Glioblastoma multiforme MRI: Difference between revisions
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==MRI== | ==MRI== | ||
Brain MRI is helpful in the diagnosis of glioblastoma. On brain MRI, glioblastoma is characterized by:<ref name=ddd>XYZ of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | |||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|MRI component}} | |||
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Features}} | |||
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:T1 | |||
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*Hypo to isointense mass within [[white matter]] | |||
*Central heterogenous signal ([[necrosis]], intratumoral [[hemorrhage]]) | |||
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:T1 C+ (Gd) | |||
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*Enhancement is variable | |||
*Typically peripheral and irregular with nodular components | |||
*Usually completely surrounds [[necrosis]] | |||
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:T2/FLAIR | |||
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*Hyperintense | |||
*Surrounded by vasogenic [[edema]] | |||
*Flow voids observed | |||
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:GE/SWI | |||
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*Susceptibility artifact on T2 from blood products (or occasionally calcification) | |||
*Low intensity rim from blood product | |||
*Located inside the peripheral enhancing component | |||
*Absent dual rim sign | |||
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:DWI/ADC | |||
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*Solid component | |||
**Elevated signal on DWI is common in solid / enhancing component | |||
**Diffusion restriction is typically intermediate similar to normal [[white matter]], but significantly elevated compared to surrounding vasogenic [[edema]] (which has facilitated diffusion) | |||
*ADC values correlate with grade: | |||
**WHO IV (GBM) = 745 ± 135 x 10-6 mm2/s | |||
**WHO III (anaplastic) = 1067 ± 276 x 10-6 mm2/s | |||
**WHO II (low grade) = 1273 ± 293 x 10-6 mm2/s | |||
**ADC threshold value of 1185 x 10-6 mm2/s sensitivity (97.6%) and specificity (53.1%) in the discrimination of high-grade (WHO grade III & IV) and low-grade (WHO grade II) gliomas | |||
*Non-enhancing necrotic / cystic component | |||
**Majority (>90%) have facilitated diffusion (ADC values > 1000 x 10-6 mm2/s) | |||
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:MR perfusion | |||
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*rCBV elevated compared to lower grade [[tumors]] and normal [[brain]] | |||
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:MR spectroscopy | |||
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*Choline: increased | |||
*Lactate: increased | |||
*Lipids: increased | |||
*NAA: decreased | |||
*Myo-inositol: decreased | |||
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Revision as of 13:53, 15 September 2015
Glioblastoma multiforme Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Glioblastoma multiforme MRI On the Web |
American Roentgen Ray Society Images of Glioblastoma multiforme MRI |
Risk calculators and risk factors for Glioblastoma multiforme MRI |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
MRI
Brain MRI is helpful in the diagnosis of glioblastoma. On brain MRI, glioblastoma is characterized by:[1]
MRI component | Features |
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*Solid component
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Patient #1: Presented with increasing headaches
Patient #2
References
- ↑ XYZ of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma