RFX5: Difference between revisions

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Latest revision as of 09:09, 10 September 2017

DNA-binding protein RFX5 is a protein that in humans is encoded by the RFX5 gene.^[1]^[2]

Function

A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the Xbox of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.^[2]

Interactions

RFX5 has been shown to interact with CIITA.^[3]^[4]

References

↑ Villard J, Reith W, Barras E, Gos A, Morris MA, Antonarakis SE, Van den Elsen PJ, Mach B (January 1998). "Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency". Human Mutation. 10 (6): 430–5. doi:10.1002/(SICI)1098-1004(1997)10:6<430::AID-HUMU3>3.0.CO;2-H. PMID 9401005.
↑ ^2.0 ^2.1 "Entrez Gene: RFX5 regulatory factor X, 5 (influences HLA class II expression)".
↑ Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V (Oct 2000). "CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation". Molecular and Cellular Biology. 20 (20): 7716–25. doi:10.1128/MCB.20.20.7716-7725.2000. PMC 86349. PMID 11003667.
↑ Scholl T, Mahanta SK, Strominger JL (Jun 1997). "Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6330–4. doi:10.1073/pnas.94.12.6330. PMC 21049. PMID 9177217.

Reith W, Mach B (2001). "The bare lymphocyte syndrome and the regulation of MHC expression". Annual Review of Immunology. 19: 331–73. doi:10.1146/annurev.immunol.19.1.331. PMID 11244040.
Steimle V, Durand B, Barras E, Zufferey M, Hadam MR, Mach B, Reith W (May 1995). "A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)". Genes & Development. 9 (9): 1021–32. doi:10.1101/gad.9.9.1021. PMID 7744245.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Durand B, Sperisen P, Emery P, Barras E, Zufferey M, Mach B, Reith W (Mar 1997). "RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency". The EMBO Journal. 16 (5): 1045–55. doi:10.1093/emboj/16.5.1045. PMC 1169704. PMID 9118943.
Scholl T, Mahanta SK, Strominger JL (Jun 1997). "Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6330–4. doi:10.1073/pnas.94.12.6330. PMC 21049. PMID 9177217.
Moreno CS, Rogers EM, Brown JA, Boss JM (Jun 1997). "Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complex". Journal of Immunology. 158 (12): 5841–8. PMID 9190936.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W (Nov 1998). "A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients". Nature Genetics. 20 (3): 273–7. doi:10.1038/3081. PMID 9806546.
Nagarajan UM, Louis-Plence P, DeSandro A, Nilsen R, Bushey A, Boss JM (Feb 1999). "RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency". Immunity. 10 (2): 153–62. doi:10.1016/S1074-7613(00)80016-3. PMID 10072068.
Peijnenburg A, Van Eggermond MC, Van den Berg R, Sanal O, Vossen JM, Van den Elsen PJ (Apr 1999). "Molecular analysis of an MHC class II deficiency patient reveals a novel mutation in the RFX5 gene". Immunogenetics. 49 (4): 338–45. doi:10.1007/s002510050501. PMID 10079298.
Villard J, Peretti M, Masternak K, Barras E, Caretti G, Mantovani R, Reith W (May 2000). "A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y". Molecular and Cellular Biology. 20 (10): 3364–76. doi:10.1128/MCB.20.10.3364-3376.2000. PMC 85629. PMID 10779326.
Nekrep N, Jabrane-Ferrat N, Peterlin BM (Jun 2000). "Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex". Molecular and Cellular Biology. 20 (12): 4455–61. doi:10.1128/MCB.20.12.4455-4461.2000. PMC 85813. PMID 10825209.
Sengupta PK, Fargo J, Smith BD (Jul 2002). "The RFX family interacts at the collagen (COL1A2) start site and represses transcription". The Journal of Biological Chemistry. 277 (28): 24926–37. doi:10.1074/jbc.M111712200. PMID 11986307.
Nekrep N, Jabrane-Ferrat N, Wolf HM, Eibl MM, Geyer M, Peterlin BM (Nov 2002). "Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome". Nature Immunology. 3 (11): 1075–81. doi:10.1038/ni840. PMID 12368908.
Xu Y, Wang L, Buttice G, Sengupta PK, Smith BD (Dec 2003). "Interferon gamma repression of collagen (COL1A2) transcription is mediated by the RFX5 complex". The Journal of Biological Chemistry. 278 (49): 49134–44. doi:10.1074/jbc.M309003200. PMID 12968017.
Nagarajan UM, Long AB, Harreman MT, Corbett AH, Boss JM (Jul 2004). "A hierarchy of nuclear localization signals governs the import of the regulatory factor X complex subunits and MHC class II expression". Journal of Immunology. 173 (1): 410–9. doi:10.4049/jimmunol.173.1.410. PMID 15210800.
Hjerrild M, Stensballe A, Rasmussen TE, Kofoed CB, Blom N, Sicheritz-Ponten T, Larsen MR, Brunak S, Jensen ON, Gammeltoft S (2004). "Identification of phosphorylation sites in protein kinase A substrates using artificial neural networks and mass spectrometry". Journal of Proteome Research. 3 (3): 426–33. doi:10.1021/pr0341033. PMID 15253423.

