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===Echocardiography or Ultrasound===
===Echocardiography or Ultrasound===
On ultrasound, neuroblastoma is characterized by a heterogeneous [[echogenicity]] due to the [[vascular]], [[necrotic]], and calcified content of the mass.<ref name="radio">Neuroblastoma. Radiopaedia (2015) http://radiopaedia.org/articles/neuroblastoma Accessed on October, 8 2015</ref>
Ultrasound in the neuroblastoma shows heterogeneous solid masses due to vascular, necrotic and calcified content of the masses. When it is present in the adrenal, it displaces the kidneys inferiorly.


===Other Imaging Findings===
===Other Imaging Findings===

Revision as of 17:14, 28 February 2019

Neuroblastoma Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Neuroblastoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Neuroblastoma is a malignant tumor that arises from neural crest cells, which are normally involved in the development of the sympathetic nervous system and adrenal glands.[1][2][3][4] In 1910, the term neuroblastoma was first used to describe the tumor by Dr. James Homer Wright, an American patholgist at Massachusetts General Hospital. Based on the degree of the cellular maturity and composition, neuroblastoma may be further classified into three subtypes according to the International Neuroblastoma Pathology Classification which include undifferentiated neruoblastoma, poorly differentiated neuroblastoma, and differentiating neuroblastoma.[5][6] Genes involved in the pathogenesis of neuroblastoma include NBPF10 gene, KIF1B gene, and ALK gene. Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy. The staging of neuroblastoma is based on the International Neuroblastoma Staging System (INSS).[7][8] Symptoms of neuroblastoma include fever, abdominal distension, constipation, cough, and weakness. A positive finding of a palpable abdominal mass, fever, and purple skin patches is suggestive of neuroblastoma. On labrotary studies an elevated levels of blood and urinary catecholamines, vanillylmandelic acid (VMA), and homovanillic acid (HVA) are suggestive of neuroblastoma. CT scan is the investigation of choice for the diagnosis of neuroblastoma.[8] On CT scan, neuroblastoma is characterized by a heterogeneous, calcified, and necrotic mass, that may encase surrounding vessels or invade surrounding tissues. The definitive diagnosis of nueroblastoma is confirmed by a biopsy. Children Oncology Group (COG) risk stratification system determines the protocol of management used for neuroblastoma patients. Low risk neuroblastoma patients are usually managed with either observation or surgical resection of the tumor. Intermidiate risk neuroblastoma patients are usually managed with neoadjuvant chemotherapy in advance of a definitive surgical resection. Whereas high risk neuroblastoma patients are usually managed with a combination of surgery, chemotherapy, radiation therapy, hematopoietic stem cell transplantation, differentiation therapy, and immunotherapy. Surgical intervention alone may be curative as a single therapeutic modality for the management of low risk neuroblastoma patients.[1][2][3][4]

Historical Perspective

Neuroblastoma was first described by Rudolf Virchow in 1864 as an abdominal tumor in a child as "glioma". Felix Marchand described characteristics of tumors from adrenal medulla and sympathetic nervous system in 1891. James Homer wright in 1910, described circular clumps of bone marrow ( now named "Homer-Wright pseudorosettes) and advanced the understanding that tumor originated from primitive neural cells and could metastasize to bone.

Classification

International neuroblastoma pathology classification system is used for the classification of neuroblastic tumors. It is subdivided in 02 main categories based on the morphologic features of neuroblastic tumors into; schwannian stroma-poor and schwannian stroma-rich/dominant.

Pathophysiology

Neuroblastoma arises from the neural crest cells, which are normally involved in development of sympathetic nervous system and adrenal glands. It is frequently located along the sympathetic nervous system structures including; adrenal glands, retroperitoneal organs, organ of zuckerkandl, paravertebral sympathetic chain and posterior mediastinum among others. Neuroblastoma tumor cells secrete catecholamine by products including vanillylmandelic acid (VMA) and homovanillic acid (HVA) and vasoactive intestinal polypeptide (VIP) hormone as well. It can metastasize to bone, liver, lungs and brain. The various genes involved in pathogenesis of neuroblastoma include; NBPF10, KIF1B, ALK, LMO1 and PHOX2A genes. The most common genetic mutation is gain of chromosome 17q and MYCN oncogene amplification predicts more aggressive neuroblastoma. Neuroblastoma can also be associated with a number of syndromes including; neurofibromatosis type 1, beckwith-weidman syndrome and hirschsprung disease. On gross pathology, the characteristic finding of neuroblastoma is a well defined, bulky and tan colored mass, that can be associated with fibrous pseudocapsule, necrosis or hemorrhage. On microscopic picture, the presence of round blue cells separated by thin fibrous septa are a characteristic finding.

