Rotor syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Rotor syndrome
Bilirubin
ICD-10	E80.6
ICD-9	277.4
OMIM	237450
DiseasesDB	11671
MeSH	D006933

WikiDoc Resources for Rotor syndrome
Articles
Most recent articles on Rotor syndrome Most cited articles on Rotor syndrome Review articles on Rotor syndrome Articles on Rotor syndrome in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Rotor syndrome Images of Rotor syndrome Photos of Rotor syndrome Podcasts & MP3s on Rotor syndrome Videos on Rotor syndrome
Evidence Based Medicine
Cochrane Collaboration on Rotor syndrome Bandolier on Rotor syndrome TRIP on Rotor syndrome
Clinical Trials
Ongoing Trials on Rotor syndrome at Clinical Trials.gov Trial results on Rotor syndrome Clinical Trials on Rotor syndrome at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Rotor syndrome NICE Guidance on Rotor syndrome NHS PRODIGY Guidance FDA on Rotor syndrome CDC on Rotor syndrome
Books
Books on Rotor syndrome
News
Rotor syndrome in the news Be alerted to news on Rotor syndrome News trends on Rotor syndrome
Commentary
Blogs on Rotor syndrome
Definitions
Definitions of Rotor syndrome
Patient Resources / Community
Patient resources on Rotor syndrome Discussion groups on Rotor syndrome Patient Handouts on Rotor syndrome Directions to Hospitals Treating Rotor syndrome Risk calculators and risk factors for Rotor syndrome
Healthcare Provider Resources
Symptoms of Rotor syndrome Causes & Risk Factors for Rotor syndrome Diagnostic studies for Rotor syndrome Treatment of Rotor syndrome
Continuing Medical Education (CME)
CME Programs on Rotor syndrome
International
Rotor syndrome en Espanol Rotor syndrome en Francais
Business
Rotor syndrome in the Marketplace Patents on Rotor syndrome
Experimental / Informatics
List of terms related to Rotor syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]

Rotor syndrome is a rare, benign autosomal recessive disorder of unknown origin.

Presentation

It has many things in common with Dubin-Johnson syndrome except that in Rotor Syndrome, the liver cells are not pigmented. The main symptom is a non-itching jaundice. There is a rise in bilirubin in the patient's serum, mainly of the conjugated type.

	Rotor syndrome	DJS
appearance of liver	normal histology and appearance	liver has black pigmentation
gallbladder visualization	gallbladder can be visualized by oral cholecystogram	gallbladder cannot be visualized
total urine coproporphyrin content	high with <70% being isomer 1	normal with >80% being isomer 1 (normal urine contains more of isomer 3 than isomer 1)

Treatment

The liver is otherwise normal, and there is no need to treat this condition. It can be differentiated from Dubin Johnson syndrome by measuring the difference in urinary poryphrins. In Rotor syndrome there is an associated marked increase in urinary excretion of coproporyhrin I and III with < 80% being the I isomer.

Eponym

Rotor syndrome is named after the Filipino internist, Arturo Belleza Rotor (1907-1988).

See also

• Jaundice
• Bilirubin metabolism
• Dubin-Johnson syndrome
• Gilbert syndrome
• Crigler-Najjar syndrome

External links

• med/1065 at eMedicine - article on eMedicine on conjugated hyperbilirubinemia