Churg-Strauss syndrome history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

History

Obtaining a complete history is an important aspect in making a clinical diagnosis of Eosinophilic granulomatosis with polynagiitis. As it can help differentiate between the ANCA associated vasculitis and other possible causes that may mimic the disease. They include:

• Granulomatosis with polyangiitis
• Microscopic polyangiitis
• Idiopathic hyper-eosinophilic syndrome
• Drug induced

Symptoms

The initial signs that are seen in patients presenting with Eosinophilic granulomatosis with polyangiitis are non-specific in nature. The following are signs and symptoms of Eosinophilic granulomatosis with polyangiitis:

Prodromal phase

• Arthralgia
• Myalgia
• Pyrexia
• Weight loss
• Asthma
• Nasal polyps
• Allergic rhinitis,
• Sinusitis
• Otitis media
• Sensorineural hearing loss

Eosinophilic phase

• Peripheral eosinophilia
• Pulmonary infiltrates
• Ground glass opacities
• Thickening of the bronchial wall
• Endomyocardial infiltrates
• Arrhythmia
• Pericarditis
• Abdominal pain

Vascular phase

• Pyrexia
• Weight loss
• Fatigue
• Multiplex mononeuritis
• Cerebral infarctions
• Rapid progressive glomerulonephritis
• Pauci-immune focal and segmental necrotizing glomerulonephritis
• Palpable purpura and nodules
• Maculopapular erythematous
• Livedo reticularis
• Petechiae
• Ecchymoses