External links

RFX5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
FactorBook RFX5

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid9401005-1] Villard J, Reith W, Barras E, Gos A, Morris MA, Antonarakis SE, Van den Elsen PJ, Mach B (January 1998). "Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency". Human Mutation. 10 (6): 430–5. doi:10.1002/(SICI)1098-1004(1997)10:6<430::AID-HUMU3>3.0.CO;2-H. PMID 9401005.

[entrez-2] 2.0 ^2.1 "Entrez Gene: RFX5 regulatory factor X, 5 (influences HLA class II expression)".

[pmid11003667-3] Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V (Oct 2000). "CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation". Molecular and Cellular Biology. 20 (20): 7716–25. doi:10.1128/MCB.20.20.7716-7725.2000. PMC 86349. PMID 11003667.

[pmid9177217-4] Scholl T, Mahanta SK, Strominger JL (Jun 1997). "Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6330–4. doi:10.1073/pnas.94.12.6330. PMC 21049. PMID 9177217.

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''DNA-binding protein RFX5''' is a [[protein]] that in humans is encoded by the ''RFX5'' [[gene]].<ref name="pmid9401005">{{cite journal | vauthors = Villard J, Reith W, Barras E, Gos A, Morris MA, Antonarakis SE, Van den Elsen PJ, Mach B | title = Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency | journal = Human Mutation | volume = 10 | issue = 6 | pages = 430–5 | date = January 1998 | pmid = 9401005 | pmc =  | doi = 10.1002/(SICI)1098-1004(1997)10:6<430::AID-HUMU3>3.0.CO;2-H }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RFX5 regulatory factor X, 5 (influences HLA class II expression)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5993| accessdate = }}</ref>
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-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Regulatory factor X, 5 (influences HLA class II expression)
- | HGNCid = 9986
- | Symbol = RFX5
- | AltSymbols =;
- | OMIM = 601863
- | ECnumber =
- | Homologene = 388
- | MGIid = 1858421
- | GeneAtlas_image1 = PBB_GE_RFX5_202963_at_tn.png
- | GeneAtlas_image2 = PBB_GE_RFX5_202964_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5993
-    | Hs_Ensembl = ENSG00000143390
-    | Hs_RefseqProtein = NP_000440
-    | Hs_RefseqmRNA = NM_000449
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 149579740
-    | Hs_GenLoc_end = 149586457
-    | Hs_Uniprot = P48382
-    | Mm_EntrezGene = 53970
-    | Mm_Ensembl = ENSMUSG00000005774
-    | Mm_RefseqmRNA = NM_001025601
-    | Mm_RefseqProtein = NP_001020772
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 3
-    | Mm_GenLoc_start = 95039574
-    | Mm_GenLoc_end = 95046752
-    | Mm_Uniprot =
-  }}
-}}
-'''Regulatory factor X, 5 (influences HLA class II expression)''', also known as '''RFX5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RFX5 regulatory factor X, 5 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5993| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the Xbox of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.<ref name="entrez">{{cite web | title = Entrez Gene: RFX5 regulatory factor X, 5 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5993| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+RFX5 has been shown to [[Protein-protein interaction|interact]] with [[CIITA]].