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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zona pellucida sperm-binding protein 4''', '''ZP-4''' or '''avilesine''', named after its discoverer [[Manuel Avilés Sánchez]]<ref name="pmid25623231">{{cite journal | authors = Avilés M, Moros C, García-Vázquez FA, Gimeno L, Torrecillas A, Aliaga C, Bernardo-Pisa MV, Ballesta J, Izquierdo-Rico MJ. | title = Four glycoproteins are expressed in the cat zona pellucida | journal = Theriogenology | volume = 83 | issue = 7 | pages = 1162-73 | date = April 2015 | pmid = 25623231 | pmc =  | doi = 10.1016/j.theriogenology.2014.12.019 }}</ref>is a [[protein]] that in humans is encoded by the ''ZP4'' [[gene]].<ref name="pmid7841460">{{cite journal | vauthors = Harris JD, Hibler DW, Fontenot GK, Hsu KT, Yurewicz EC, Sacco AG | title = Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families | journal = DNA Sequence | volume = 4 | issue = 6 | pages = 361–93 | date = Mar 1995 | pmid = 7841460 | pmc = | doi = 10.3109/10425179409010186 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZP4 zona pellucida glycoprotein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57829| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Zona pellucida glycoprotein 4
| HGNCid = 15770
| Symbol = ZP4
| AltSymbols =; ZP1; ZBP; ZPB
| OMIM = 
| ECnumber = 
| Homologene = 49661
| MGIid = 
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0032190 |text = acrosin binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007338 |text = single fertilization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57829
    | Hs_Ensembl = ENSG00000116996
    | Hs_RefseqProtein = NP_067009
    | Hs_RefseqmRNA = NM_021186
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 236112328
    | Hs_GenLoc_end = 236120717
    | Hs_Uniprot = Q12836
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Zona pellucida glycoprotein 4''', also known as '''ZP4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZP4 zona pellucida glycoprotein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57829| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[zona pellucida]] is an [[extracellular matrix]] that surrounds the [[oocyte]] and early [[embryo]]. It is composed primarily of three or four [[glycoprotein]]s with various functions during fertilization and preimplantation development. The nascent protein contains a [[N-terminus|N-terminal]] [[signal peptide]] sequence, a conserved [[zona pellucida-like domain]], a consensus [[furin]] cleavage site, and a [[C-terminus|C-terminal]] transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.
{{PBB_Summary
| section_title =
| summary_text = The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4.<ref name="entrez">{{cite web | title = Entrez Gene: ZP4 zona pellucida glycoprotein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57829| accessdate = }}</ref>
}}


