Adult T-cell leukemia classification: Difference between revisions
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==Overview== | ==Overview== | ||
Based on both the clinical presentation and lab values, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or a lymphoma variant.<ref name="pmid18042693">{{cite journal| author=Matutes E| title=Adult T-cell leukaemia/lymphoma. | journal=J Clin Pathol | year= 2007 | volume= 60 | issue= 12 | pages= 1373-7 | pmid=18042693 | doi=10.1136/jcp.2007.052456 | pmc=PMC2095573 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18042693 }} </ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370 }} </ref> | Based on both the clinical presentation and lab values, adult T-cell leukemia may be classified into either an [[acute]] variant, [[chronic]] variant, smouldering variant, or a [[lymphoma]] variant.<ref name="pmid18042693">{{cite journal| author=Matutes E| title=Adult T-cell leukaemia/lymphoma. | journal=J Clin Pathol | year= 2007 | volume= 60 | issue= 12 | pages= 1373-7 | pmid=18042693 | doi=10.1136/jcp.2007.052456 | pmc=PMC2095573 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18042693 }} </ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370 }} </ref> | ||
==Classification== | ==Classification== | ||
* Based on both the clinical presentation and lab values, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or a lymphoma variant.<ref name="pmid18042693">{{cite journal| author=Matutes E| title=Adult T-cell leukaemia/lymphoma. | journal=J Clin Pathol | year= 2007 | volume= 60 | issue= 12 | pages= 1373-7 | pmid=18042693 | doi=10.1136/jcp.2007.052456 | pmc=PMC2095573 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18042693 }} </ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370 }} </ref> | * Based on both the clinical presentation and lab values, adult T-cell leukemia may be classified into either an [[acute]] variant, [[chronic]] variant, smouldering variant, or a [[lymphoma]] variant.<ref name="pmid18042693">{{cite journal| author=Matutes E| title=Adult T-cell leukaemia/lymphoma. | journal=J Clin Pathol | year= 2007 | volume= 60 | issue= 12 | pages= 1373-7 | pmid=18042693 | doi=10.1136/jcp.2007.052456 | pmc=PMC2095573 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18042693 }} </ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370 }} </ref> | ||
* The table below lists the details of adult T-cell leukemia clinical classification: | * The table below lists the details of adult T-cell leukemia clinical classification: | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Acute adult T-cell leukemia'''|| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Acute adult T-cell leukemia'''|| style="padding: 5px 5px; background: #F5F5F5;" | | ||
* Leukaemic clinical presentation | * Leukaemic clinical presentation | ||
* Organomegaly present | * [[Organomegaly]] present | ||
* Markedly elevated lactate dehydrogenase (LDH) level | * Markedly elevated lactate dehydrogenase ([[LDH]]) level | ||
* Hypercalcaemia | * [[Hypercalcaemia]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Chronic adult T-cell leukemia'''|| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Chronic adult T-cell leukemia'''|| style="padding: 5px 5px; background: #F5F5F5;" | | ||
* Lymphocyte count greater than 4×10<sup>9</sup>/L | * [[Lymphocyte]] count greater than 4×10<sup>9</sup>/L | ||
* Cutaneous, pulmonary, and hepatic involvement | * [[Cutaneous]], [[pulmonary]], and [[hepatic]] involvement | ||
* Lymphadenopathy | * [[Lymphadenopathy]] | ||
* Normal serum LDH level (or less that twice the normal upper limit) | * Normal serum LDH level (or less that twice the normal upper limit) | ||
* Normal serum calcium level | * Normal serum calcium level | ||
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* Cutaneous and/or pulmonary infiltrates | * Cutaneous and/or pulmonary infiltrates | ||
* No other organ involvement | * No other organ involvement | ||
* Normal lymphocyte count (1–5% ATLL cells) | * Normal [[lymphocyte]] count (1–5% ATLL cells) | ||
* Normal serum LDH level | * Normal serum LDH level | ||
* Normal serum calcium level | * Normal serum [[calcium]] level | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Adult T-cell lymphoma'''|| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Adult T-cell lymphoma'''|| style="padding: 5px 5px; background: #F5F5F5;" | | ||
* Organomegaly present | * [[Organomegaly]] present | ||
* Less than 1% leukaemic cells in the circulation | * Less than 1% leukaemic cells in the circulation | ||
* Elevated serum LDH level | * Elevated serum [[LDH]] level | ||
* Hypercalcaemia | * [[Hypercalcaemia]] | ||
|} | |} | ||
Revision as of 16:16, 22 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Based on both the clinical presentation and lab values, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or a lymphoma variant.[1][2]
Classification
- Based on both the clinical presentation and lab values, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or a lymphoma variant.[1][2]
- The table below lists the details of adult T-cell leukemia clinical classification:
| Clinical Variant | Description |
|---|---|
| Acute adult T-cell leukemia |
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| Chronic adult T-cell leukemia |
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| Smouldering adult T-cell leukemia |
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| Adult T-cell lymphoma |
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References
- ↑ 1.0 1.1 Matutes E (2007). "Adult T-cell leukaemia/lymphoma". J Clin Pathol. 60 (12): 1373–7. doi:10.1136/jcp.2007.052456. PMC 2095573. PMID 18042693.
- ↑ 2.0 2.1 Shimoyama M (1991). "Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87)". Br J Haematol. 79 (3): 428–37. PMID 1751370.