
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'''Solute carrier family 22 member 2''' is a [[protein]] that in humans is encoded by the ''SLC22A2'' [[gene]].<ref name="pmid9605850">{{cite journal | vauthors = Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M | title = The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26 | journal = Cytogenet Cell Genet | volume = 79 | issue = 3-4 | pages = 198–200 |date=Jun 1998 | pmid = 9605850 | pmc =  | doi =10.1159/000134720 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Solute carrier family 22 (organic cation transporter), member 2
| HGNCid = 10966
| Symbol = SLC22A2
| AltSymbols =; OCT2; MGC32628
| OMIM = 602608
| ECnumber = 
| Homologene = 68293
| MGIid = 1335072
| GeneAtlas_image1 = PBB_GE_SLC22A2_207429_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015075 |text = ion transmembrane transporter activity}} {{GNF_GO|id=GO:0015101 |text = organic cation transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0007589 |text = fluid secretion}} {{GNF_GO|id=GO:0015695 |text = organic cation transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6582
    | Hs_Ensembl = ENSG00000112499
    | Hs_RefseqProtein = NP_003049
    | Hs_RefseqmRNA = NM_003058
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 160557784
    | Hs_GenLoc_end = 160618660
    | Hs_Uniprot = 
    | Mm_EntrezGene = 20518
    | Mm_Ensembl = ENSMUSG00000040966
    | Mm_RefseqmRNA = NM_013667
    | Mm_RefseqProtein = NP_038695
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 12427547
    | Mm_GenLoc_end = 12471862
    | Mm_Uniprot =   
  }}
}}
'''Solute carrier family 22 (organic cation transporter), member 2''', also known as '''SLC22A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582| accessdate = }}</ref>
| summary_text = Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal  | author=Berkhout B, Jeang KT |title=Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat. |journal=J. Virol. |volume=66 |issue= 1 |pages= 139-49 |year= 1992 |pmid= 1727476 |doi=  }}
*{{cite journal  | vauthors=Berkhout B, Jeang KT |title=Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat. |journal=J. Virol. |volume=66 |issue= 1 |pages= 139–49 |year= 1992 |pmid= 1727476 |doi= | pmc=238269 }}
*{{cite journal | author=Jeang KT, Chun R, Lin NH, ''et al.'' |title=In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. |journal=J. Virol. |volume=67 |issue= 10 |pages= 6224-33 |year= 1993 |pmid= 7690421 |doi=  }}
*{{cite journal   |vauthors=Jeang KT, Chun R, Lin NH, etal |title=In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. |journal=J. Virol. |volume=67 |issue= 10 |pages= 6224–33 |year= 1993 |pmid= 7690421 |doi= | pmc=238044 }}
*{{cite journal  | author=Liu YZ, Lania L, Latchman DS |title=Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor. |journal=AIDS |volume=10 |issue= 12 |pages= 1323-9 |year= 1997 |pmid= 8902060 |doi=  }}
*{{cite journal  | vauthors=Liu YZ, Lania L, Latchman DS |title=Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor. |journal=AIDS |volume=10 |issue= 12 |pages= 1323–9 |year= 1997 |pmid= 8902060 |doi=10.1097/00002030-199610000-00003 }}
*{{cite journal  | author=Liu YZ, Latchman DS |title=The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat. |journal=Biochem. J. |volume=322 ( Pt 1) |issue=  |pages= 155-8 |year= 1997 |pmid= 9078256 |doi=  }}
*{{cite journal  | vauthors=Liu YZ, Latchman DS |title=The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat. |journal=Biochem. J. |volume=322 |issue=  1|pages= 155–8 |year= 1997 |pmid= 9078256 |doi= | pmc=1218171 }}