<ref name=pmid11003667>{{cite journal | vauthors = Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V | title = CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation | journal = Molecular and Cellular Biology | volume = 20 | issue = 20 | pages = 7716–25 | date = Oct 2000 | pmid = 11003667 | pmc = 86349 | doi = 10.1128/MCB.20.20.7716-7725.2000 }}</ref><ref name=pmid9177217>{{cite journal | vauthors = Scholl T, Mahanta SK, Strominger JL | title = Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 12 | pages = 6330–4 | date = Jun 1997 | pmid = 9177217 | pmc = 21049 | doi = 10.1073/pnas.94.12.6330 }}</ref>
+== References ==
+{{reflist}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Reith W, Mach B | title = The bare lymphocyte syndrome and the regulation of MHC expression | journal = Annual Review of Immunology | volume = 19 | issue =  | pages = 331–73 | year = 2001 | pmid = 11244040 | doi = 10.1146/annurev.immunol.19.1.331 }}
-| citations =
+* {{cite journal | vauthors = Steimle V, Durand B, Barras E, Zufferey M, Hadam MR, Mach B, Reith W | title = A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome) | journal = Genes & Development | volume = 9 | issue = 9 | pages = 1021–32 | date = May 1995 | pmid = 7744245 | doi = 10.1101/gad.9.9.1021 }}
-*{{cite journal  | author=Reith W, Mach B |title=The bare lymphocyte syndrome and the regulation of MHC expression. |journal=Annu. Rev. Immunol. |volume=19 |issue=  |pages= 331-73 |year= 2001 |pmid= 11244040 |doi= 10.1146/annurev.immunol.19.1.331 }}
+* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
-*{{cite journal  | author=Steimle V, Durand B, Barras E, ''et al.'' |title=A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). |journal=Genes Dev. |volume=9 |issue= 9 |pages= 1021-32 |year= 1995 |pmid= 7744245 |doi=  }}
+* {{cite journal | vauthors = Durand B, Sperisen P, Emery P, Barras E, Zufferey M, Mach B, Reith W | title = RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency | journal = The EMBO Journal | volume = 16 | issue = 5 | pages = 1045–55 | date = Mar 1997 | pmid = 9118943 | pmc = 1169704 | doi = 10.1093/emboj/16.5.1045 }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+* {{cite journal | vauthors = Scholl T, Mahanta SK, Strominger JL | title = Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 12 | pages = 6330–4 | date = Jun 1997 | pmid = 9177217 | pmc = 21049 | doi = 10.1073/pnas.94.12.6330 }}
-*{{cite journal  | author=Durand B, Sperisen P, Emery P, ''et al.'' |title=RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency. |journal=EMBO J. |volume=16 |issue= 5 |pages= 1045-55 |year= 1997 |pmid= 9118943 |doi= 10.1093/emboj/16.5.1045 }}
+* {{cite journal | vauthors = Moreno CS, Rogers EM, Brown JA, Boss JM | title = Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complex | journal = Journal of Immunology | volume = 158 | issue = 12 | pages = 5841–8 | date = Jun 1997 | pmid = 9190936 | doi =  }}
-*{{cite journal  | author=Scholl T, Mahanta SK, Strominger JL |title=Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6330-4 |year= 1997 |pmid= 9177217 |doi=  }}
+* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
-*{{cite journal  | author=Moreno CS, Rogers EM, Brown JA, Boss JM |title=Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complex. |journal=J. Immunol. |volume=158 |issue= 12 |pages= 5841-8 |year= 1997 |pmid= 9190936 |doi=  }}
