RAD1 homolog: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cell cycle checkpoint protein RAD1''' is a [[protein]] that in humans is encoded by the ''RAD1'' [[gene]].<ref name="pmid9716408">{{cite journal | vauthors = Freire R, Murguía JR, Tarsounas M, Lowndes NF, Moens PB, Jackson SP | title = Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis | journal = Genes Dev | volume = 12 | issue = 16 | pages = 2560–73 | date = September 1998 | pmid = 9716408 | pmc = 317084 | doi = 10.1101/gad.12.16.2560 }}</ref><ref name="pmid9828137">{{cite journal | vauthors = Bluyssen HA, van Os RI, Naus NC, Jaspers I, Hoeijmakers JH, de Klein A | title = A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene | journal = Genomics | volume = 54 | issue = 2 | pages = 331–7 | date = January 1999 | pmid = 9828137 | pmc = | doi = 10.1006/geno.1998.5582 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAD1 RAD1 homolog (S. pombe)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5810| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = RAD1 homolog (S. pombe)
| HGNCid = 9806
| Symbol = RAD1
| AltSymbols =; HRAD1; REC1
| OMIM = 603153
| ECnumber = 
| Homologene = 37695
| MGIid = 1316678
| GeneAtlas_image1 = PBB_GE_RAD1_204460_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAD1_204461_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_RAD1_210216_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008408 |text = 3'-5' exonuclease activity}} {{GNF_GO|id=GO:0008853 |text = exodeoxyribonuclease III activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0000077 |text = DNA damage checkpoint}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0007128 |text = meiotic prophase I}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5810
    | Hs_Ensembl = ENSG00000113456
    | Hs_RefseqProtein = NP_002844
    | Hs_RefseqmRNA = NM_002853
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 34941122
    | Hs_GenLoc_end = 34954139
    | Hs_Uniprot = O60671
    | Mm_EntrezGene = 19355
    | Mm_Ensembl = ENSMUSG00000022248
    | Mm_RefseqmRNA = NM_011232
    | Mm_RefseqProtein = NP_035362
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 10430759
    | Mm_GenLoc_end = 10440784
    | Mm_Uniprot = Q9QWZ1
  }}
}}
'''RAD1 homolog (S. pombe)''', also known as '''RAD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAD1 RAD1 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5810| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.<ref name="entrez">{{cite web | title = Entrez Gene: RAD1 RAD1 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5810| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Bardwell AJ, Bardwell L, Johnson DK, Friedberg EC |title=Yeast DNA recombination and repair proteins Rad1 and Rad10 constitute a complex in vivo mediated by localized hydrophobic domains. |journal=Mol. Microbiol. |volume=8 |issue= 6 |pages= 1177-88 |year= 1993 |pmid= 8361362 |doi=  }}
*{{cite journal  | author=Parker AE, Van de Weyer I, Laus MC, ''et al.'' |title=A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18332-9 |year= 1998 |pmid= 9660799 |doi=  }}
*{{cite journal  | author=Udell CM, Lee SK, Davey S |title=HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene. |journal=Nucleic Acids Res. |volume=26 |issue= 17 |pages= 3971-6 |year= 1998 |pmid= 9705507 |doi=  }}
*{{cite journal  | author=Freire R, Murguía JR, Tarsounas M, ''et al.'' |title=Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. |journal=Genes Dev. |volume=12 |issue= 16 |pages= 2560-73 |year= 1998 |pmid= 9716408 |doi=  }}
*{{cite journal  | author=Bluyssen HA, van Os RI, Naus NC, ''et al.'' |title=A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. |journal=Genomics |volume=54 |issue= 2 |pages= 331-7 |year= 1999 |pmid= 9828137 |doi= 10.1006/geno.1998.5582 }}
*{{cite journal  | author=Marathi UK, Dahlen M, Sunnerhagen P, ''et al.'' |title=RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene. |journal=Genomics |volume=54 |issue= 2 |pages= 344-7 |year= 1999 |pmid= 9828139 |doi= 10.1006/geno.1998.5589 }}
*{{cite journal  | author=Volkmer E, Karnitz LM |title=Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 567-70 |year= 1999 |pmid= 9872989 |doi=  }}
*{{cite journal  | author=Dean FB, Lian L, O'Donnell M |title=cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. |journal=Genomics |volume=54 |issue= 3 |pages= 424-36 |year= 1999 |pmid= 9878245 |doi= 10.1006/geno.1998.5587 }}
*{{cite journal  | author=St Onge RP, Udell CM, Casselman R, Davey S |title=The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. |journal=Mol. Biol. Cell |volume=10 |issue= 6 |pages= 1985-95 |year= 1999 |pmid= 10359610 |doi=  }}
*{{cite journal  | author=Hang H, Lieberman HB |title=Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression. |journal=Genomics |volume=65 |issue= 1 |pages= 24-33 |year= 2000 |pmid= 10777662 |doi= 10.1006/geno.2000.6142 }}
*{{cite journal  | author=Cai RL, Yan-Neale Y, Cueto MA, ''et al.'' |title=HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27909-16 |year= 2000 |pmid= 10846170 |doi= 10.1074/jbc.M000168200 }}
*{{cite journal  | author=Burtelow MA, Kaufmann SH, Karnitz LM |title=Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26343-8 |year= 2000 |pmid= 10852904 |doi= 10.1074/jbc.M001244200 }}
*{{cite journal  | author=Rauen M, Burtelow MA, Dufault VM, Karnitz LM |title=The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29767-71 |year= 2000 |pmid= 10884395 |doi= 10.1074/jbc.M005782200 }}
*{{cite journal  | author=Burtelow MA, Roos-Mattjus PM, Rauen M, ''et al.'' |title=Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25903-9 |year= 2001 |pmid= 11340080 |doi= 10.1074/jbc.M102946200 }}
*{{cite journal  | author=Bao S, Tibbetts RS, Brumbaugh KM, ''et al.'' |title=ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. |journal=Nature |volume=411 |issue= 6840 |pages= 969-74 |year= 2001 |pmid= 11418864 |doi= 10.1038/35082110 }}
*{{cite journal  | author=Xiang SL, Kumano T, Iwasaki SI, ''et al.'' |title=The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 4 |pages= 932-40 |year= 2001 |pmid= 11573955 |doi= 10.1006/bbrc.2001.5685 }}
*{{cite journal  | author=Zou L, Cortez D, Elledge SJ |title=Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 198-208 |year= 2002 |pmid= 11799063 |doi= 10.1101/gad.950302 }}
*{{cite journal  | author=Griffith JD, Lindsey-Boltz LA, Sancar A |title=Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15233-6 |year= 2002 |pmid= 11907025 |doi= 10.1074/jbc.C200129200 }}
*{{cite journal  | author=Hang H, Zhang Y, Dunbrack RL, ''et al.'' |title=Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1. |journal=Genomics |volume=79 |issue= 4 |pages= 487-92 |year= 2002 |pmid= 11944979 |doi= 10.1006/geno.2002.6737 }}
*{{cite journal  | author=Hirai I, Wang HG |title=A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25722-7 |year= 2002 |pmid= 11994305 |doi= 10.1074/jbc.M203079200 }}
}}
{{refend}}


