Multiple endocrine neoplasia type 1 epidemiology and demographics: Difference between revisions
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* Endocrine and non-[[endocrine]] manifestations of the [[disease]] in MEN1 patients most often begin in the fourth or fifth decade. The onset of the [[disease]] is rare before age 10 years.<ref name="pmiddoi:10.1016/j.beem.2010.07.003">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=doi:10.1016/j.beem.2010.07.003 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | * Endocrine and non-[[endocrine]] manifestations of the [[disease]] in MEN1 patients most often begin in the fourth or fifth decade.<ref name="pmid17014705">{{cite journal| author=Marini F, Falchetti A, Del Monte F, Carbonell Sala S, Gozzini A, Luzi E et al.| title=Multiple endocrine neoplasia type 1. | journal=Orphanet J Rare Dis | year= 2006 | volume= 1 | issue= | pages= 38 | pmid=17014705 | doi=10.1186/1750-1172-1-38 | pmc=PMC1594566 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17014705 }} </ref> The onset of the [[disease]] is rare before age 10 years.<ref name="pmiddoi:10.1016/j.beem.2010.07.003">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=doi:10.1016/j.beem.2010.07.003 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | ||
==Gender== | ==Gender== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]
Overview
Epidemiology and Demographics
Prevalence
- Worldwide, the prevalence of multiple endocrine neoplasia type 1 is estimated to be 2-3 per 100,000.[1]
- Multiple endocrine neoplasia type 1 is a rare disease that occurs in approximately one in 30,000 individuals.
Age
- Endocrine and non-endocrine manifestations of the disease in MEN1 patients most often begin in the fourth or fifth decade.[2] The onset of the disease is rare before age 10 years.[3]
Gender
- Men and women are affected equally by multiple endocrine neoplasia type 1.[3][4]
- Males have a higher incidence of pancreatic tumors.
- Females have a higher incidence of pituitary tumors.
- Thymic tumors are found in men.
Race
- The prevalence of multiple endocrine neoplasia type 1 does not vary by race.
Geographic Distribution
- There is no geographic preferences for the incidence of multiple endocrine neoplasia type 1.
References
- ↑ [1] C. Romei, E. Pardi, F. Cetani, and R. Elisei, “Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2,” Journal of Oncology, vol. 2012, Article ID 705036, 15 pages, 2012. doi:10.1155/2012/705036
- ↑ Marini F, Falchetti A, Del Monte F, Carbonell Sala S, Gozzini A, Luzi E; et al. (2006). "Multiple endocrine neoplasia type 1". Orphanet J Rare Dis. 1: 38. doi:10.1186/1750-1172-1-38. PMC 1594566. PMID 17014705.
- ↑ 3.0 3.1 Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID doi:10.1016/j.beem.2010.07.003 Check
|pmid=value (help). - ↑ Goudet P, Bonithon-Kopp C, Murat A, Ruszniewski P, Niccoli P, Ménégaux F; et al. (2011). "Gender-related differences in MEN1 lesion occurrence and diagnosis: a cohort study of 734 cases from the Groupe d'etude des Tumeurs Endocrines". Eur J Endocrinol. 165 (1): 97–105. doi:10.1530/EJE-10-0950. PMID 21551167.