Ovarian germ cell tumor overview: Difference between revisions
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==Overveiw== | ==Overveiw== | ||
Ovarian germ cell tumor is a disease in which [[malignant]] cells form in the germ cells of the ovary. Germ cell tumors begin in the reproductive cells of the body. Ovarian germ cell tumor are rare tumors, accounting for 2% to 3% of all ovarian cancers. The median age for [[diagnosis]] is 16 to 20 (range 6 to 40 years).<ref name=dfg> Updates in the Management of Ovarian Germ Cell Tumors. http://meetinglibrary.asco.org/content/31-132. URL Accessed on November 11, 2015</ref> Ovarian germ cell tumor may be classified into 7 subtypes based on [[histology]].<ref name=abc> Cellular Classification of Ovarian Germ Cell Tumors. http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_. URL Accessed on November 4, 2015</ref> The most common ovarian germ cell tumor is called [[dysgerminoma]]. Abnormal [[gonad]]s (due to [[gonadal dysgenesis]] and [[androgen insensitivity syndrome]]) have a high risk of developing a dysgerminoma. Ovarian germ cell tumor must be differentiated from other [[neoplastic]] [[ovarian]] mass, non neoplastic ovarian mass, and adnexal mass. Symptoms of ovarian germ cell tumor include [[abdominal distention]], acute/ sub acute [[abdominal pain]], [[menstrual irregularities]], and [[precocious puberty]].<ref name= lmn>{{cite book | last = Hoffman | first = Barbara | title = Williams gynecology | publisher = McGraw-Hill Medical | location = New York | year = 2012 | isbn = 9780071716727 }}</ref> Physical examination of patients with ovarian germ cell tumor is usually remarkable for [[vaginal bleeding]], [[abdominal distention]], and adnexal mass.<ref name= lmn>{{cite book | last = Hoffman | first = Barbara | title = Williams gynecology | publisher = McGraw-Hill Medical | location = New York | year = 2012 | isbn = 9780071716727 }}</ref> The laboratory findings associated with ovarian germ cell tumor are the following: serum [[lactate dehydrogenase]] (LDH), [[human chorionic gonadotropin]] (HCG), [[CA-125]], and [[alpha-fetoprotein]] (AFP). | |||
==Classification== | ==Classification== | ||
Ovarian germ cell tumor may be classified into 7 subtypes based on histology.<ref name=abc> Cellular Classification of Ovarian Germ Cell Tumors. http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_. URL Accessed on November 4, 2015</ref> | Ovarian germ cell tumor may be classified into 7 subtypes based on histology.<ref name=abc> Cellular Classification of Ovarian Germ Cell Tumors. http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_. URL Accessed on November 4, 2015</ref> | ||
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==Differentiating From Ovarian Germ Cell Tumor Other Diseases== | ==Differentiating From Ovarian Germ Cell Tumor Other Diseases== | ||
Ovarian germ cell tumor must be differentiated from other neoplastic ovarian mass, non neoplastic ovarian mass, and adnexal mass. | Ovarian germ cell tumor must be differentiated from other [[neoplastic]] [[ovarian]] mass, non neoplastic ovarian mass, and adnexal mass. | ||
==Staging== | ==Staging== | ||
Revision as of 21:48, 18 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Overveiw
Ovarian germ cell tumor is a disease in which malignant cells form in the germ cells of the ovary. Germ cell tumors begin in the reproductive cells of the body. Ovarian germ cell tumor are rare tumors, accounting for 2% to 3% of all ovarian cancers. The median age for diagnosis is 16 to 20 (range 6 to 40 years).[1] Ovarian germ cell tumor may be classified into 7 subtypes based on histology.[2] The most common ovarian germ cell tumor is called dysgerminoma. Abnormal gonads (due to gonadal dysgenesis and androgen insensitivity syndrome) have a high risk of developing a dysgerminoma. Ovarian germ cell tumor must be differentiated from other neoplastic ovarian mass, non neoplastic ovarian mass, and adnexal mass. Symptoms of ovarian germ cell tumor include abdominal distention, acute/ sub acute abdominal pain, menstrual irregularities, and precocious puberty.[3] Physical examination of patients with ovarian germ cell tumor is usually remarkable for vaginal bleeding, abdominal distention, and adnexal mass.[3] The laboratory findings associated with ovarian germ cell tumor are the following: serum lactate dehydrogenase (LDH), human chorionic gonadotropin (HCG), CA-125, and alpha-fetoprotein (AFP).
