Alzheimer's disease pathophysiology: Difference between revisions
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==Pathogenesis== | ==Pathogenesis== | ||
Alzheimer disease (AD), is a progressive neurodegenerative disorder. The dysfunction of amyloid precursor protien (APP) metabolism and the resulting build up of of Aβ peptides and their aggregation in the form of senile plaques in the brain parenchyma of individuals have been considered pivotal for neurodegeneration in the disease. There is also an accumulation of intracellular neurofibrillary tangles that consist of hyperphosphorylated tau protein and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus, and the neocortex. | Alzheimer disease (AD), is a progressive neurodegenerative disorder. The dysfunction of amyloid precursor protien (APP) metabolism and the resulting build up of of Aβ peptides and their aggregation in the form of senile plaques in the brain parenchyma of individuals have been considered pivotal for neurodegeneration in the disease. There is also an accumulation of intracellular neurofibrillary tangles that consist of hyperphosphorylated tau protein and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus, and the neocortex. | ||
* The pathogenesis of Alzheimer's dementia (AD) can be explained by three pathological processes. The processes inloved in the | * The pathogenesis of Alzheimer's dementia (AD) can be explained by three pathological processes. The processes inloved in the development of AD and their molecular basis is as follows: | ||
=== (i) Neuronal loss === | |||
=== (ii) Aggregation of amyloid β (Aβ) === | |||
* Amyloid precurosr protein (APP) is physiologically present in normal brains | |||
* It is proteolytically processed by α-, β-, and γ-secretases following two pathways: | |||
'''Constitutive (nonamyloidogenic) pathway''' | |||
In the constitutive pathway, proteolysis of APP by α- and γ-secretases results in nonpathogenic fragments (sAPPα and α-C-terminal fragment) | |||
'''Amyloidogenic pathway''' | |||
=== (iii | In the amyloidogenic pathway, proteolysis of APP by β-secretase and γ-secretase gives rise to a mixture of Aβ peptides with different lengths. There are two major Aβ species: Aβ1–40 (90%) and Aβ1–42 (10%). The Aβ1–42 fragments are more aggregation-prone and are predominantly present in amyloid plaques in brains of AD patients. | ||
=== (iii) Formation of intraneuronal neurofibrillary tangles === | |||
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Revision as of 17:56, 17 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Risk calculators and risk factors for Alzheimer's disease pathophysiology |
Overview
Pathogenesis
Alzheimer disease (AD), is a progressive neurodegenerative disorder. The dysfunction of amyloid precursor protien (APP) metabolism and the resulting build up of of Aβ peptides and their aggregation in the form of senile plaques in the brain parenchyma of individuals have been considered pivotal for neurodegeneration in the disease. There is also an accumulation of intracellular neurofibrillary tangles that consist of hyperphosphorylated tau protein and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus, and the neocortex.
- The pathogenesis of Alzheimer's dementia (AD) can be explained by three pathological processes. The processes inloved in the development of AD and their molecular basis is as follows:
(i) Neuronal loss
(ii) Aggregation of amyloid β (Aβ)
- Amyloid precurosr protein (APP) is physiologically present in normal brains
- It is proteolytically processed by α-, β-, and γ-secretases following two pathways:
Constitutive (nonamyloidogenic) pathway
In the constitutive pathway, proteolysis of APP by α- and γ-secretases results in nonpathogenic fragments (sAPPα and α-C-terminal fragment)
Amyloidogenic pathway
In the amyloidogenic pathway, proteolysis of APP by β-secretase and γ-secretase gives rise to a mixture of Aβ peptides with different lengths. There are two major Aβ species: Aβ1–40 (90%) and Aβ1–42 (10%). The Aβ1–42 fragments are more aggregation-prone and are predominantly present in amyloid plaques in brains of AD patients.
(iii) Formation of intraneuronal neurofibrillary tangles
Triggers
The following factors lead to the development of Alzheimer's dementia:
- Genetic factors
- Environmental factors
- Chromosomal factors
Genetic Factors
Genetic origin of Alzheimer's dementia (AD) demonstrates an autosomal dominant pattern of inheritance. Alzheimer's dementia arising from genetic alterations may lead to early onset (<60 years) of disease. The following mutations are implicated in the development of AD are:
Early onset (Alzheimer's dementia-AD 1, 3 and 4)
30-50 percent of early-onset Alzheimer's dementia (AD) is associated with an autosomal dominant inheritance and consists of mutations in the following genes:
- Presenilin1 (PS1) gene, also called PSEN1 gene on chromosome 14 (AD3- 20 to 30 percent cases)
- Presenilin 2 (PS2) gene, also called PSEN2 gene on chromosome 1 (AD4- rare)
- Point mutations in amyloid beta A4 protein gene, also called amyloid precursor protein (APP) gene on chromosome 21 are associated in some cases of early onset (< 65 yr) familial AD cases
Late onset (Alzheimer's dementia -AD2)
- Apolipoprotein 4 gene (APOE4) mutation is associated with late onset (>60 years) Alzheimer's dementia (AD)
- p.Arg47His allelic variant in TREM2 gene
Hypotheses for Alzheimer's dementia
Two major hypothses for the development of Alzheimer's dementia (AD) have been proposed:
Amyloid cascade hypothesis