Causes

There are no known established causes for neuroblastoma.

Differentiating Multiple Myeloma from other Diseases

Intra-abdominal neuroblastoma must be differentiated from other diseases that cause abdominal distension and constipation such as Wilms tumor and ganglioneuroma. Intra-thoracic neuroblastoma must be differentiated from other diseases that cause shortness of breath and chronic cough such as intrathoracic lymphoma and extra lobar pulmonary sequestration.

Epidemiology and Demographics

Neuroblastoma is the most common solid extracranial cancer in childhood and is the most common cancer in infancy. The overall incidence is 4.9 per 1,000,000 individuals in united states. Males are slightly more affected than females with 1.2:1 ratio. Neuroblastoma usually affects individuals of the caucasian race.

Risk Factors

The risk factors for neuroblastomas diagnosed during infancy include; maternal anemia during pregnancy, neonatal respiratory distress syndrome and low 1 minute Apgar score. However, the risk factors for neuroblastoma cases diagnosed at age 1 year or above is not known.

Screening

There is insufficient evidence to recommend the routine screening for neuroblastoma as it has no mortality benefits.

Natural History, Complications and Prognosis

Neuroblastoma may progress to develop fatigue, loss of appetite, joint pain and fever if left untreated. There is gradual development of site specific symptoms as the tumor size gradually increases. Complications of neuroblastoma include; persistent refractory diarrhea, horner's syndrome, hypertension, transverse myelopathy, anemia and suppressed immunity. The prognosis of neuroblastoma is generally regarded as poor, depending on the tumor extent at the time of diagnosis. The other prognostic factors for nuroblastoma include; patient's age, tumor stage and grade, genetic mutations and response to treatment.

Diagnosis

Staging

According to the conventional International Neuroblastoma Staging System (INSS), there are 6 stages of neuroblastoma based on the tumor size, lymph node involvement, and presence of metastesis. However, according to a newly proposed International Neuroblastoma Risk Group Staging System (INRGSS), there are four stages of neuroblastoma based on the extent of dissemination and image findings. Neuroblastoma patients are risk stratified according to the Children Oncology Group (COG) risk stratification system into a low risk group, an intermediate risk group, and a high risk group based on the tumor INSS stage, the patient's age, tumor grade, and the amplification of MYCN gene.

History and Symptoms

A detailed history of presenting symptoms, family history and other associated symptoms should be undertaken when evaluating a patient of neuroblastoma. General neuroblastoma symptoms include; fever, irritability, fatigue, loss of appetite and weight loss. Other symptoms depending upon the anatomical location of neuroblastoma include; abdominal pain, distension and constipation (abdomen), shortness of breath, chronic cough & difficulty swallowing (posterior mediastinum), weakness, numbness, paralysis (retroperitoneum), visual defects, facial bruising (head & neck) and pallor, bone pain (bone marrow metastases).

Physical Examination

Physical examination findings of neuroblastoma include; fever, hypertension, tachycardia, pallor, ecchymoses, nystagmus, proptosis, ptosis, abdominal mass, brisk reflexes, sensory loss and ataxia.

Laboratory Findings

The laboratory findings in neuroblastoma include; ↓ hemoglobin, ↑ ferritin, ↑ catecholamine, ↑ dopamine, ↑ vanillylmandelic acid (VMA), ↑ homovanillic acid (HVA), ↑ lactate dehydrogenase and ↑ neuron-specific enolase levels. There are increased urinary catecholamine, vanillylmandelic acid (VMA) and homovanillic acid (HVA) levels.

