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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Signal transducing adapter molecule 2''' is a [[protein]] that in humans is encoded by the ''STAM2'' [[gene]].<ref name="pmid10899310">{{cite journal | vauthors = Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K | title = STAM2, a new member of the STAM family, binding to the Janus kinases | journal = FEBS Letters | volume = 477 | issue = 1-2 | pages = 55–61 | date = Jul 2000 | pmid = 10899310 | pmc =  | doi = 10.1016/S0014-5793(00)01760-9 }}</ref><ref name="pmid10993906">{{cite journal | vauthors = Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF | title = Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways | journal = The Journal of Biological Chemistry | volume = 275 | issue = 49 | pages = 38633–9 | date = Dec 2000 | pmid = 10993906 | pmc = | doi = 10.1074/jbc.M007849200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10254| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_STAM2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1x2q.
| PDB = {{PDB2|1x2q}}, {{PDB2|1x5b}}
| Name = Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
| HGNCid = 11358
| Symbol = STAM2
| AltSymbols =; DKFZp564C047; Hbp; STAM2A; STAM2B
| OMIM = 606244
| ECnumber = 
| Homologene = 68490
| MGIid = 1929100
| GeneAtlas_image1 = PBB_GE_STAM2_209649_at_tn.png
| GeneAtlas_image2 = PBB_GE_STAM2_208194_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_STAM2_215044_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10254
    | Hs_Ensembl = ENSG00000115145
    | Hs_RefseqProtein = NP_005834
    | Hs_RefseqmRNA = NM_005843
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 152683353
    | Hs_GenLoc_end = 152740752
    | Hs_Uniprot = O75886
    | Mm_EntrezGene = 56324
    | Mm_Ensembl = ENSMUSG00000055371
    | Mm_RefseqmRNA = NM_019667
    | Mm_RefseqProtein = NP_062641
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 52513673
    | Mm_GenLoc_end = 52564209
    | Mm_Uniprot = Q3TGH8
  }}
}}
'''Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2''', also known as '''STAM2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10254| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.<ref name="entrez">{{cite web | title = Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10254| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
STAM2 has been shown to [[Protein-protein interaction|interact]] with [[HGS (gene)|HGS]],<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid12551915>{{cite journal | vauthors = Bache KG, Raiborg C, Mehlum A, Stenmark H | title = STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 14 | pages = 12513–21 | date = Apr 2003 | pmid = 12551915 | doi = 10.1074/jbc.M210843200 }}</ref> [[Janus kinase 1]]<ref name=pmid10899310 /><ref name=pmid10993906 /> and [[USP8]].<ref name=pmid13129930>{{cite journal | vauthors = Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N | title = Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 48 | pages = 48162–8 | date = Nov 2003 | pmid = 13129930 | doi = 10.1074/jbc.M306677200 }}</ref><ref name=pmid10982817>{{cite journal | vauthors = Kato M, Miyazawa K, Kitamura N | title = A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal = The Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37481–7 | date = Dec 2000 | pmid = 10982817 | doi = 10.1074/jbc.M007251200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Sulman EP, Tang XX, Allen C, Biegel JA, Pleasure DE, Brodeur GM, Ikegaki N | title = ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers | journal = Genomics | volume = 40 | issue = 2 | pages = 371–4 | date = Mar 1997 | pmid = 9119409 | doi = 10.1006/geno.1996.4569 }}
| citations =
* {{cite journal | vauthors = Kato M, Miyazawa K, Kitamura N | title = A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal = The Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37481–7 | date = Dec 2000 | pmid = 10982817 | doi = 10.1074/jbc.M007251200 }}
*{{cite journal | author=Sulman EP, Tang XX, Allen C, ''et al.'' |title=ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. |journal=Genomics |volume=40 |issue= 2 |pages= 371-4 |year= 1997 |pmid= 9119409 |doi= 10.1006/geno.1996.4569 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Endo K, Takeshita T, Kasai H, ''et al.'' |title=STAM2, a new member of the STAM family, binding to the Janus kinases. |journal=FEBS Lett. |volume=477 |issue= 1-2 |pages= 55-61 |year= 2000 |pmid= 10899310 |doi=  }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal  | author=Kato M, Miyazawa K, Kitamura N |title=A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37481-7 |year= 2001 |pmid= 10982817 |doi= 10.1074/jbc.M007251200 }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Pandey A, Fernandez MM, Steen H, ''et al.'' |title=Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38633-9 |year= 2001 |pmid= 10993906 |doi= 10.1074/jbc.M007849200 }}
