Sporotrichosis pathophysiology: Difference between revisions

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* Disseminated cutaneous form
* Disseminated cutaneous form
** Manifests upon the hematogenous dissemination of the yeast form of ''S. schenckii''.
** Manifests upon the hematogenous dissemination of the yeast form of ''S. schenckii''.
Extracutaneous/Systematic Forms
*Osteoarticular form
**May manifest upon contiguity or hematogenous spread.
*Pulmonary form
*Disseminated form


==References==
==References==

Revision as of 18:02, 13 January 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Alison Leibowitz [2]

Overview

Pathophysiology

Transmission

  • S. schenckii is usually transmitted to the human host via posttraumatic inoculation. However, sporotrichosis may also develop as a result of spore inhalation, although this mode of transmission is infrequent.
  • Modes of transmission either lead to direct inoculation or enable the entry of the fungus.
  • Actions, such as handling thorny plants, sphagnum moss, bales of hay, or any plant or plant product that can cause skin trauma, may enable S. schenckii entry.

Pathogenesis

  • The pathophysiology of sporotrichosis depends on the histological subtype and the frequently nonspecific histopathology may mimic other granulomatous diseases.[1]

Cutaneous forms

  • S. schecknii accesses the subcutaneous tissue following minor epidermal trauma.
  • S. schecknii, a thermo-dependent fungus, converts into its yeast form upon entering the tissue.
  • Fixed form
    • The yeast form of S. schenckii stays localized in subcutaneous tissue
  • Lymphocutaneous form
    • The yeast form of S. schenckii extends through the nearby lymphatic vessels
  • Disseminated cutaneous form
    • Manifests upon the hematogenous dissemination of the yeast form of S. schenckii.

Extracutaneous/Systematic Forms

  • Osteoarticular form
    • May manifest upon contiguity or hematogenous spread.
  • Pulmonary form
  • Disseminated form

References

  1. Mahajan VK (2014). "Sporotrichosis: an overview and therapeutic options". Dermatol Res Pract. 2014: 272376. doi:10.1155/2014/272376. PMC 4295339. PMID 25614735.