ANAPC1: Difference between revisions

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{{Infobox_gene}}
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'''Anaphase-promoting complex subunit 1''' is an [[enzyme]] that in humans is encoded by the ''ANAPC1'' [[gene]].<ref name="pmid11179667">{{cite journal | vauthors = Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C | title = Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex | journal = Gene | volume = 262 | issue = 1-2 | pages = 51–9 |date=February 2001 | pmid = 11179667 | pmc =  | doi =10.1016/S0378-1119(00)00511-4  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ANAPC1 anaphase promoting complex subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64682| accessdate = }}</ref>
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ANAPC1 is one of at least ten subunits of the [[anaphase-promoting complex]] (APC), which functions at the [[metaphase]]-to-[[anaphase]] transition of the [[cell cycle]] and is regulated by [[spindle checkpoint]] proteins. The APC is an [[E3 ubiquitin ligase]] that targets cell cycle regulatory proteins for degradation by the [[proteasome]], thereby allowing progression through the cell cycle (supplied by [[OMIM]]).<ref name="entrez"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Anaphase promoting complex subunit 1
| HGNCid = 19988
| Symbol = ANAPC1
| AltSymbols =; APC1; MCPR; TSG24
| OMIM = 608473
| ECnumber = 
| Homologene = 7414
| MGIid = 103097
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64682
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001129602
    | Hs_RefseqmRNA = XM_001129602
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 17222
    | Mm_Ensembl = ENSMUSG00000014355
    | Mm_RefseqmRNA = NM_008569
    | Mm_RefseqProtein = NP_032595
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 128301549
    | Mm_GenLoc_end = 128378816
    | Mm_Uniprot = Q3TP10
  }}
}}
'''Anaphase promoting complex subunit 1''', also known as '''ANAPC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ANAPC1 anaphase promoting complex subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64682| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
ANAPC1 has been shown to [[Protein-protein interaction|interact]] with [[ANAPC5]],<ref name=pmid12956947>{{cite journal |doi=10.1016/S0960-9822(03)00581-5 |last=Vodermaier |first=Hartmut C |last2=Gieffers |first2=Christian |last3=Maurer-Stroh |first3=Sebastian |last4=Eisenhaber |first4=Frank |last5=Peters |first5=Jan-Michael |date=September 2003  |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 |journal=Curr. Biol. |volume=13 |issue=17 |pages=1459–68 |publisher= |location = England| issn = 0960-9822| pmid = 12956947 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11076961>{{cite journal |doi=10.1083/jcb.151.4.749 |last=Sumara |first=I |author2=Vorlaufer E |author3=Gieffers C |author4=Peters B H |author5=Peters J M  |date=November 2000  |title=Characterization of vertebrate cohesin complexes and their regulation in prophase |journal=J. Cell Biol. |volume=151 |issue=4 |pages=749–62 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 11076961 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2169443 }}</ref> [[ANAPC4]],<ref name=pmid12956947/><ref name=pmid11076961/> [[ANAPC2]],<ref name=pmid12956947/><ref name=pmid11076961/> [[CDC27]]<ref name=pmid12956947/><ref name=pmid11076961/> and [[ANAPC7]].<ref name=pmid12956947/><ref name=pmid11076961/>
| section_title =  
| summary_text = ANAPC1 is 1 of at least 10 subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: ANAPC1 anaphase promoting complex subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64682| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ANAPC1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Grossberger R, Gieffers C, Zachariae W, ''et al.'' |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500-7 |year= 1999 |pmid= 10318877 |doi=  }}
*{{cite journal  | vauthors=Grossberger R, Gieffers C, Zachariae W |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500–7 |year= 1999 |pmid= 10318877 |doi=10.1074/jbc.274.20.14500 |display-authors=etal}}
*{{cite journal  | author=Gieffers C, Peters BH, Kramer ER, ''et al.'' |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317-22 |year= 1999 |pmid= 10500174 |doi=  }}
*{{cite journal  | vauthors=Gieffers C, Peters BH, Kramer ER |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317–22 |year= 1999 |pmid= 10500174 |doi=10.1073/pnas.96.20.11317  | pmc=18031 |display-authors=etal}}
*{{cite journal  | author=Gmachl M, Gieffers C, Podtelejnikov AV, ''et al.'' |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973-8 |year= 2000 |pmid= 10922056 |doi=  }}
*{{cite journal  | vauthors=Gmachl M, Gieffers C, Podtelejnikov AV |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973–8 |year= 2000 |pmid= 10922056 |doi=10.1073/pnas.97.16.8973  | pmc=16806 |display-authors=etal}}
*{{cite journal  | author=Zur A, Brandeis M |title=Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. |journal=EMBO J. |volume=20 |issue= 4 |pages= 792-801 |year= 2001 |pmid= 11179223 |doi= 10.1093/emboj/20.4.792 }}
*{{cite journal  | vauthors=Zur A, Brandeis M |title=Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. |journal=EMBO J. |volume=20 |issue= 4 |pages= 792–801 |year= 2001 |pmid= 11179223 |doi= 10.1093/emboj/20.4.792  | pmc=145417 }}
*{{cite journal | author=Jörgensen PM, Gräslund S, Betz R, ''et al.'' |title=Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. |journal=Gene |volume=262 |issue= 1-2 |pages= 51-9 |year= 2001 |pmid= 11179667 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Vodermaier HC, Gieffers C, Maurer-Stroh S |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459–68 |year= 2004 |pmid= 12956947 |doi=10.1016/S0960-9822(03)00581-5 |display-authors=etal}}
*{{cite journal  | author=Vodermaier HC, Gieffers C, Maurer-Stroh S, ''et al.'' |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459-68 |year= 2004 |pmid= 12956947 |doi=  }}
*{{cite journal  | vauthors=Kraft C, Herzog F, Gieffers C |title=Mitotic regulation of the human anaphase-promoting complex by phosphorylation. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6598–609 |year= 2004 |pmid= 14657031 |doi= 10.1093/emboj/cdg627 | pmc=291822 |display-authors=etal}}
*{{cite journal  | author=Kraft C, Herzog F, Gieffers C, ''et al.'' |title=Mitotic regulation of the human anaphase-promoting complex by phosphorylation. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6598-609 |year= 2004 |pmid= 14657031 |doi= 10.1093/emboj/cdg627 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Nousiainen M, Silljé HH, Sauer G |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |display-authors=etal}}
*{{cite journal  | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
}}
}}
{{refend}}
{{refend}}
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Revision as of 18:00, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.[1][2]

ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM).[2]

Interactions

ANAPC1 has been shown to interact with ANAPC5,[3][4] ANAPC4,[3][4] ANAPC2,[3][4] CDC27[3][4] and ANAPC7.[3][4]

References

  1. ↑ Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1–2): 51–9. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667.
  2. ↑ 2.0 2.1 "Entrez Gene: ANAPC1 anaphase promoting complex subunit 1".
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. UNITED STATES. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.

External links

Further reading



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