{{protein-stub}}
RAD1 homolog has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
* [[HUS1]],<ref name = pmid9872989/><ref name = pmid11944979>{{cite journal | vauthors = Hang H, Zhang Y, Dunbrack RL, Wang C, Lieberman HB | title = Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1 | journal = Genomics | volume = 79 | issue = 4 | pages = 487–92 | date = April 2002 | pmid = 11944979 | doi = 10.1006/geno.2002.6737 }}</ref>
* [[RAD17]],<ref name = pmid12578958>{{cite journal | vauthors = Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A | title = Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 4 | pages = 1633–8 | date = February 2003 | pmid = 12578958 | pmc = 149884 | doi = 10.1073/pnas.0437927100 }}</ref><ref name = pmid10884395>{{cite journal | vauthors = Rauen M, Burtelow MA, Dufault VM, Karnitz LM | title = The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9 | journal = J. Biol. Chem. | volume = 275 | issue = 38 | pages = 29767–71 | date = September 2000 | pmid = 10884395 | doi = 10.1074/jbc.M005782200 }}</ref><ref name = pmid11418864>{{cite journal | vauthors = Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF | title = ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses | journal = Nature | volume = 411 | issue = 6840 | pages = 969–74 | date = June 2001 | pmid = 11418864 | doi = 10.1038/35082110 }}</ref>  and
* [[RAD9A]],<ref name = pmid9872989>{{cite journal | vauthors = Volkmer E, Karnitz LM | title = Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex | journal = J. Biol. Chem. | volume = 274 | issue = 2 | pages = 567–70 | date = January 1999 | pmid = 9872989 | doi =  10.1074/jbc.274.2.567}}</ref><ref name = pmid14611806>{{cite journal | vauthors = Dufault VM, Oestreich AJ, Vroman BT, Karnitz LM | title = Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene | journal = Genomics | volume = 82 | issue = 6 | pages = 644–51 | date = Dec 2003 | pmid = 14611806 | doi =  10.1016/s0888-7543(03)00200-3}}</ref><ref name = pmid11907025>{{cite journal | vauthors = Griffith JD, Lindsey-Boltz LA, Sancar A | title = Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy | journal = J. Biol. Chem. | volume = 277 | issue = 18 | pages = 15233–6 | date = May 2002 | pmid = 11907025 | doi = 10.1074/jbc.C200129200 }}</ref><ref name = pmid11994305>{{cite journal | vauthors = Hirai I, Wang HG | title = A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex | journal = J. Biol. Chem. | volume = 277 | issue = 28 | pages = 25722–7 | date = July 2002 | pmid = 11994305 | doi = 10.1074/jbc.M203079200 }}</ref><ref name = pmid11572977>{{cite journal | vauthors = Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A | title = Purification and characterization of human DNA damage checkpoint Rad complexes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 20 | pages = 11236–41 | date = September 2001 | pmid = 11572977 | pmc = 58713 | doi = 10.1073/pnas.201373498 }}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Bardwell AJ, Bardwell L, Johnson DK, Friedberg EC | title = Yeast DNA recombination and repair proteins Rad1 and Rad10 constitute a complex in vivo mediated by localized hydrophobic domains. | journal = Mol. Microbiol. | volume = 8 | issue = 6 | pages = 1177–88 | year = 1993 | pmid = 8361362 | doi = 10.1111/j.1365-2958.1993.tb01662.x }}
* {{cite journal | vauthors = Parker AE, Van de Weyer I, Laus MC, Oostveen I, Yon J, Verhasselt P, Luyten WH | title = A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18332–9 | year = 1998 | pmid = 9660799 | doi = 10.1074/jbc.273.29.18332 }}
* {{cite journal | vauthors = Udell CM, Lee SK, Davey S | title = HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene. | journal = Nucleic Acids Res. | volume = 26 | issue = 17 | pages = 3971–6 | year = 1998 | pmid = 9705507 | pmc = 147814 | doi = 10.1093/nar/26.17.3971 }}