* {{cite journal | vauthors = Steen H, Kuster B, Fernandez M, Pandey A, Mann M | title = Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway | journal = The Journal of Biological Chemistry | volume = 277 | issue = 2 | pages = 1031–9 | date = Jan 2002 | pmid = 11687594 | doi = 10.1074/jbc.M109992200 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Bache KG, Raiborg C, Mehlum A, Stenmark H | title = STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 14 | pages = 12513–21 | date = Apr 2003 | pmid = 12551915 | doi = 10.1074/jbc.M210843200 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N | title = Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 48 | pages = 48162–8 | date = Nov 2003 | pmid = 13129930 | doi = 10.1074/jbc.M306677200 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Mizuno E, Kawahata K, Okamoto A, Kitamura N, Komada M | title = Association with Hrs is required for the early endosomal localization, stability, and function of STAM | journal = Journal of Biochemistry | volume = 135 | issue = 3 | pages = 385–96 | date = Mar 2004 | pmid = 15113837 | doi = 10.1093/jb/mvh046 }}
*{{cite journal | author=Steen H, Kuster B, Fernandez M, ''et al.'' |title=Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1031-9 |year= 2002 |pmid= 11687594 |doi= 10.1074/jbc.M109992200 }}
* {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–72 | date = May 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
*{{cite journal  | author=Bache KG, Raiborg C, Mehlum A, Stenmark H |title=STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 12513-21 |year= 2003 |pmid= 12551915 |doi= 10.1074/jbc.M210843200 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Kaneko T, Kumasaka T, Ganbe T, ''et al.'' |title=Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 48162-8 |year= 2004 |pmid= 13129930 |doi= 10.1074/jbc.M306677200 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Lechner MS, Schultz DC, Negorev D, Maul GG, Rauscher FJ | title = The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain | journal = Biochemical and Biophysical Research Communications | volume = 331 | issue = 4 | pages = 929–37 | date = Jun 2005 | pmid = 15882967 | doi = 10.1016/j.bbrc.2005.04.016 }}
*{{cite journal  | author=Mizuno E, Kawahata K, Okamoto A, ''et al.'' |title=Association with Hrs is required for the early endosomal localization, stability, and function of STAM. |journal=J. Biochem. |volume=135 |issue= 3 |pages= 385-96 |year= 2005 |pmid= 15113837 |doi= }}
*{{cite journal | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Lechner MS, Schultz DC, Negorev D, ''et al.'' |title=The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 4 |pages= 929-37 |year= 2005 |pmid= 15882967 |doi= 10.1016/j.bbrc.2005.04.016 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|STAM2}}
* {{UCSC gene details|STAM2}}
 
{{PDB Gallery|geneid=10254}}
 
 
{{gene-2-stub}}

Latest revision as of 07:09, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene.[1][2][3]

Function

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.[3]

Interactions

STAM2 has been shown to interact with HGS,[4][5] Janus kinase 1[1][2] and USP8.[6][7]

References

  1. ↑ Jump up to: 1.0 1.1 Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K (Jul 2000). "STAM2, a new member of the STAM family, binding to the Janus kinases". FEBS Letters. 477 (1–2): 55–61. doi:10.1016/S0014-5793(00)01760-9. PMID 10899310.
  2. ↑ Jump up to: 2.0 2.1 Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF (Dec 2000). "Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways". The Journal of Biological Chemistry. 275 (49): 38633–9. doi:10.1074/jbc.M007849200. PMID 10993906.
  3. ↑ Jump up to: 3.0 3.1 "Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2".
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  5. ↑ Bache KG, Raiborg C, Mehlum A, Stenmark H (Apr 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". The Journal of Biological Chemistry. 278 (14): 12513–21. doi:10.1074/jbc.M210843200. PMID 12551915.
  6. ↑ Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (Nov 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930.
  7. ↑ Kato M, Miyazawa K, Kitamura N (Dec 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=STAM2&oldid=1412132"