Human parainfluenza virus: Difference between revisions

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*Human parainfluenza viruses (HPIVs) are a group of four [[serotypes]] of enveloped, single stranded negative sense [[RNA]] viruses.<ref name = "ParaChar">{{cite journal |vauthors=Vainionpää R, Hyypiä T |title=Biology of parainfluenza viruses |journal=Clin. Microbiol. Rev. |volume=7 |issue=2 |pages=265–75 |year=1994 |pmid=8055470 |pmc=358320 |doi= |url=}}</ref>
*Human parainfluenza viruses (HPIVs) are a group of four [[serotypes]] of enveloped, single stranded negative sense [[RNA]] viruses.<ref name = "ParaChar">{{cite journal |vauthors=Vainionpää R, Hyypiä T |title=Biology of parainfluenza viruses |journal=Clin. Microbiol. Rev. |volume=7 |issue=2 |pages=265–75 |year=1994 |pmid=8055470 |pmc=358320 |doi= |url=}}</ref>
*The human parainfluenza virus [[genome]] consists of approximately 15,000 [[nucleotides]] used to encode the following six structural proteins:.<ref name="Henrickson2003">{{cite journal|last1=Henrickson|first1=K. J.|title=Parainfluenza Viruses|journal=Clinical Microbiology Reviews|volume=16|issue=2|year=2003|pages=242–264|issn=0893-8512|doi=10.1128/CMR.16.2.242-264.2003}}</ref>
*The human parainfluenza virus [[genome]] consists of approximately 15,000 [[nucleotides]] used to encode the following six structural proteins:.<ref name="Henrickson2003">{{cite journal|last1=Henrickson|first1=K. J.|title=Parainfluenza Viruses|journal=Clinical Microbiology Reviews|volume=16|issue=2|year=2003|pages=242–264|issn=0893-8512|doi=10.1128/CMR.16.2.242-264.2003}}</ref>
**[[Hemagglutinin|hemagglutinin]]-[[Neuraminidase|neuraminidase]]
 
**[[Fusion protein|fusion protein]]
 
**[[Matrix protein|matrix protein]]
{| style="font-size: 85%;"
**[[Nucleoprotein|nucleoprotein]]
! style="width: 110px; background: #4479BA; text-align: center;" | {{fontcolor|#FFF|Protein}}
**[[Phosphoprotein|phosphoprotein]]
! style="width: 110px; background: #4479BA; text-align: center;" | {{fontcolor|#FFF|Location}}
**[[RNA polymerase|large protein]]
! style="width: 300px; background: #4479BA; text-align: center;" | {{fontcolor|#FFF|Function}}
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" | '''[[Hemagglutinin|hemagglutinin]]'''
| style="background: #F5F5F5; padding: 5px;" | Envelope
| style="background: #F5F5F5; padding: 5px;" | Attachment and cell entry
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" | '''[[Fusion protein|fusion protein]]'''
| style="background: #F5F5F5; padding: 5px;" | Envelope
| style="background: #F5F5F5; padding: 5px;" | Fusion and cell entry
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" | '''[[Matrix protein|matrix protein]]'''
| style="background: #F5F5F5; padding: 5px;" | Within the envelope
| style="background: #F5F5F5; padding: 5px;" | Assembly
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" | '''[[Nucleoprotein|nucleoprotein]]'''
| style="background: #F5F5F5; padding: 5px;" | [[Nucleocapsid]]
| style="background: #F5F5F5; padding: 5px;" | Forms a complex with the [[RNA]] [[Genome|genome]]
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" | '''[[Phosphoprotein|phosphoprotein]]'''
| style="background: #F5F5F5; padding: 5px;" | [[Nucleocapsid]]
| style="background: #F5F5F5; padding: 5px;" | Forms as a part of the [[RNA polymerase]] complex
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" | '''[[RNA polymerase|large protein]]'''
| style="background: #F5F5F5; padding: 5px;" | [[Nucleocapsid]]
| style="background: #F5F5F5; padding: 5px;" | Forms as a part of the [[RNA polymerase]] complex
|}


==References==
==References==

Revision as of 17:23, 27 January 2016

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Human parainfluenza virus
A Transmission Electron Micrograph (TEM) depicting parainfluenza virions, and free filamentous nucleocapsid material.
A Transmission Electron Micrograph (TEM) depicting parainfluenza virions, and free filamentous nucleocapsid material.
Virus classification
Group: Group V ((-)ssRNA)
Family: Paramyxoviridae
Genus: Respirovirus & Rubulavirus
This page is about microbiologic aspects of the organism(s).  For clinical aspects of the disease, see Croup.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.

Overview

Microbiological Characteristics

  • Human parainfluenza viruses (HPIVs) are a group of four serotypes of enveloped, single stranded negative sense RNA viruses.[1]
  • The human parainfluenza virus genome consists of approximately 15,000 nucleotides used to encode the following six structural proteins:.[2]


Protein Location Function
hemagglutinin Envelope Attachment and cell entry
fusion protein Envelope Fusion and cell entry
matrix protein Within the envelope Assembly
nucleoprotein Nucleocapsid Forms a complex with the RNA genome
phosphoprotein Nucleocapsid Forms as a part of the RNA polymerase complex
large protein Nucleocapsid Forms as a part of the RNA polymerase complex

References

  1. Vainionpää R, Hyypiä T (1994). "Biology of parainfluenza viruses". Clin. Microbiol. Rev. 7 (2): 265–75. PMC 358320. PMID 8055470.
  2. Henrickson, K. J. (2003). "Parainfluenza Viruses". Clinical Microbiology Reviews. 16 (2): 242–264. doi:10.1128/CMR.16.2.242-264.2003. ISSN 0893-8512.


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