X Ray

X ray findings of neuroblastoma include; intrathoracic or intraabdominal soft tissue mass, calcification, remodeling of surrounding ribs & vertebral bodies, thinning of surrounding pedicles and ill defined, metaphyseal, lucent bone lesions seen in metastases.

CT

CT scan of the neck, chest and abdomen is the gold standard test in neuroblastoma as it can localize the tumor and determine degree of involvement as well. CT scan in neuroblastoma can show the presence of; heterogeneous mass, clacification, necrosis, compression of surrounding vessels, invasion of psoas muscle & kidneys and swollen lymph nodes.

MRI

MRI is considered the most useful modality in staging of neuroblastoma. It is superior to CT scan when determining marrow infiltration and intra spinal tumor extension.MRI findings in neuroblastoma patients include; hypointense heterogeneous mass on T1 weighted image, heterogeneous/hyperintense enhancement due to necrosis and cyst formation seen on T2 weighted images.

Echocardiography or Ultrasound

Ultrasound in the neuroblastoma shows heterogeneous solid masses due to vascular, necrotic and calcified content of the masses. When it is present in the adrenal, it displaces the kidneys inferiorly.

Other Imaging Findings

Other imaging studies for neuroblastoma include nuclear medicine studies such as fludeoxyglucose-18F positron emission tomography scan (18F-FDG PET) and metaiodobenzylguanidine (123I-MIBG) scintigraphy.[9]

Other Diagnostic Studies

The definitive diagnosis of nueroblastoma is confirmed by a biopsy. Charecterstic findings for neuroblastoma on microscopic histopathological analysis can be found here.[2]

Treatment

Medical Therapy

Children Oncology Group (COG) risk stratification system determines the protocol of management used for neuroblastoma patients. Low risk neuroblastoma patients are usually managed with either observation or surgical resection of the tumor. Intermidiate risk neuroblastoma patients are usually managed by 4-8 cycles of chemotherapy following surgical resection. Whereas high risk neuroblastoma patients are usually managed with a combination of surgery, chemotherapy, radiation therapy, hematopoietic stem cell transplantation, differentiation therapy, and immunotherapy.[4]

Surgery

Surgical intervention alone may be curative as a single therapeutic modality for the management of low risk neuroblastoma patients.[4]

References

  1. 1.0 1.1 Neuroblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Neuroblastoma Accessed on October, 4 2015
  2. 2.0 2.1 2.2 Neuroblastoma. Libre Pathology(2015) http://librepathology.org/wiki/index.php/Adrenal_gland#Neuroblastoma Accessed on October, 5 2015
  3. 3.0 3.1 Neuroblastoma. Radiopaedia(2015) http://radiopaedia.org/articles/neuroblastoma Accessed on October, 5 2015
  4. 4.0 4.1 4.2 4.3 Neuroblastoma Treatment for health professionals. National Cancer Institute (2015) http://www.cancer.gov/types/neuroblastoma/hp/neuroblastoma-treatment-pdq#link/_534_toc Accessed on October, 7 2015
  5. Neuroblastoma, Ganglioneuroblastoma and Ganglioneuroma. Stanford Medicine Surgical Pathology Criteria(2015) http://surgpathcriteria.stanford.edu/srbc/neuroblastoma-ganglioneuroblastoma-ganglioneuroma/ Accessed on October, 5 2015
  6. Shimada H, Umehara S, Monobe Y, Hachitanda Y, Nakagawa A, Goto S; et al. (2001). "International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group". Cancer. 92 (9): 2451–61. PMID 11745303.
  7. Davidoff AM (2012). "Neuroblastoma". Semin Pediatr Surg. 21 (1): 2–14. doi:10.1053/j.sempedsurg.2011.10.009. PMC 3261589. PMID 22248965.
  8. 8.0 8.1 Colon NC, Chung DH (2011). "Neuroblastoma". Adv Pediatr. 58 (1): 297–311. doi:10.1016/j.yapd.2011.03.011. PMC 3668791. PMID 21736987.
  9. Sharp SE, Shulkin BL, Gelfand MJ, Salisbury S, Furman WL (2009). "123I-MIBG scintigraphy and 18F-FDG PET in neuroblastoma". J Nucl Med. 50 (8): 1237–43. doi:10.2967/jnumed.108.060467. PMID 19617326.


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