Rat-bite fever medical therapy: Difference between revisions

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Latest revision as of 18:52, 18 September 2017

Rat-bite fever Microchapters

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Patient Information

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Rat-bite fever from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

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Treatment

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Responds to penicillin antibiotics. In cases allergic to penicillin, erythromycin or tetracyclines can be used for respectively streptobacillary or spirillary infections.

Treatment

Antimicrobial therapy

  • Streptobacillus moniliformis treatment[1]
  • 1. Migratory arthropathy and arthritis
  • Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.
  • 2. Diarrhea, (especially kids) liver or spleen abscess
  • Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.
  • 3. Undifferentiated fever
  • Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.
  • 4. Endocarditis, myocarditis, pericarditis (cardiac)
  • 5. Meningitis, brain abscess
  • 6. Anemia
  • Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.
  • 7. Pneumonia
  • Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.
  • 8. Amnionitis (pregnancy)
  • Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.
  • 9. Renal abscess
  • Preferred regimen (uncomplicated disease): Penicillin G 2.4-4.8 MU/day IV divided q6h. If better after 1 wk, switch to oral Amoxicillin OR Penicillin Vk complete 14 days.

References

  1. Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.

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