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{{ | '''Nuclear factor 1 X-type''' is a [[protein]] that in humans is encoded by the ''NFIX'' [[gene]].<ref name="pmid8340106">{{cite journal | vauthors = Seisenberger C, Winnacker EL, Scherthan H | title = Localisation of the human nuclear factor I/X (NFI/X) gene to chromosome 19p13 and detection of five other related loci at 1p21-22, 1q42-43, 5q15, 11p13 and 20q13 by FISH | journal = Hum Genet | volume = 91 | issue = 6 | pages = 535–7 | date = Aug 1993 | pmid = 8340106 | pmc = | doi = 10.1007/bf00205076 }}</ref><ref name="pmid7590749">{{cite journal | vauthors = Qian F, Kruse U, Lichter P, Sippel AE | title = Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH | journal = Genomics | volume = 28 | issue = 1 | pages = 66–73 | date = Dec 1995 | pmid = 7590749 | pmc = | doi = 10.1006/geno.1995.1107 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4784| accessdate = }}</ref> NFI-X3, a [[Alternative splicing|splice variant]] of NFIX, regulates [[Glial fibrillary acidic protein]] and [[CHI3L1|YKL-40]] in [[astrocyte]]s.<ref name="pmid21953450">{{cite journal | vauthors = Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, Kordula T | title = A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40 | journal = J. Biol. Chem. | volume = 286 | issue = 46 | pages = 39893–903 | date = November 2011 | pmid = 21953450 | pmc = 3220556 | doi = 10.1074/jbc.M111.257451 }}</ref> | ||
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== Interactions == | |||
NFIX has been shown to [[Protein-protein interaction|interact]] with [[SKI protein]]<ref name="pmid9380514">{{cite journal | vauthors = Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E | title = DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI | journal = Nucleic Acids Res. | volume = 25 | issue = 19 | pages = 3895–903 | date = October 1997 | pmid = 9380514 | pmc = 146989 | doi = 10.1093/nar/25.19.3895 }}</ref> and it is also known to interact with [[AP-1 (transcription factor)|AP-1]].<ref name="pmid21953450"/> NFI-X3 has been shown to interact with [[STAT3]].<ref name="pmid21953450"/> | |||
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==References== | == References == | ||
{{reflist | {{reflist}} | ||
==Further reading== | {{Clear}} | ||
== Further reading == | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Apt D, Liu Y, Bernard HU | title = Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner. | journal = Nucleic Acids Res. | volume = 22 | issue = 19 | pages = 3825–33 | year = 1994 | pmid = 7937100 | pmc = 308376 | doi = 10.1093/nar/22.19.3825 }} | |||
* {{cite journal | vauthors = Sumner C, Shinohara T, Durham L, Traub R, Major EO, Amemiya K | title = Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes. | journal = J. Neurovirol. | volume = 2 | issue = 2 | pages = 87–100 | year = 1996 | pmid = 8799200 | doi = 10.3109/13550289609146542 }} | |||
*{{cite journal | * {{cite journal | vauthors = Wendler WM, Kremmer E, Förster R, Winnacker EL | title = Identification of pirin, a novel highly conserved nuclear protein. | journal = J. Biol. Chem. | volume = 272 | issue = 13 | pages = 8482–9 | year = 1997 | pmid = 9079676 | doi = 10.1074/jbc.272.13.8482 }} | ||
* {{cite journal | vauthors = Liu Y, Bernard HU, Apt D | title = NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing. | journal = J. Biol. Chem. | volume = 272 | issue = 16 | pages = 10739–45 | year = 1997 | pmid = 9099724 | doi = 10.1074/jbc.272.16.10739 }} | |||
* {{cite journal | vauthors = Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E | title = DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI. | journal = Nucleic Acids Res. | volume = 25 | issue = 19 | pages = 3895–903 | year = 1997 | pmid = 9380514 | pmc = 146989 | doi = 10.1093/nar/25.19.3895 }} | |||
*{{cite journal | * {{cite journal | vauthors = Müller K, Mermod N | title = The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo. | journal = J. Biol. Chem. | volume = 275 | issue = 3 | pages = 1645–50 | year = 2000 | pmid = 10636857 | doi = 10.1074/jbc.275.3.1645 }} | ||
*{{cite journal | * {{cite journal | vauthors = Nakazato M, Chung HK, Ulianich L, Grassadonia A, Suzuki K, Kohn LD | title = Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression. | journal = Mol. Cell. Biol. | volume = 20 | issue = 22 | pages = 8499–512 | year = 2000 | pmid = 11046146 | pmc = 102156 | doi = 10.1128/MCB.20.22.8499-8512.2000 }} | ||
*{{cite journal | * {{cite journal | vauthors = Imagawa M, Sakaue R, Tanabe A, Osada S, Nishihara T | title = Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A. | journal = FEBS Lett. | volume = 484 | issue = 2 | pages = 118–24 | year = 2000 | pmid = 11068044 | doi = 10.1016/S0014-5793(00)02119-0 }} | ||