==References==
Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1.<ref name="pmid15760956">{{cite journal | vauthors = Conner SJ, Lefièvre L, Hughes DC, Barratt CL | title = Cracking the egg: increased complexity in the zona pellucida | journal = Human Reproduction | volume = 20 | issue = 5 | pages = 1148–52 | date = May 2005 | pmid = 15760956 | doi = 10.1093/humrep/deh835 }}</ref> However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4.<ref name="entrez"/>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rankin T, Dean J | title = The zona pellucida: using molecular genetics to study the mammalian egg coat | journal = Reviews of Reproduction | volume = 5 | issue = 2 | pages = 114–21 | date = May 2000 | pmid = 10864856 | doi = 10.1530/ror.0.0050114 }}
| citations =
* {{cite journal | vauthors = Eberspaecher U, Becker A, Bringmann P, van der Merwe L, Donner P | title = Immunohistochemical localization of zona pellucida proteins ZPA, ZPB and ZPC in human, cynomolgus monkey and mouse ovaries | journal = Cell and Tissue Research | volume = 303 | issue = 2 | pages = 277–87 | date = Feb 2001 | pmid = 11291774 | doi = 10.1007/s004410000287 }}
*{{cite journal | author=Rankin T, Dean J |title=The zona pellucida: using molecular genetics to study the mammalian egg coat. |journal=Rev. Reprod. |volume=5 |issue= 2 |pages= 114-21 |year= 2000 |pmid= 10864856 |doi= }}
* {{cite journal | vauthors = Kiefer SM, Saling P | title = Proteolytic processing of human zona pellucida proteins | journal = Biology of Reproduction | volume = 66 | issue = 2 | pages = 407–14 | date = Feb 2002 | pmid = 11804956 | doi = 10.1095/biolreprod66.2.407 }}
*{{cite journal  | author=Harris JD, Hibler DW, Fontenot GK, ''et al.'' |title=Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. |journal=DNA Seq. |volume=4 |issue= 6 |pages= 361-93 |year= 1995 |pmid= 7841460 |doi=  }}
* {{cite journal | vauthors = Qi H, Williams Z, Wassarman PM | title = Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3 | journal = Molecular Biology of the Cell | volume = 13 | issue = 2 | pages = 530–41 | date = Feb 2002 | pmid = 11854410 | pmc = 65647 | doi = 10.1091/mbc.01-09-0440 }}
*{{cite journal | author=Eberspaecher U, Becker A, Bringmann P, ''et al.'' |title=Immunohistochemical localization of zona pellucida proteins ZPA, ZPB and ZPC in human, cynomolgus monkey and mouse ovaries. |journal=Cell Tissue Res. |volume=303 |issue= 2 |pages= 277-87 |year= 2001 |pmid= 11291774 |doi= }}
* {{cite journal | vauthors = Zhao M, Gold L, Ginsberg AM, Liang LF, Dean J | title = Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice | journal = Molecular and Cellular Biology | volume = 22 | issue = 9 | pages = 3111–20 | date = May 2002 | pmid = 11940668 | pmc = 133755 | doi = 10.1128/MCB.22.9.3111-3120.2002 }}
*{{cite journal | author=Kiefer SM, Saling P |title=Proteolytic processing of human zona pellucida proteins. |journal=Biol. Reprod. |volume=66 |issue= 2 |pages= 407-14 |year= 2002 |pmid= 11804956 |doi= }}
* {{cite journal | vauthors = Lefièvre L, Conner SJ, Salpekar A, Olufowobi O, Ashton P, Pavlovic B, Lenton W, Afnan M, Brewis IA, Monk M, Hughes DC, Barratt CL | title = Four zona pellucida glycoproteins are expressed in the human | journal = Human Reproduction | volume = 19 | issue = 7 | pages = 1580–6 | date = Jul 2004 | pmid = 15142998 | doi = 10.1093/humrep/deh301 }}
*{{cite journal | author=Qi H, Williams Z, Wassarman PM |title=Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3. |journal=Mol. Biol. Cell |volume=13 |issue= 2 |pages= 530-41 |year= 2002 |pmid= 11854410 |doi= 10.1091/mbc.01-09-0440 }}
* {{cite journal | vauthors = Chakravarty S, Suraj K, Gupta SK | title = Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C | journal = Molecular Human Reproduction | volume = 11 | issue = 5 | pages = 365–72 | date = May 2005 | pmid = 15805145 | doi = 10.1093/molehr/gah165 }}
*{{cite journal | author=Zhao M, Gold L, Ginsberg AM, ''et al.'' |title=Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 3111-20 |year= 2002 |pmid= 11940668 |doi= }}
* {{cite journal | vauthors = Furlong LI, Harris JD, Vazquez-Levin MH | title = Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC | journal = Fertility and Sterility | volume = 83 | issue = 6 | pages = 1780–90 | date = Jun 2005 | pmid = 15950651 | doi = 10.1016/j.fertnstert.2004.12.042 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Caballero-Campo P, Chirinos M, Fan XJ, González-González ME, Galicia-Chavarría M, Larrea F, Gerton GL | title = Biological effects of recombinant human zona pellucida proteins on sperm function | journal = Biology of Reproduction | volume = 74 | issue = 4 | pages = 760–8 | date = Apr 2006 | pmid = 16407501 | doi = 10.1095/biolreprod.105.047522 }}
*{{cite journal | author=Lefièvre L, Conner SJ, Salpekar A, ''et al.'' |title=Four zona pellucida glycoproteins are expressed in the human. |journal=Hum. Reprod. |volume=19 |issue= 7 |pages= 1580-6 |year= 2005 |pmid= 15142998 |doi= 10.1093/humrep/deh301 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Chakravarty S, Suraj K, Gupta SK |title=Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C. |journal=Mol. Hum. Reprod. |volume=11 |issue= 5 |pages= 365-72 |year= 2005 |pmid= 15805145 |doi= 10.1093/molehr/gah165 }}
*{{cite journal | author=Furlong LI, Harris JD, Vazquez-Levin MH |title=Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. |journal=Fertil. Steril. |volume=83 |issue= 6 |pages= 1780-90 |year= 2006 |pmid= 15950651 |doi= 10.1016/j.fertnstert.2004.12.042 }}
*{{cite journal | author=Caballero-Campo P, Chirinos M, Fan XJ, ''et al.'' |title=Biological effects of recombinant human zona pellucida proteins on sperm function. |journal=Biol. Reprod. |volume=74 |issue= 4 |pages= 760-8 |year= 2006 |pmid= 16407501 |doi= 10.1095/biolreprod.105.047522 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


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Revision as of 07:24, 16 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zona pellucida sperm-binding protein 4, ZP-4 or avilesine, named after its discoverer Manuel Avilés Sánchez[1]is a protein that in humans is encoded by the ZP4 gene.[2][3]

Function

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved zona pellucida-like domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.

Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1.[4] However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4.[3]

References

  1. ↑ Avilés M, Moros C, García-Vázquez FA, Gimeno L, Torrecillas A, Aliaga C, Bernardo-Pisa MV, Ballesta J, Izquierdo-Rico MJ. (April 2015). "Four glycoproteins are expressed in the cat zona pellucida". Theriogenology. 83 (7): 1162–73. doi:10.1016/j.theriogenology.2014.12.019. PMID 25623231.
  2. ↑ Harris JD, Hibler DW, Fontenot GK, Hsu KT, Yurewicz EC, Sacco AG (Mar 1995). "Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families". DNA Sequence. 4 (6): 361–93. doi:10.3109/10425179409010186. PMID 7841460.
  3. ↑ 3.0 3.1 "Entrez Gene: ZP4 zona pellucida glycoprotein 4".
  4. ↑ Conner SJ, Lefièvre L, Hughes DC, Barratt CL (May 2005). "Cracking the egg: increased complexity in the zona pellucida". Human Reproduction. 20 (5): 1148–52. doi:10.1093/humrep/deh835. PMID 15760956.

Further reading


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