STX6: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Syntaxin-6''' is a [[protein]] that in humans is encoded by the ''STX6'' [[gene]].<ref name="pmid10080545">{{cite journal | vauthors = Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F | title = Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1 | journal = Journal of Leukocyte Biology | volume = 65 | issue = 3 | pages = 397–406 | date = Mar 1999 | pmid = 10080545 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STX6 syntaxin 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10228| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_STX6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lvf.
| PDB = {{PDB2|1lvf}}, {{PDB2|2nps}}
| Name = Syntaxin 6
| HGNCid = 11441
| Symbol = STX6
| AltSymbols =;
| OMIM = 603944
| ECnumber = 
| Homologene = 21184
| MGIid = 1926235
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008565 |text = protein transporter activity}}
| Component = {{GNF_GO|id=GO:0005769 |text = early endosome}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0030136 |text = clathrin-coated vesicle}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006906 |text = vesicle fusion}} {{GNF_GO|id=GO:0007032 |text = endosome organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10228
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_005810
    | Hs_RefseqmRNA = NM_005819
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 58244
    | Mm_Ensembl = ENSMUSG00000026470
    | Mm_RefseqmRNA = NM_021433
    | Mm_RefseqProtein = NP_067408
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 156920960
    | Mm_GenLoc_end = 156965735
    | Mm_Uniprot = Q3TR14
  }}
}}
'''Syntaxin 6''', also known as '''STX6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STX6 syntaxin 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10228| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
STX6 has been shown to [[Protein-protein interaction|interact]] with [[SNAP23]],<ref name=pmid11001914>{{cite journal | vauthors = Martín-Martín B, Nabokina SM, Blasi J, Lazo PA, Mollinedo F | title = Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis | journal = Blood | volume = 96 | issue = 7 | pages = 2574–83 | date = Oct 2000 | pmid = 11001914 }}</ref> [[VAMP3]]<ref name=pmid11839770>{{cite journal | vauthors = Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L | title = Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform | journal = The Journal of Cell Biology | volume = 156 | issue = 4 | pages = 653–64 | date = Feb 2002 | pmid = 11839770 | pmc = 2174079 | doi = 10.1083/jcb.200110081 }}</ref> and [[VAMP4]].<ref name=pmid11839770/>
{{PBB_Summary
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| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = Apr 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
| citations =
* {{cite journal | vauthors = Bock JB, Lin RC, Scheller RH | title = A new syntaxin family member implicated in targeting of intracellular transport vesicles | journal = The Journal of Biological Chemistry | volume = 271 | issue = 30 | pages = 17961–5 | date = Jul 1996 | pmid = 8663448 | doi = 10.1074/jbc.271.30.17961 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Bock JB, Lin RC, Scheller RH |title=A new syntaxin family member implicated in targeting of intracellular transport vesicles. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 17961-5 |year= 1996 |pmid= 8663448 |doi= }}
* {{cite journal | vauthors = Simonsen A, Lippé R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H | title = EEA1 links PI(3)K function to Rab5 regulation of endosome fusion | journal = Nature | volume = 394 | issue = 6692 | pages = 494–8 | date = Jul 1998 | pmid = 9697774 | doi = 10.1038/28879 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Wong SH, Xu Y, Zhang T, Griffiths G, Lowe SL, Subramaniam VN, Seow KT, Hong W | title = GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6 | journal = Molecular Biology of the Cell | volume = 10 | issue = 1 | pages = 119–34 | date = Jan 1999 | pmid = 9880331 | pmc = 25158 | doi = 10.1091/mbc.10.1.119 }}
*{{cite journal | author=Simonsen A, Lippé R, Christoforidis S, ''et al.'' |title=EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. |journal=Nature |volume=394 |issue= 6692 |pages= 494-8 |year= 1998 |pmid= 9697774 |doi= 10.1038/28879 }}
* {{cite journal | vauthors = Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH | title = Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking | journal = Molecular Biology of the Cell | volume = 10 | issue = 6 | pages = 1957–72 | date = Jun 1999 | pmid = 10359608 | pmc = 25394 | doi = 10.1091/mbc.10.6.1957 }}
*{{cite journal | author=Wong SH, Xu Y, Zhang T, ''et al.'' |title=GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6. |journal=Mol. Biol. Cell |volume=10 |issue= 1 |pages= 119-34 |year= 1999 |pmid= 9880331 |doi= }}
* {{cite journal | vauthors = Simonsen A, Gaullier JM, D'Arrigo A, Stenmark H | title = The Rab5 effector EEA1 interacts directly with syntaxin-6 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 41 | pages = 28857–60 | date = Oct 1999 | pmid = 10506127 | doi = 10.1074/jbc.274.41.28857 }}
*{{cite journal  | author=Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F |title=Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. |journal=J. Leukoc. Biol. |volume=65 |issue= 3 |pages= 397-406 |year= 1999 |pmid= 10080545 |doi=  }}
* {{cite journal | vauthors = Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH | title = SNAREs contribute to the specificity of membrane fusion | journal = Neuron | volume = 26 | issue = 2 | pages = 457–64 | date = May 2000 | pmid = 10839363 | doi = 10.1016/S0896-6273(00)81177-0 }}
*{{cite journal | author=Steegmaier M, Klumperman J, Foletti DL, ''et al.'' |title=Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking. |journal=Mol. Biol. Cell |volume=10 |issue= 6 |pages= 1957-72 |year= 1999 |pmid= 10359608 |doi= }}
