Strep throat pathophysiology: Difference between revisions

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===Pathogenesis===
===Pathogenesis===
<ref name="pmid10885988">{{cite journal| author=Cunningham MW| title=Pathogenesis of group A streptococcal infections. | journal=Clin Microbiol Rev | year= 2000 | volume= 13 | issue= 3 | pages= 470-511 | pmid=10885988 | doi= | pmc=88944 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10885988  }} </ref>
Pathogenesis of GAS throat involves adhesion of bacteria to pharyngeal mucosa with the help of adhesins on the surface of organism. It then invades the mucosal tissue by producing various proteases and cytolysins causing inflammation manifesting as signs and symptoms of pharyngitis.<ref name="pmid10885988">{{cite journal| author=Cunningham MW| title=Pathogenesis of group A streptococcal infections. | journal=Clin Microbiol Rev | year= 2000 | volume= 13 | issue= 3 | pages= 470-511 | pmid=10885988 | doi= | pmc=88944 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10885988  }} </ref>
M protein on the surface of group A streptococcal infection plays important role in the pathogenesis of [[rheumatic fever]].


==Transmission==
==Transmission==

Revision as of 17:52, 20 October 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]

Overview

Pathophysiology

Transmission

Direct, close contact with an infected person via respiratory droplets (cough or sneezing). Rarely, contaminated food, especially milk and milk products, can result in outbreaks.

Incubation period

The incubation period of group A strep pharyngitis is approximately 2 to 5 days.[1]

Pathogenesis

Pathogenesis of GAS throat involves adhesion of bacteria to pharyngeal mucosa with the help of adhesins on the surface of organism. It then invades the mucosal tissue by producing various proteases and cytolysins causing inflammation manifesting as signs and symptoms of pharyngitis.[2] M protein on the surface of group A streptococcal infection plays important role in the pathogenesis of rheumatic fever.

Transmission

The illness is caused by the bacterium Streptococcus pyogenes and is spread by direct, close contact with an infected person via respiratory droplets (cough or sneezing). Casual contact rarely results in transmission. Rarely, contaminated food, especially milk and milk products, can result in outbreaks. Untreated patients are most infectious for 2-3 weeks after onset of infection. The incubation period, the period after exposure and before symptoms show up, is difficult to establish as some people don't become symptomatic. However, it is thought to be between two and five days. Strep is caused by bacteria of a type called group A beta-hemolytic streptococci. Symptoms include sore throat, fever, headache, and in some cases, chills, nausea, and vomiting. The patient usually experiences swelling of the tonsils and lymph nodes in the neck.

References

  1. http://www.cdc.gov/groupastrep/diseases-hcp/strep-throat.html Accessed on October 18, 2016
  2. Cunningham MW (2000). "Pathogenesis of group A streptococcal infections". Clin Microbiol Rev. 13 (3): 470–511. PMC 88944. PMID 10885988.


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