MAP1LC3A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Microtubule-associated proteins 1A/1B light chain 3A''' is a [[protein]] that in humans is encoded by the ''MAP1LC3A'' [[gene]].<ref name="pmid8833088">{{cite journal |vauthors=Mann SS, Hammarback JA | title = Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B | journal = J Neurosci Res | volume = 43 | issue = 5 | pages = 535–44 |date=May 1997 | pmid = 8833088 | pmc =  | doi = 10.1002/(SICI)1097-4547(19960301)43:5<535::AID-JNR3>3.0.CO;2-J }}</ref><ref name="pmid17580304">{{cite journal |vauthors=Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T | title = p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy | journal = J Biol Chem | volume = 282 | issue = 33 | pages = 24131–45 |date=Aug 2007 | pmid = 17580304 | pmc = | doi = 10.1074/jbc.M702824200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84557| accessdate = }}</ref> Two transcript variants encoding different isoforms have been found for this gene.
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Microtubule-associated protein 1 light chain 3 alpha
| HGNCid = 6838
| Symbol = MAP1LC3A
| AltSymbols =; MAP1ALC3; MAP1BLC3
| OMIM = 601242
| ECnumber = 
| Homologene = 12021
| MGIid = 1915661
| Function =  
| Component = {{GNF_GO|id=GO:0005776 |text = autophagic vacuole}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0031090 |text = organelle membrane}}
| Process = {{GNF_GO|id=GO:0000045 |text = autophagic vacuole formation}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0006914 |text = autophagy}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84557
    | Hs_Ensembl = ENSG00000101460
    | Hs_RefseqProtein = NP_115903
    | Hs_RefseqmRNA = NM_032514
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 32598319
    | Hs_GenLoc_end = 32611810
    | Hs_Uniprot = Q9H492
    | Mm_EntrezGene = 66734
    | Mm_Ensembl = ENSMUSG00000027602
    | Mm_RefseqmRNA = NM_025735
    | Mm_RefseqProtein = NP_080011
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 154967885
    | Mm_GenLoc_end = 154969513
    | Mm_Uniprot = Q91VR7
  }}
}}
'''Microtubule-associated protein 1 light chain 3 alpha''', also known as '''MAP1LC3A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84557| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[MAP1A]] and [[MAP1B]] are [[microtubule]]-associated proteins which mediate the physical interactions between microtubules and components of the [[cytoskeleton]]. [[MAP1A]] and [[MAP1B]] each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
MAPLC3A is one of the mammalian homologues of yeast [[ATG8]], an important marker and effector of [[autophagy]].<ref>{{Cite journal|pmc = 4127242|title = Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer|vauthors=Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, Alabiso O, Arisio R, Katsaros D, Benedetto C, Isidoro C |date = 2014|journal = Biomed Res Int|doi = 10.1155/2014/462658|pmid = 25136588|volume = 2014|page = 462658}}</ref>
| summary_text = MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84557| accessdate = }}</ref>
 