* {{cite journal | vauthors = Marathi UK, Dahlen M, Sunnerhagen P, Romero AV, Ramagli LS, Siciliano MJ, Li L, Legerski RJ | title = RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene. | journal = Genomics | volume = 54 | issue = 2 | pages = 344–7 | year = 1999 | pmid = 9828139 | doi = 10.1006/geno.1998.5589 }}
* {{cite journal | vauthors = Volkmer E, Karnitz LM | title = Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex. | journal = J. Biol. Chem. | volume = 274 | issue = 2 | pages = 567–70 | year = 1999 | pmid = 9872989 | doi = 10.1074/jbc.274.2.567 }}
* {{cite journal | vauthors = Dean FB, Lian L, O'Donnell M | title = cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. | journal = Genomics | volume = 54 | issue = 3 | pages = 424–36 | year = 1999 | pmid = 9878245 | doi = 10.1006/geno.1998.5587 }}
* {{cite journal | vauthors = St Onge RP, Udell CM, Casselman R, Davey S | title = The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. | journal = Mol. Biol. Cell | volume = 10 | issue = 6 | pages = 1985–95 | year = 1999 | pmid = 10359610 | pmc = 25401 | doi = 10.1091/mbc.10.6.1985 }}
* {{cite journal | vauthors = Hang H, Lieberman HB | title = Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression. | journal = Genomics | volume = 65 | issue = 1 | pages = 24–33 | year = 2000 | pmid = 10777662 | doi = 10.1006/geno.2000.6142 }}
* {{cite journal | vauthors = Cai RL, Yan-Neale Y, Cueto MA, Xu H, Cohen D | title = HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. | journal = J. Biol. Chem. | volume = 275 | issue = 36 | pages = 27909–16 | year = 2000 | pmid = 10846170 | doi = 10.1074/jbc.M000168200 }}
* {{cite journal | vauthors = Burtelow MA, Kaufmann SH, Karnitz LM | title = Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage. | journal = J. Biol. Chem. | volume = 275 | issue = 34 | pages = 26343–8 | year = 2000 | pmid = 10852904 | doi = 10.1074/jbc.M001244200 }}
* {{cite journal | vauthors = Rauen M, Burtelow MA, Dufault VM, Karnitz LM | title = The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. | journal = J. Biol. Chem. | volume = 275 | issue = 38 | pages = 29767–71 | year = 2000 | pmid = 10884395 | doi = 10.1074/jbc.M005782200 }}
* {{cite journal | vauthors = Burtelow MA, Roos-Mattjus PM, Rauen M, Babendure JR, Karnitz LM | title = Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex. | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 25903–9 | year = 2001 | pmid = 11340080 | doi = 10.1074/jbc.M102946200 }}
* {{cite journal | vauthors = Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF | title = ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. | journal = Nature | volume = 411 | issue = 6840 | pages = 969–74 | year = 2001 | pmid = 11418864 | doi = 10.1038/35082110 }}
* {{cite journal | vauthors = Xiang SL, Kumano T, Iwasaki SI, Sun X, Yoshioka K, Yamamoto KC | title = The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. | journal = Biochem. Biophys. Res. Commun. | volume = 287 | issue = 4 | pages = 932–40 | year = 2001 | pmid = 11573955 | doi = 10.1006/bbrc.2001.5685 }}
* {{cite journal | vauthors = Zou L, Cortez D, Elledge SJ | title = Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. | journal = Genes Dev. | volume = 16 | issue = 2 | pages = 198–208 | year = 2002 | pmid = 11799063 | pmc = 155323 | doi = 10.1101/gad.950302 }}
* {{cite journal | vauthors = Griffith JD, Lindsey-Boltz LA, Sancar A | title = Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. | journal = J. Biol. Chem. | volume = 277 | issue = 18 | pages = 15233–6 | year = 2002 | pmid = 11907025 | doi = 10.1074/jbc.C200129200 }}
* {{cite journal | vauthors = Hang H, Zhang Y, Dunbrack RL, Wang C, Lieberman HB | title = Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1. | journal = Genomics | volume = 79 | issue = 4 | pages = 487–92 | year = 2002 | pmid = 11944979 | doi = 10.1006/geno.2002.6737 }}
* {{cite journal | vauthors = Hirai I, Wang HG | title = A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex. | journal = J. Biol. Chem. | volume = 277 | issue = 28 | pages = 25722–7 | year = 2002 | pmid = 11994305 | doi = 10.1074/jbc.M203079200 }}
{{Refend}}