*{{cite journal | author=Gorboulev V, Ulzheimer JC, Akhoundova A, ''et al.'' |title=Cloning and characterization of two human polyspecific organic cation transporters. |journal=DNA Cell Biol. |volume=16 |issue= 7 |pages= 871-81 |year= 1997 |pmid= 9260930 |doi=  }}
*{{cite journal   |vauthors=Gorboulev V, Ulzheimer JC, Akhoundova A, etal |title=Cloning and characterization of two human polyspecific organic cation transporters. |journal=DNA Cell Biol. |volume=16 |issue= 7 |pages= 871–81 |year= 1997 |pmid= 9260930 |doi=10.1089/dna.1997.16.871 }}
*{{cite journal | author=Koehler MR, Wissinger B, Gorboulev V, ''et al.'' |title=The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 198-200 |year= 1998 |pmid= 9605850 |doi=  }}
*{{cite journal   |vauthors=Busch AE, Karbach U, Miska D, etal |title=Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. |journal=Mol. Pharmacol. |volume=54 |issue= 2 |pages= 342–52 |year= 1998 |pmid= 9687576 |doi=  }}
*{{cite journal  | author=Busch AE, Karbach U, Miska D, ''et al.'' |title=Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. |journal=Mol. Pharmacol. |volume=54 |issue= 2 |pages= 342-52 |year= 1998 |pmid= 9687576 |doi= }}
*{{cite journal  | vauthors=Verhaagh S, Schweifer N, Barlow DP, Zwart R |title=Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. |journal=Genomics |volume=55 |issue= 2 |pages= 209–18 |year= 1999 |pmid= 9933568 |doi= 10.1006/geno.1998.5639 }}
*{{cite journal  | author=Verhaagh S, Schweifer N, Barlow DP, Zwart R |title=Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. |journal=Genomics |volume=55 |issue= 2 |pages= 209-18 |year= 1999 |pmid= 9933568 |doi= 10.1006/geno.1998.5639 }}
*{{cite journal  | vauthors=Gründemann D, Schömig E |title=Gene structures of the human non-neuronal monoamine transporters EMT and OCT2. |journal=Hum. Genet. |volume=106 |issue= 6 |pages= 627–35 |year= 2000 |pmid= 10942111 |doi=10.1007/s004390050035  }}
*{{cite journal | author=Gründemann D, Schömig E |title=Gene structures of the human non-neuronal monoamine transporters EMT and OCT2. |journal=Hum. Genet. |volume=106 |issue= 6 |pages= 627-35 |year= 2000 |pmid= 10942111 |doi= }}
*{{cite journal   |vauthors=Pietig G, Mehrens T, Hirsch JR, etal |title=Properties and regulation of organic cation transport in freshly isolated human proximal tubules. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33741–6 |year= 2001 |pmid= 11447227 |doi= 10.1074/jbc.M104617200 }}
*{{cite journal | author=Pietig G, Mehrens T, Hirsch JR, ''et al.'' |title=Properties and regulation of organic cation transport in freshly isolated human proximal tubules. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33741-6 |year= 2001 |pmid= 11447227 |doi= 10.1074/jbc.M104617200 }}
*{{cite journal   |vauthors=Boehm J, He Y, Greiner A, etal |title=Regulation of BOB.1/OBF.1 stability by SIAH. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4153–62 |year= 2001 |pmid= 11483518 |doi= 10.1093/emboj/20.15.4153  | pmc=149152 }}
*{{cite journal  | author=Boehm J, He Y, Greiner A, ''et al.'' |title=Regulation of BOB.1/OBF.1 stability by SIAH. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4153-62 |year= 2001 |pmid= 11483518 |doi= 10.1093/emboj/20.15.4153 }}
*{{cite journal  | vauthors=Barendt WM, Wright SH |title=The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22491–6 |year= 2002 |pmid= 11953440 |doi= 10.1074/jbc.M203114200 }}
*{{cite journal | author=Barendt WM, Wright SH |title=The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22491-6 |year= 2002 |pmid= 11953440 |doi= 10.1074/jbc.M203114200 }}
*{{cite journal   |vauthors=Urakami Y, Akazawa M, Saito H, etal |title=cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 7 |pages= 1703–10 |year= 2002 |pmid= 12089365 |doi=10.1097/01.ASN.0000019413.78751.46  }}
