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{{Infobox_gene}}
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'''NGFI-A-binding protein 1''' is a [[protein]] that in humans is encoded by the ''NAB1'' [[gene]].<ref name="pmid7624335">{{cite journal | vauthors = Russo MW, Sevetson BR, Milbrandt J | title = Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription | journal = Proc Natl Acad Sci U S A | volume = 92 | issue = 15 | pages = 6873–7 |date=Aug 1995 | pmid = 7624335 | pmc = 41432 | doi =10.1073/pnas.92.15.6873 }}</ref><ref name="pmid8668170">{{cite journal | vauthors = Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J | title = NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli | journal = Mol Cell Biol | volume = 16 | issue = 7 | pages = 3545–53 |date=Aug 1996 | pmid = 8668170 | pmc = 231349 | doi = }}</ref><ref name="pmid9418898">{{cite journal | vauthors = Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J | title = Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain | journal = Mol Cell Biol | volume = 18 | issue = 1 | pages = 512–24 |date=Jan 1998 | pmid = 9418898 | pmc = 115883 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4664| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = NGFI-A binding protein 1 (EGR1 binding protein 1)
| HGNCid = 7626
| Symbol = NAB1
| AltSymbols =;
| OMIM = 600800
| ECnumber =
| Homologene = 4352
| MGIid = 107564
| GeneAtlas_image1 = PBB_GE_NAB1_209272_at_tn.png
| GeneAtlas_image2 = PBB_GE_NAB1_208047_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_NAB1_211139_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001958 |text = endochondral ossification}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0014037 |text = Schwann cell differentiation}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0042552 |text = myelination}} {{GNF_GO|id=GO:0045682 |text = regulation of epidermis development}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4664
    | Hs_Ensembl = ENSG00000138386
    | Hs_RefseqProtein = NP_005957
    | Hs_RefseqmRNA = NM_005966
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 191222093
    | Hs_GenLoc_end = 191265734
    | Hs_Uniprot = Q13506
    | Mm_EntrezGene = 17936
    | Mm_Ensembl = ENSMUSG00000002881
    | Mm_RefseqmRNA = NM_008667
    | Mm_RefseqProtein = NP_032693
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 52402421
    | Mm_GenLoc_end = 52444905
    | Mm_Uniprot = Q99J24
  }}
}}
'''NGFI-A binding protein 1 (EGR1 binding protein 1)''', also known as '''NAB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4664| accessdate = }}</ref>


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| section_title =
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}}
==Interactions==
NAB1 has been shown to [[Protein-protein interaction|interact]] with [[Zif268]].<ref name=pmid7624335 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Russo MW, Sevetson BR, Milbrandt J |title=Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 15 |pages= 6873-7 |year= 1995 |pmid= 7624335 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Svaren J, Sevetson BR, Apel ED, ''et al.'' |title=NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. |journal=Mol. Cell. Biol. |volume=16 |issue= 7 |pages= 3545-53 |year= 1996 |pmid= 8668170 |doi=  }}
*{{cite journal   |vauthors=Thiel G, Kaufmann K, Magin A, etal |title=The human transcriptional repressor protein NAB1: expression and biological activity. |journal=Biochim. Biophys. Acta |volume=1493 |issue= 3 |pages= 289–301 |year= 2000 |pmid= 11018254 |doi=  10.1016/s0167-4781(00)00207-4}}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Qiu FH, Devchand PR, Wada K, Serhan CN |title=Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. |journal=FASEB J. |volume=15 |issue= 14 |pages= 2736–8 |year= 2002 |pmid= 11687510 |doi= 10.1096/fj.01-0576fje }}
*{{cite journal  | author=Swirnoff AH, Apel ED, Svaren J, ''et al.'' |title=Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 512-24 |year= 1998 |pmid= 9418898 |doi= }}
*{{cite journal   |vauthors=Venken K, Di Maria E, Bellone E, etal |title=Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. |journal=Neurogenetics |volume=4 |issue= 1 |pages= 37–41 |year= 2003 |pmid= 12030330 |doi=10.1007/s10048-001-0124-2 }}
*{{cite journal | author=Thiel G, Kaufmann K, Magin A, ''et al.'' |title=The human transcriptional repressor protein NAB1: expression and biological activity. |journal=Biochim. Biophys. Acta |volume=1493 |issue= 3 |pages= 289-301 |year= 2000 |pmid= 11018254 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Qiu FH, Devchand PR, Wada K, Serhan CN |title=Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. |journal=FASEB J. |volume=15 |issue= 14 |pages= 2736-8 |year= 2002 |pmid= 11687510 |doi= 10.1096/fj.01-0576fje }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Venken K, Di Maria E, Bellone E, ''et al.'' |title=Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. |journal=Neurogenetics |volume=4 |issue= 1 |pages= 37-41 |year= 2003 |pmid= 12030330 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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[[Category:Human proteins]]
 
 
{{gene-2-stub}}

Latest revision as of 12:24, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

NGFI-A-binding protein 1 is a protein that in humans is encoded by the NAB1 gene.[1][2][3][4]


Interactions

NAB1 has been shown to interact with Zif268.[1]

References

  1. ↑ 1.0 1.1 Russo MW, Sevetson BR, Milbrandt J (Aug 1995). "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription". Proc Natl Acad Sci U S A. 92 (15): 6873–7. doi:10.1073/pnas.92.15.6873. PMC 41432. PMID 7624335.
  2. ↑ Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. PMC 231349. PMID 8668170.
  3. ↑ Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J (Jan 1998). "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain". Mol Cell Biol. 18 (1): 512–24. PMC 115883. PMID 9418898.
  4. ↑ "Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)".

Further reading


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