}}
== Regulation ==
 
MAP1LC3A is regulated by several [[post-translational modification]]s. These include covalent linkage of the [[C-terminus]] to [[phosphatidylethanolamine]] in autophagic membranes, and [[phosphorylation]] by [[protein kinase A]],<ref name="pmid20713600">{{cite journal |vauthors=Cherra SJ, Kulich SM, Uechi G, Balasubramani M, Mountzouris J, Day BW, Chu CT | title = Regulation of the autophagy protein LC3 by phosphorylation | journal = J. Cell Biol. | volume = 190 | issue = 4 | pages = 533–9 |date=August 2010 | pmid = 20713600 | pmc = 2928022 | doi = 10.1083/jcb.201002108 }}</ref> which downregulates its autophagy functions. Noncovalent interactions are important for its cargo targeting functions in selective autophagy. For example, it has been shown to [[Protein-protein interaction|interact]] with [[sequestosome 1]].<ref name="pmid18653543">{{cite journal |vauthors=Shvets E, Fass E, Scherz-Shouval R, Elazar Z | title = The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes | journal = J. Cell Sci. | volume = 121 | issue = Pt 16 | pages = 2685–95 |date=August 2008 | pmid = 18653543 | doi = 10.1242/jcs.026005 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227–30 |year= 1997 |pmid= 8997639 |doi=  10.1007/BF02818986}}
| citations =
*{{cite journal  |vauthors=Wallin M, Deinum J, Goobar L, Danielson UH |title=Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases |journal=J. Gen. Virol. |volume=71 |issue=  9|pages= 1985–91 |year= 1990 |pmid= 2212989 |doi=10.1099/0022-1317-71-9-1985  }}
*{{cite journal  | author=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227-30 |year= 1997 |pmid= 8997639 |doi=  }}
*{{cite journal  |vauthors=Schoenfeld TA, McKerracher L, Obar R, Vallee RB |title=MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS |journal=J. Neurosci. |volume=9 |issue= 5 |pages= 1712–30 |year= 1989 |pmid= 2470876 |doi=  }}
*{{cite journal  | author=Wallin M, Deinum J, Goobar L, Danielson UH |title=Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases. |journal=J. Gen. Virol. |volume=71 ( Pt 9) |issue=  |pages= 1985-91 |year= 1990 |pmid= 2212989 |doi= }}
*{{cite journal  |vauthors=Mann SS, Hammarback JA |title=Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11492–7 |year= 1994 |pmid= 7908909 |doi=  }}
*{{cite journal  | author=Schoenfeld TA, McKerracher L, Obar R, Vallee RB |title=MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS. |journal=J. Neurosci. |volume=9 |issue= 5 |pages= 1712-30 |year= 1989 |pmid= 2470876 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
*{{cite journal  | author=Mann SS, Hammarback JA |title=Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11492-7 |year= 1994 |pmid= 7908909 |doi=  }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
*{{cite journal  | author=Mann SS, Hammarback JA |title=Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B. |journal=J. Neurosci. Res. |volume=43 |issue= 5 |pages= 535-44 |year= 1997 |pmid= 8833088 |doi= 10.1002/(SICI)1097-4547(19960301)43:5&lt;535::AID-JNR3&gt;3.0.CO;2-J }}
*{{cite journal   |vauthors=Bonnet C, Boucher D, Lazereg S, etal |title=Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12839–48 |year= 2001 |pmid= 11278895 |doi= 10.1074/jbc.M011380200 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Bonnet C, Boucher D, Lazereg S, ''et al.'' |title=Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12839-48 |year= 2001 |pmid= 11278895 |doi= 10.1074/jbc.M011380200 }}
*{{cite journal   |vauthors=He H, Dang Y, Dai F, etal |title=Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29278–87 |year= 2003 |pmid= 12740394 |doi= 10.1074/jbc.M303800200 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal   |vauthors=Tanida I, Sou YS, Ezaki J, etal |title=HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36268–76 |year= 2004 |pmid= 15187094 |doi= 10.1074/jbc.M401461200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Kouno T, Mizuguchi M, Tanida I, etal |title=1H, 13C, and 15N resonance assignments of human microtubule-associated protein light chain-3 |journal=J. Biomol. NMR |volume=29 |issue= 3 |pages= 415–6 |year= 2005 |pmid= 15213446 |doi= 10.1023/B:JNMR.0000032505.99071.ea }}
*{{cite journal | author=He H, Dang Y, Dai F, ''et al.'' |title=Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29278-87 |year= 2003 |pmid= 12740394 |doi= 10.1074/jbc.M303800200 }}
*{{cite journal   |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal | author=Tanida I, Sou YS, Ezaki J, ''et al.'' |title=HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36268-76 |year= 2004 |pmid= 15187094 |doi= 10.1074/jbc.M401461200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Kouno T, Mizuguchi M, Tanida I, ''et al.'' |title=1H, 13C, and 15N resonance assignments of human microtubule-associated protein light chain-3. |journal=J. Biomol. NMR |volume=29 |issue= 3 |pages= 415-6 |year= 2005 |pmid= 15213446 |doi= 10.1023/B:JNMR.0000032505.99071.ea }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 }}
*{{cite journal | author=Goehler H, Lalowski M, Stelzl U, ''et al.'' |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853-65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal   |vauthors=Kouno T, Mizuguchi M, Tanida I, etal |title=Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 24610–7 |year= 2005 |pmid= 15857831 |doi= 10.1074/jbc.M413565200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Sou YS, Tanida I, Komatsu M, etal |title=Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16 |journal=J. Biol. Chem. |volume=281 |issue= 6 |pages= 3017–24 |year= 2006 |pmid= 16303767 |doi= 10.1074/jbc.M505888200 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Kouno T, Mizuguchi M, Tanida I, ''et al.'' |title=Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 24610-7 |year= 2005 |pmid= 15857831 |doi= 10.1074/jbc.M413565200 }}
*{{cite journal | author=Sou YS, Tanida I, Komatsu M, ''et al.'' |title=Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. |journal=J. Biol. Chem. |volume=281 |issue= 6 |pages= 3017-24 |year= 2006 |pmid= 16303767 |doi= 10.1074/jbc.M505888200 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
}}
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Latest revision as of 20:16, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene.[1][2][3] Two transcript variants encoding different isoforms have been found for this gene.

Function

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B.[3]

MAPLC3A is one of the mammalian homologues of yeast ATG8, an important marker and effector of autophagy.[4]

Regulation

MAP1LC3A is regulated by several post-translational modifications. These include covalent linkage of the C-terminus to phosphatidylethanolamine in autophagic membranes, and phosphorylation by protein kinase A,[5] which downregulates its autophagy functions. Noncovalent interactions are important for its cargo targeting functions in selective autophagy. For example, it has been shown to interact with sequestosome 1.[6]

References

  1. ↑ Mann SS, Hammarback JA (May 1997). "Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B". J Neurosci Res. 43 (5): 535–44. doi:10.1002/(SICI)1097-4547(19960301)43:5<535::AID-JNR3>3.0.CO;2-J. PMID 8833088.
  2. ↑ Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T (Aug 2007). "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy". J Biol Chem. 282 (33): 24131–45. doi:10.1074/jbc.M702824200. PMID 17580304.
  3. ↑ 3.0 3.1 "Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha".
  4. ↑ Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, Alabiso O, Arisio R, Katsaros D, Benedetto C, Isidoro C (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". Biomed Res Int. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242. PMID 25136588.
  5. ↑ Cherra SJ, Kulich SM, Uechi G, Balasubramani M, Mountzouris J, Day BW, Chu CT (August 2010). "Regulation of the autophagy protein LC3 by phosphorylation". J. Cell Biol. 190 (4): 533–9. doi:10.1083/jcb.201002108. PMC 2928022. PMID 20713600.
  6. ↑ Shvets E, Fass E, Scherz-Shouval R, Elazar Z (August 2008). "The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes". J. Cell Sci. 121 (Pt 16): 2685–95. doi:10.1242/jcs.026005. PMID 18653543.

Further reading


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