*{{cite journal | author=Urakami Y, Akazawa M, Saito H, ''et al.'' |title=cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 7 |pages= 1703-10 |year= 2002 |pmid= 12089365 |doi=  }}
*{{cite journal   |vauthors=Leabman MK, Huang CC, Kawamoto M, etal |title=Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. |journal=Pharmacogenetics |volume=12 |issue= 5 |pages= 395–405 |year= 2003 |pmid= 12142729 |doi=10.1097/00008571-200207000-00007 }}
*{{cite journal | author=Leabman MK, Huang CC, Kawamoto M, ''et al.'' |title=Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. |journal=Pharmacogenetics |volume=12 |issue= 5 |pages= 395-405 |year= 2003 |pmid= 12142729 |doi= }}
*{{cite journal   |vauthors=Cetinkaya I, Ciarimboli G, Yalçinkaya G, etal |title=Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 2 |pages= F293–302 |year= 2003 |pmid= 12388397 |doi= 10.1152/ajprenal.00251.2002 }}
*{{cite journal | author=Cetinkaya I, Ciarimboli G, Yalçinkaya G, ''et al.'' |title=Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 2 |pages= F293-302 |year= 2003 |pmid= 12388397 |doi= 10.1152/ajprenal.00251.2002 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gründemann D, Hahne C, Berkels R, Schömig E |title=Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 2 |pages= 810–7 |year= 2003 |pmid= 12538837 |doi= 10.1124/jpet.102.044404 }}
*{{cite journal | author=Gründemann D, Hahne C, Berkels R, Schömig E |title=Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 2 |pages= 810-7 |year= 2003 |pmid= 12538837 |doi= 10.1124/jpet.102.044404 }}
*{{cite journal   |vauthors=Bottalico B, Larsson I, Brodszki J, etal |title=Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies. |journal=Placenta |volume=25 |issue= 6 |pages= 518–29 |year= 2004 |pmid= 15135235 |doi= 10.1016/j.placenta.2003.10.017 }}
*{{cite journal | author=Bottalico B, Larsson I, Brodszki J, ''et al.'' |title=Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies. |journal=Placenta |volume=25 |issue= 6 |pages= 518-29 |year= 2004 |pmid= 15135235 |doi= 10.1016/j.placenta.2003.10.017 }}
*{{cite journal   |vauthors=Lips KS, Volk C, Schmitt BM, etal |title=Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. |journal=Am. J. Respir. Cell Mol. Biol. |volume=33 |issue= 1 |pages= 79–88 |year= 2005 |pmid= 15817714 |doi= 10.1165/rcmb.2004-0363OC }}
*{{cite journal | author=Lips KS, Volk C, Schmitt BM, ''et al.'' |title=Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. |journal=Am. J. Respir. Cell Mol. Biol. |volume=33 |issue= 1 |pages= 79-88 |year= 2005 |pmid= 15817714 |doi= 10.1165/rcmb.2004-0363OC }}
*{{cite journal   |vauthors=Jiang W, Prokopenko O, Wong L, etal |title=IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6496–508 |year= 2005 |pmid= 16024787 |doi= 10.1128/MCB.25.15.6496-6508.2005 | pmc=1190334 }}
*{{cite journal | author=Jiang W, Prokopenko O, Wong L, ''et al.'' |title=IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6496-508 |year= 2005 |pmid= 16024787 |doi= 10.1128/MCB.25.15.6496-6508.2005 }}
}}
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{{membrane-protein-stub}}
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{{Membrane transport proteins}}
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[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
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Latest revision as of 06:28, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.[1][2]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.[2]

See also

References

  1. ↑ Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.
  2. ↑ 2.0 2.1 "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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