Latest revision as of 01:48, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene.[1][2][3]

Function

This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.[3]

Interactions

RAD1 homolog has been shown to interact with:

References

  1. ↑ Freire R, Murguía JR, Tarsounas M, Lowndes NF, Moens PB, Jackson SP (September 1998). "Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis". Genes Dev. 12 (16): 2560–73. doi:10.1101/gad.12.16.2560. PMC 317084. PMID 9716408.
  2. ↑ Bluyssen HA, van Os RI, Naus NC, Jaspers I, Hoeijmakers JH, de Klein A (January 1999). "A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene". Genomics. 54 (2): 331–7. doi:10.1006/geno.1998.5582. PMID 9828137.
  3. ↑ 3.0 3.1 "Entrez Gene: RAD1 RAD1 homolog (S. pombe)".
  4. ↑ 4.0 4.1 Volkmer E, Karnitz LM (January 1999). "Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex". J. Biol. Chem. 274 (2): 567–70. doi:10.1074/jbc.274.2.567. PMID 9872989.
  5. ↑ Hang H, Zhang Y, Dunbrack RL, Wang C, Lieberman HB (April 2002). "Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1". Genomics. 79 (4): 487–92. doi:10.1006/geno.2002.6737. PMID 11944979.
  6. ↑ Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A (February 2003). "Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1633–8. doi:10.1073/pnas.0437927100. PMC 149884. PMID 12578958.
  7. ↑ Rauen M, Burtelow MA, Dufault VM, Karnitz LM (September 2000). "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9". J. Biol. Chem. 275 (38): 29767–71. doi:10.1074/jbc.M005782200. PMID 10884395.
  8. ↑ Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF (June 2001). "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses". Nature. 411 (6840): 969–74. doi:10.1038/35082110. PMID 11418864.
  9. ↑ Dufault VM, Oestreich AJ, Vroman BT, Karnitz LM (Dec 2003). "Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene". Genomics. 82 (6): 644–51. doi:10.1016/s0888-7543(03)00200-3. PMID 14611806.
  10. ↑ Griffith JD, Lindsey-Boltz LA, Sancar A (May 2002). "Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy". J. Biol. Chem. 277 (18): 15233–6. doi:10.1074/jbc.C200129200. PMID 11907025.
  11. ↑ Hirai I, Wang HG (July 2002). "A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex". J. Biol. Chem. 277 (28): 25722–7. doi:10.1074/jbc.M203079200. PMID 11994305.
  12. ↑ Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A (September 2001). "Purification and characterization of human DNA damage checkpoint Rad complexes". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11236–41. doi:10.1073/pnas.201373498. PMC 58713. PMID 11572977.

Further reading

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