*{{cite journal | * {{cite journal | vauthors = Norquay LD, Yang X, Sheppard P, Gregoire S, Dodd JG, Reith W, Cattini PA | title = RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin. | journal = Mol. Endocrinol. | volume = 17 | issue = 6 | pages = 1027–38 | year = 2003 | pmid = 12624117 | doi = 10.1210/me.2003-0025 }} | ||
*{{cite journal | * {{cite journal | vauthors = Gopalan SM, Wilczynska KM, Konik BS, Bryan L, Kordula T | title = Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes. | journal = J. Biol. Chem. | volume = 281 | issue = 19 | pages = 13126–33 | year = 2006 | pmid = 16565071 | doi = 10.1074/jbc.M601194200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Ravichandran V, Sabath BF, Jensen PN, Houff SA, Major EO | title = Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism. | journal = J. Virol. | volume = 80 | issue = 21 | pages = 10506–13 | year = 2006 | pmid = 16928756 | pmc = 1641797 | doi = 10.1128/JVI.01355-06 }} | ||
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{{refend}} | {{refend}} | ||
== External links == | == External links == | ||
* {{MeshName|NFIX+protein,+human}} | * {{MeshName|NFIX+protein,+human}} | ||
{{NLM content}} | |||
{{Transcription factors|g1}} | |||
[[Category:Transcription factors]] | |||
{{gene-19-stub}} | {{gene-19-stub}} | ||
Latest revision as of 12:52, 5 September 2017
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Location (UCSC) | n/a | n/a | |||||
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Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene.[1][2][3] NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.[4]
Interactions
NFIX has been shown to interact with SKI protein[5] and it is also known to interact with AP-1.[4] NFI-X3 has been shown to interact with STAT3.[4]
References
- ↑ Seisenberger C, Winnacker EL, Scherthan H (Aug 1993). "Localisation of the human nuclear factor I/X (NFI/X) gene to chromosome 19p13 and detection of five other related loci at 1p21-22, 1q42-43, 5q15, 11p13 and 20q13 by FISH". Hum Genet. 91 (6): 535–7. doi:10.1007/bf00205076. PMID 8340106.
- ↑ Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
- ↑ "Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)".
- ↑ 4.0 4.1 4.2 Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, Kordula T (November 2011). "A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40". J. Biol. Chem. 286 (46): 39893–903. doi:10.1074/jbc.M111.257451. PMC 3220556. PMID 21953450.
- ↑ Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E (October 1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514.
Further reading
- Apt D, Liu Y, Bernard HU (1994). "Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner". Nucleic Acids Res. 22 (19): 3825–33. doi:10.1093/nar/22.19.3825. PMC 308376. PMID 7937100.
- Sumner C, Shinohara T, Durham L, Traub R, Major EO, Amemiya K (1996). "Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes". J. Neurovirol. 2 (2): 87–100. doi:10.3109/13550289609146542. PMID 8799200.
- Wendler WM, Kremmer E, Förster R, Winnacker EL (1997). "Identification of pirin, a novel highly conserved nuclear protein". J. Biol. Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.
- Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724.
- Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E (1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. 25 (19): 3895–903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514.
- Müller K, Mermod N (2000). "The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo". J. Biol. Chem. 275 (3): 1645–50. doi:10.1074/jbc.275.3.1645. PMID 10636857.
- Nakazato M, Chung HK, Ulianich L, Grassadonia A, Suzuki K, Kohn LD (2000). "Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression". Mol. Cell. Biol. 20 (22): 8499–512. doi:10.1128/MCB.20.22.8499-8512.2000. PMC 102156. PMID 11046146.
- Imagawa M, Sakaue R, Tanabe A, Osada S, Nishihara T (2000). "Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A". FEBS Lett. 484 (2): 118–24. doi:10.1016/S0014-5793(00)02119-0. PMID 11068044.
- Norquay LD, Yang X, Sheppard P, Gregoire S, Dodd JG, Reith W, Cattini PA (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.
- Gopalan SM, Wilczynska KM, Konik BS, Bryan L, Kordula T (2006). "Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes". J. Biol. Chem. 281 (19): 13126–33. doi:10.1074/jbc.M601194200. PMID 16565071.
- Ravichandran V, Sabath BF, Jensen PN, Houff SA, Major EO (2006). "Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism". J. Virol. 80 (21): 10506–13. doi:10.1128/JVI.01355-06. PMC 1641797. PMID 16928756.
External links
- NFIX+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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