Multiple endocrine neoplasia type 2 risk factors: Difference between revisions
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:* [[Family history]] | :* [[Family history]] | ||
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[[Category:Endocrine system]] | |||
[[Category:Genetic disorders]] | |||
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Revision as of 15:00, 28 September 2015
Multiple endocrine neoplasia type 2 Microchapters |
Differentiating Multiple endocrine neoplasia type 2 from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]
Overview
Common risk factor in the development of multiple endocrine neoplasia type 2 is family history.
Risk Factors
- Common risk factor in the development of multiple endocrine neoplasia type 2 is given below.[1]
- During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999 [6], the risk of MTC has been stratified in three categories according to the mutations of c-RET as following.
Gene | Risk |
---|---|
Children with MEN2B and/or c-RET codon 883, 918,
922 |
Highest risk of aggressive MTC |
Children with any c-RET codon 611, 618, 620 or 634
mutations |
High risk of MTC |
Children with c-RET codon 609, 768, 790, 791, 804
and 891 mutations |
Less aggressive and slowly growing MTC |