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==Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases==
==Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases==
Eosinophilic granulomatosis with polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Microscopic polyangiitis.<ref name="pmid27733943">{{cite journal| author=Pagnoux C| title=Updates in ANCA-associated vasculitis. | journal=Eur J Rheumatol | year= 2016 | volume= 3 | issue= 3 | pages= 122-133 | pmid=27733943 | doi=10.5152/eurjrheum.2015.0043 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27733943  }} </ref>
Eosinophilic granulomatosis with polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Microscopic polyangiitis.<ref name="pmid27733943">{{cite journal| author=Pagnoux C| title=Updates in ANCA-associated vasculitis. | journal=Eur J Rheumatol | year= 2016 | volume= 3 | issue= 3 | pages= 122-133 | pmid=27733943 | doi=10.5152/eurjrheum.2015.0043 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27733943  }} </ref>
{| class="wikitable"
! colspan="4" |Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis serological findings
|-
|
|Eosinophilic granulomatosis with polyangiitis
|Granulomatosis with polyangiitis
|Microscopic polyangiitis
|-
|Cytoplasmic ANCA (cANCA)
|
|90% positive
|
|-
|Perinuclear ANCA (pANCA)
|30 to 40% positive
|
|60 to 80% positive
|-
|Myeloperoxidase antigen
|†
|
|†
|-
|Proteinase 3 antigen
|
|†
|
|}
===Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases===
Eosinophilic granulomatosis with polyangiitis must be differentiated from other diseases that cause pulmonary eosinophilia and perinuclear anti-neutrophil cytoplasmic antibodies (ANCA) such as:
===Pulmonary eosinophilia===
* Parasitic infections
* Drugs
* Allergic bronchopulmonary aspergillosis
===Perinuclear ANCA===
* Cystic Fibrosis
* Bronchogenic carcinoma
* Inflammatory bowel disease
* Sclerosing cholangitis
* Myeloproliferative disorders
* Systemic lupus erythematosis
* Rheumatoid arthritis


==References==
==References==

Revision as of 14:20, 21 November 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

Eosinophilic granulomatosis with polyangiits must be differentiated from other diseases that can cause purpura, alveolar hemorrhage, fever, arthralgia, myalgia, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Microscopic polyangiitis.[1]

Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases

Eosinophilic granulomatosis with polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Granulomatosis with polyangiitis and Microscopic polyangiitis.[1]

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis serological findings
Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis Microscopic polyangiitis
Cytoplasmic ANCA (cANCA) 90% positive
Perinuclear ANCA (pANCA) 30 to 40% positive 60 to 80% positive
Myeloperoxidase antigen
Proteinase 3 antigen

Differentiating Eosinophilic granulomatosis with polyangiitis from other Diseases

Eosinophilic granulomatosis with polyangiitis must be differentiated from other diseases that cause pulmonary eosinophilia and perinuclear anti-neutrophil cytoplasmic antibodies (ANCA) such as:

Pulmonary eosinophilia

  • Parasitic infections
  • Drugs
  • Allergic bronchopulmonary aspergillosis

Perinuclear ANCA

  • Cystic Fibrosis
  • Bronchogenic carcinoma
  • Inflammatory bowel disease
  • Sclerosing cholangitis
  • Myeloproliferative disorders
  • Systemic lupus erythematosis
  • Rheumatoid arthritis


References

  1. 1.0 1.1 Pagnoux C (2016). "Updates in ANCA-associated vasculitis". Eur J Rheumatol. 3 (3): 122–133. doi:10.5152/eurjrheum.2015.0043. PMID 27733943.

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