* {{cite journal | vauthors = Martín-Martín B, Nabokina SM, Blasi J, Lazo PA, Mollinedo F | title = Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis | journal = Blood | volume = 96 | issue = 7 | pages = 2574–83 | date = Oct 2000 | pmid = 11001914 | doi =  }}
*{{cite journal | author=Simonsen A, Gaullier JM, D'Arrigo A, Stenmark H |title=The Rab5 effector EEA1 interacts directly with syntaxin-6. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 28857-60 |year= 1999 |pmid= 10506127 |doi= }}
* {{cite journal | vauthors = Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE | title = Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 23 | pages = 19820–7 | date = Jun 2001 | pmid = 11278762 | doi = 10.1074/jbc.M010838200 }}
*{{cite journal | author=Scales SJ, Chen YA, Yoo BY, ''et al.'' |title=SNAREs contribute to the specificity of membrane fusion. |journal=Neuron |volume=26 |issue= 2 |pages= 457-64 |year= 2000 |pmid= 10839363 |doi= }}
* {{cite journal | vauthors = Charest A, Lane K, McMahon K, Housman DE | title = Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29456–65 | date = Aug 2001 | pmid = 11384996 | doi = 10.1074/jbc.M104137200 }}
*{{cite journal | author=Martín-Martín B, Nabokina SM, Blasi J, ''et al.'' |title=Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis. |journal=Blood |volume=96 |issue= 7 |pages= 2574-83 |year= 2000 |pmid= 11001914 |doi=  }}
* {{cite journal | vauthors = Rotem-Yehudar R, Galperin E, Horowitz M | title = Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 33054–60 | date = Aug 2001 | pmid = 11423532 | doi = 10.1074/jbc.M009913200 }}
*{{cite journal | author=Wade N, Bryant NJ, Connolly LM, ''et al.'' |title=Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 19820-7 |year= 2001 |pmid= 11278762 |doi= 10.1074/jbc.M010838200 }}
* {{cite journal | vauthors = Cheng J, Moyer BD, Milewski M, Loffing J, Ikeda M, Mickle JE, Cutting GR, Li M, Stanton BA, Guggino WB | title = A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3520–9 | date = Feb 2002 | pmid = 11707463 | doi = 10.1074/jbc.M110177200 }}
*{{cite journal | author=Charest A, Lane K, McMahon K, Housman DE |title=Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29456-65 |year= 2001 |pmid= 11384996 |doi= 10.1074/jbc.M104137200 }}
* {{cite journal | vauthors = Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L | title = Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform | journal = The Journal of Cell Biology | volume = 156 | issue = 4 | pages = 653–64 | date = Feb 2002 | pmid = 11839770 | pmc = 2174079 | doi = 10.1083/jcb.200110081 }}
*{{cite journal | author=Rotem-Yehudar R, Galperin E, Horowitz M |title=Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33054-60 |year= 2001 |pmid= 11423532 |doi= 10.1074/jbc.M009913200 }}
* {{cite journal | vauthors = Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T | title = A dual mechanism controlling the localization and function of exocytic v-SNAREs | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 15 | pages = 9011–6 | date = Jul 2003 | pmid = 12853575 | pmc = 166429 | doi = 10.1073/pnas.1431910100 }}
*{{cite journal | author=Cheng J, Moyer BD, Milewski M, ''et al.'' |title=A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3520-9 |year= 2002 |pmid= 11707463 |doi= 10.1074/jbc.M110177200 }}
* {{cite journal | vauthors = Kim BY, Ueda M, Kominami E, Akagawa K, Kohsaka S, Akazawa C | title = Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex | journal = Biochemical and Biophysical Research Communications | volume = 311 | issue = 3 | pages = 577–82 | date = Nov 2003 | pmid = 14623309 | doi = 10.1016/j.bbrc.2003.10.030 }}
*{{cite journal | author=Mallard F, Tang BL, Galli T, ''et al.'' |title=Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. |journal=J. Cell Biol. |volume=156 |issue= 4 |pages= 653-64 |year= 2002 |pmid= 11839770 |doi= 10.1083/jcb.200110081 }}
* {{cite journal | vauthors = Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T | title = Control of vesicle fusion by a tyrosine phosphatase | journal = Nature Cell Biology | volume = 6 | issue = 9 | pages = 831–9 | date = Sep 2004 | pmid = 15322554 | doi = 10.1038/ncb1164 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Martinez-Arca S, Rudge R, Vacca M, ''et al.'' |title=A dual mechanism controlling the localization and function of exocytic v-SNAREs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 9011-6 |year= 2003 |pmid= 12853575 |doi= 10.1073/pnas.1431910100 }}
*{{cite journal | author=Kim BY, Ueda M, Kominami E, ''et al.'' |title=Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 3 |pages= 577-82 |year= 2004 |pmid= 14623309 |doi= }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Huynh H, Bottini N, Williams S, ''et al.'' |title=Control of vesicle fusion by a tyrosine phosphatase. |journal=Nat. Cell Biol. |volume=6 |issue= 9 |pages= 831-9 |year= 2004 |pmid= 15322554 |doi= 10.1038/ncb1164 }}
}}
{{refend}}
{{refend}}
== External links ==
* {{UCSC genome browser|STX6}}
* {{UCSC gene details|STX6}}
{{PDB Gallery|geneid=10228}}
{{Vesicular transport proteins}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 07:15, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Syntaxin-6 is a protein that in humans is encoded by the STX6 gene.[1][2]

Interactions

STX6 has been shown to interact with SNAP23,[3] VAMP3[4] and VAMP4.[4]

References

  1. ↑ Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (Mar 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". Journal of Leukocyte Biology. 65 (3): 397–406. PMID 10080545.
  2. ↑ "Entrez Gene: STX6 syntaxin 6".
  3. ↑ Martín-Martín B, Nabokina SM, Blasi J, Lazo PA, Mollinedo F (Oct 2000). "Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis". Blood. 96 (7): 2574–83. PMID 11001914.
  4. ↑ 4.0 4.1 Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

Further reading

External links


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