SLC32A1: Difference between revisions

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Latest revision as of 06:31, 11 September 2017

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.^[1]

The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.^[1]

References

↑ ^1.0 ^1.1 "Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1".

McIntire SL, Reimer RJ, Schuske K, et al. (1997). "Identification and characterization of the vesicular GABA transporter". Nature. 389 (6653): 870–6. doi:10.1038/39908. PMID 9349821.
Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain". Hum. Genet. 103 (6): 666–73. doi:10.1007/s004390050889. PMID 9921901.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Chessler SD, Simonson WT, Sweet IR, Hammerle LP (2002). "Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets". Diabetes. 51 (6): 1763–71. doi:10.2337/diabetes.51.6.1763. PMID 12031963.
Jellali A, Stussi-Garaud C, Gasnier B, et al. (2002). "Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina". J. Comp. Neurol. 449 (1): 76–87. doi:10.1002/cne.10272. PMID 12115694.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Geigerseder C, Doepner R, Thalhammer A, et al. (2003). "Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors". Neuroendocrinology. 77 (5): 314–23. doi:10.1159/000070897. PMID 12806177.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[entrez-1] 1.0 ^1.1 "Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1".

[1]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Vesicular inhibitory amino acid transporter''' is a [[protein]] that in humans is encoded by the ''SLC32A1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140679| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 32 (GABA vesicular transporter), member 1
- | HGNCid = 11018
- | Symbol = SLC32A1
- | AltSymbols =; VGAT; VIAAT
- | OMIM =
- | ECnumber =
- | Homologene = 56451
- | MGIid = 1194488
- | GeneAtlas_image1 = PBB_GE_SLC32A1_gnf1h08592_at_tn.png
- | Function = {{GNF_GO|id=GO:0015187 |text = glycine transmembrane transporter activity}} {{GNF_GO|id=GO:0015495 |text = gamma-aminobutyric acid:hydrogen symporter activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006836 |text = neurotransmitter transport}} {{GNF_GO|id=GO:0015816 |text = glycine transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 140679
-    | Hs_Ensembl = ENSG00000101438
-    | Hs_RefseqProtein = NP_542119
-    | Hs_RefseqmRNA = NM_080552
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 20
-    | Hs_GenLoc_start = 36786519
-    | Hs_GenLoc_end = 36791429
-    | Hs_Uniprot = Q9H598
-    | Mm_EntrezGene = 22348
-    | Mm_Ensembl = ENSMUSG00000037771
-    | Mm_RefseqmRNA = XM_979351
-    | Mm_RefseqProtein = XP_984445
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 158302199
-    | Mm_GenLoc_end = 158307188
-    | Mm_Uniprot = Q49S98
-  }}
-}}
-'''Solute carrier family 32 (GABA vesicular transporter), member 1''', also known as '''SLC32A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140679| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.<ref name="entrez">{{cite web | title = Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140679| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene is an integral membrane protein involved in [[gamma-aminobutyric acid]] (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.<ref name="entrez" />
 }}
@@ Line 58: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 64: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=McIntire SL, Reimer RJ, Schuske K, ''et al.'' |title=Identification and characterization of the vesicular GABA transporter. |journal=Nature |volume=389 |issue= 6653 |pages= 870-6 |year= 1997 |pmid= 9349821 |doi= 10.1038/39908 }}
+*{{cite journal   |vauthors=McIntire SL, Reimer RJ, Schuske K, etal |title=Identification and characterization of the vesicular GABA transporter |journal=Nature |volume=389 |issue= 6653 |pages= 870–6 |year= 1997 |pmid= 9349821 |doi= 10.1038/39908 }}
-*{{cite journal  | author=Kleiderlein JJ, Nisson PE, Jessee J, ''et al.'' |title=CCG repeats in cDNAs from human brain. |journal=Hum. Genet. |volume=103 |issue= 6 |pages= 666-73 |year= 1999 |pmid= 9921901 |doi=  }}
+*{{cite journal   |vauthors=Kleiderlein JJ, Nisson PE, Jessee J, etal |title=CCG repeats in cDNAs from human brain |journal=Hum. Genet. |volume=103 |issue= 6 |pages= 666–73 |year= 1999 |pmid= 9921901 |doi=10.1007/s004390050889  }}
-*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
+*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
-*{{cite journal  | author=Chessler SD, Simonson WT, Sweet IR, Hammerle LP |title=Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets. |journal=Diabetes |volume=51 |issue= 6 |pages= 1763-71 |year= 2002 |pmid= 12031963 |doi=  }}
+*{{cite journal  | vauthors=Chessler SD, Simonson WT, Sweet IR, Hammerle LP |title=Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets |journal=Diabetes |volume=51 |issue= 6 |pages= 1763–71 |year= 2002 |pmid= 12031963 |doi=10.2337/diabetes.51.6.1763  }}
-*{{cite journal  | author=Jellali A, Stussi-Garaud C, Gasnier B, ''et al.'' |title=Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina. |journal=J. Comp. Neurol. |volume=449 |issue= 1 |pages= 76-87 |year= 2002 |pmid= 12115694 |doi= 10.1002/cne.10272 }}
+*{{cite journal   |vauthors=Jellali A, Stussi-Garaud C, Gasnier B, etal |title=Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina |journal=J. Comp. Neurol. |volume=449 |issue= 1 |pages= 76–87 |year= 2002 |pmid= 12115694 |doi= 10.1002/cne.10272 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Geigerseder C, Doepner R, Thalhammer A, ''et al.'' |title=Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors. |journal=Neuroendocrinology |volume=77 |issue= 5 |pages= 314-23 |year= 2003 |pmid= 12806177 |doi= 10.1159/000070897 }}
+*{{cite journal   |vauthors=Geigerseder C, Doepner R, Thalhammer A, etal |title=Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors |journal=Neuroendocrinology |volume=77 |issue= 5 |pages= 314–23 |year= 2003 |pmid= 12806177 |doi= 10.1159/000070897 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{Membrane transport proteins}}
+{{GABA metabolism and transport modulators}}
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+{{PBB_Controls
+| update_page = yes
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+}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+[[Category:Neurotransmitter transporters]]
+{{membrane-protein-stub}}

SLC32A1: Difference between revisions

Latest revision as of 06:31, 11 September 2017

See also

References

Further reading

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