+* {{cite journal | vauthors = Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W | title = A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients | journal = Nature Genetics | volume = 20 | issue = 3 | pages = 273–7 | date = Nov 1998 | pmid = 9806546 | doi = 10.1038/3081 }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+* {{cite journal | vauthors = Nagarajan UM, Louis-Plence P, DeSandro A, Nilsen R, Bushey A, Boss JM | title = RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency | journal = Immunity | volume = 10 | issue = 2 | pages = 153–62 | date = Feb 1999 | pmid = 10072068 | doi = 10.1016/S1074-7613(00)80016-3 }}
-*{{cite journal  | author=Villard J, Reith W, Barras E, ''et al.'' |title=Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency. |journal=Hum. Mutat. |volume=10 |issue= 6 |pages= 430-5 |year= 1998 |pmid= 9401005 |doi= 10.1002/(SICI)1098-1004(1997)10:6<430::AID-HUMU3>3.0.CO;2-H }}
+* {{cite journal | vauthors = Peijnenburg A, Van Eggermond MC, Van den Berg R, Sanal O, Vossen JM, Van den Elsen PJ | title = Molecular analysis of an MHC class II deficiency patient reveals a novel mutation in the RFX5 gene | journal = Immunogenetics | volume = 49 | issue = 4 | pages = 338–45 | date = Apr 1999 | pmid = 10079298 | doi = 10.1007/s002510050501 }}
-*{{cite journal  | author=Masternak K, Barras E, Zufferey M, ''et al.'' |title=A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. |journal=Nat. Genet. |volume=20 |issue= 3 |pages= 273-7 |year= 1998 |pmid= 9806546 |doi= 10.1038/3081 }}
+* {{cite journal | vauthors = Villard J, Peretti M, Masternak K, Barras E, Caretti G, Mantovani R, Reith W | title = A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y | journal = Molecular and Cellular Biology | volume = 20 | issue = 10 | pages = 3364–76 | date = May 2000 | pmid = 10779326 | pmc = 85629 | doi = 10.1128/MCB.20.10.3364-3376.2000 }}
-*{{cite journal  | author=Nagarajan UM, Louis-Plence P, DeSandro A, ''et al.'' |title=RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency. |journal=Immunity |volume=10 |issue= 2 |pages= 153-62 |year= 1999 |pmid= 10072068 |doi=  }}
+* {{cite journal | vauthors = Nekrep N, Jabrane-Ferrat N, Peterlin BM | title = Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex | journal = Molecular and Cellular Biology | volume = 20 | issue = 12 | pages = 4455–61 | date = Jun 2000 | pmid = 10825209 | pmc = 85813 | doi = 10.1128/MCB.20.12.4455-4461.2000 }}
-*{{cite journal  | author=Peijnenburg A, Van Eggermond MC, Van den Berg R, ''et al.'' |title=Molecular analysis of an MHC class II deficiency patient reveals a novel mutation in the RFX5 gene. |journal=Immunogenetics |volume=49 |issue= 4 |pages= 338-45 |year= 1999 |pmid= 10079298 |doi=  }}
+* {{cite journal | vauthors = Sengupta PK, Fargo J, Smith BD | title = The RFX family interacts at the collagen (COL1A2) start site and represses transcription | journal = The Journal of Biological Chemistry | volume = 277 | issue = 28 | pages = 24926–37 | date = Jul 2002 | pmid = 11986307 | doi = 10.1074/jbc.M111712200 }}
-*{{cite journal  | author=Villard J, Peretti M, Masternak K, ''et al.'' |title=A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3364-76 |year= 2000 |pmid= 10779326 |doi=  }}
+* {{cite journal | vauthors = Nekrep N, Jabrane-Ferrat N, Wolf HM, Eibl MM, Geyer M, Peterlin BM | title = Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome | journal = Nature Immunology | volume = 3 | issue = 11 | pages = 1075–81 | date = Nov 2002 | pmid = 12368908 | doi = 10.1038/ni840 }}