Classification
Ovarian germ cell tumor may be classified into 7 subtypes based on histology.[2]
Pathophysiology
It is difficult to distinguish subtypes of ovarian germ cell tumor on gross pathology alone. The majority of ovarian germ cell tumors have a solid and cystic appearance with areas of hemorrhage and necrosis. On microscopic pathology, ovarian germ cell tumors may be characterized by a uniform “fried egg” appearance (dysgerminoma), presence of Schiller-Duval bodies (yolk sac tumor), presence of embryonic-like neural, GI, and/or cartilaginous tissue (teratoma), or mixed histopathological features (embryonal cell carcinoma).
Epidemiology and Demographics
Ovarian germ cell tumor are rare tumors, accounting for 2% to 3% of all ovarian cancers. The median age for diagnosis is 16 to 20 (range 6 to 40 years)[1]
Risk Factors
Abnormal gonads (due to gonadal dysgenesis and androgen insensitivity syndrome) have a high risk of developing a dysgerminoma.[4]
Differentiating From Ovarian Germ Cell Tumor Other Diseases
Ovarian germ cell tumor must be differentiated from other neoplastic ovarian mass, non neoplastic ovarian mass, and adnexal mass.
Staging
According to the FIGO cancer staging system, there are 4 stages of ovarian germ cell tumor.
History and Symptoms
Symptoms of ovarian germ cell tumor include abdominal distention, acute/ sub acute abdominal pain, menstrual irregularities, and precocious puberty.[3]
Ovarian Germ Cell Tumor Physical Examination
Physical examination of patients with ovarian germ cell tumor is usually remarkable for vaginal bleeding, abdominal distention, and adnexal mass.[3]
Ovarian germ cell tumor Laboratory Findings
The laboratory findings associated with ovarian germ cell tumor are the following: serum lactate dehydrogenase (LDH), human chorionic gonadotropin (HCG), CA-125, and alpha-fetoprotein (AFP).[5]
CT
It is difficult to distinguish ovarian germ cell tumors on CT alone. Dysgerminoma often appears as multilobulated solid masses with prominent fibrovascular septa while, mature ovarian teratoma may demonstrate fat (areas with very low Hounsfield values), fat-fluid level, calcification (sometimes dentiform), Rokitansky protuberance, and tufts of hair.[6][7][8]
MRI
It is difficult to distinguish subtypes of ovarian germ cell tumor on MRI alone. The majority of ovarian germ cell tumors have a solid and cystic appearance with areas of hemorrhage and necrosis. On MRI, ovarian germ cell tumors may be characterized by T2: the septae are often hypointense or isointense 3 T1 C+ (Gd): the septae often show marked enhancement (dysgerminoma), the presence of a prominent solid component containing calcifications and small foci of fat (mature teratoma), areas of haemorrhage can also be seen (yolk sac tumor).[6][7][8]
Ultrasound
It is difficult to distinguish ovarian germ cell tumors on ultrasound alone. Both solid and cystic lesions with calcification may be present. Dysgerminoma often appears as a hypoechoic mass while other ovarian germ cell tumors often have variable echogenicity. Ovarian teratoma may be further characterized by the presence of sebaceous and hair components arising from the rokitansky protuberance.[6][7][8][9]
References
- ↑ 1.0 1.1 Updates in the Management of Ovarian Germ Cell Tumors. http://meetinglibrary.asco.org/content/31-132. URL Accessed on November 11, 2015
- ↑ 2.0 2.1 Cellular Classification of Ovarian Germ Cell Tumors. http://www.cancer.gov/types/ovarian/hp/ovarian-germ-cell-treatment-pdq#section/_. URL Accessed on November 4, 2015
- ↑ 3.0 3.1 3.2 3.3 Hoffman, Barbara (2012). Williams gynecology. New York: McGraw-Hill Medical. ISBN 9780071716727.
- ↑ Kliegman, Robert (2011). Nelson textbook of pediatrics. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4377-0755-7.
- ↑ Ovary: Germ cell tumors. http://atlasgeneticsoncology.org/Tumors/OvarianGermCellID5067.html. URL Accessed on November 10, 2015
- ↑ 6.0 6.1 6.2 Ovarian dysgerminoma. http://radiopaedia.org/articles/ovarian-dysgerminoma. URL Accessed on November 11, 2015
- ↑ 7.0 7.1 7.2 Mature (cystic) ovarian teratoma. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma. URL Accessed on November 11, 2015
- ↑ 8.0 8.1 8.2 Immature ovarian teratoma. http://radiopaedia.org/articles/immature-ovarian-teratoma. URL Accessed on November 11, 2015
- ↑ Immature ovarian teratoma. http://radiopaedia.org/articles/immature-ovarian-teratoma. URL Accessed on November 11, 2015