-*{{cite journal  | author=Nekrep N, Jabrane-Ferrat N, Peterlin BM |title=Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex. |journal=Mol. Cell. Biol. |volume=20 |issue= 12 |pages= 4455-61 |year= 2000 |pmid= 10825209 |doi=  }}
+* {{cite journal | vauthors = Xu Y, Wang L, Buttice G, Sengupta PK, Smith BD | title = Interferon gamma repression of collagen (COL1A2) transcription is mediated by the RFX5 complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 49 | pages = 49134–44 | date = Dec 2003 | pmid = 12968017 | doi = 10.1074/jbc.M309003200 }}
-*{{cite journal  | author=Sengupta PK, Fargo J, Smith BD |title=The RFX family interacts at the collagen (COL1A2) start site and represses transcription. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24926-37 |year= 2002 |pmid= 11986307 |doi= 10.1074/jbc.M111712200 }}
+* {{cite journal | vauthors = Nagarajan UM, Long AB, Harreman MT, Corbett AH, Boss JM | title = A hierarchy of nuclear localization signals governs the import of the regulatory factor X complex subunits and MHC class II expression | journal = Journal of Immunology | volume = 173 | issue = 1 | pages = 410–9 | date = Jul 2004 | pmid = 15210800 | doi = 10.4049/jimmunol.173.1.410 }}
-*{{cite journal  | author=Nekrep N, Jabrane-Ferrat N, Wolf HM, ''et al.'' |title=Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome. |journal=Nat. Immunol. |volume=3 |issue= 11 |pages= 1075-81 |year= 2002 |pmid= 12368908 |doi= 10.1038/ni840 }}
+* {{cite journal | vauthors = Hjerrild M, Stensballe A, Rasmussen TE, Kofoed CB, Blom N, Sicheritz-Ponten T, Larsen MR, Brunak S, Jensen ON, Gammeltoft S | title = Identification of phosphorylation sites in protein kinase A substrates using artificial neural networks and mass spectrometry | journal = Journal of Proteome Research | volume = 3 | issue = 3 | pages = 426–33 | year = 2004 | pmid = 15253423 | doi = 10.1021/pr0341033 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Xu Y, Wang L, Buttice G, ''et al.'' |title=Interferon gamma repression of collagen (COL1A2) transcription is mediated by the RFX5 complex. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49134-44 |year= 2004 |pmid= 12968017 |doi= 10.1074/jbc.M309003200 }}
-*{{cite journal  | author=Nagarajan UM, Long AB, Harreman MT, ''et al.'' |title=A hierarchy of nuclear localization signals governs the import of the regulatory factor X complex subunits and MHC class II expression. |journal=J. Immunol. |volume=173 |issue= 1 |pages= 410-9 |year= 2004 |pmid= 15210800 |doi=  }}
-*{{cite journal  | author=Hjerrild M, Stensballe A, Rasmussen TE, ''et al.'' |title=Identification of phosphorylation sites in protein kinase A substrates using artificial neural networks and mass spectrometry. |journal=J. Proteome Res. |volume=3 |issue= 3 |pages= 426-33 |year= 2004 |pmid= 15253423 |doi=  }}
-}}
 {{refend}}
 == External links ==
 * {{MeshName|RFX5+protein,+human}}
+* {{FactorBook|RFX5}}
+{{NLM content}}
+{{Transcription factors|g1}}
-{{protein-stub}}
-{{NLM content}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-1-stub}}

RFX5: Difference between revisions

Latest revision as of 09:09, 10 September 2017

Contents

Function

Interactions

References

Further reading

External links

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