5-alpha-reductase deficiency pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
The [[5-alpha reductase]] [[enzyme]] is responsible for converting [[testosterone]] to [[dihydrotestosterone]] (DHT) which is a more potent form playing major roles in [[male]] [[sexual development]]. | |||
While [[Testosterone]] leads the development of [[internal]] [[male genitalia]], [[DHT]] develops the external [[male genitalia]]. Children with [[5-alpha reductase]] [[deficiency]] suffers from defective [[external genitalia]] and [[ambiguous genitalia]]. | |||
==Pathophysiology== | |||
'''[[5-alpha-reductase]]''' is an [[enzyme]] that converts [[testosterone]] to [[dihydrotestosterone]] (DHT) in peripheral tissues. 5-alpha-reductase deficiency-2 is biochemically characterized by low to low normal levels of testosterone and decreased levels of 5α-DHT, creating a higher testosterone/DHT ratio. | |||
[[Image:Test biosynth 5ARD2.jpg|thumb|center|680px| Biochemical effects of 5-alpha-reductase deficiency-2 in testosterone biosynthesis. Typically levels of testosterone are elevated, while levels of DHT are significantly decreased, leading to male [[undervirilization]].]] | |||
DHT is a potent [[androgen]], necessary for the development of male external [[genitalia]] in utero. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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{{WS}} | {{WS}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Endocrinology | [[Category:Endocrinology]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
Latest revision as of 21:35, 23 December 2021
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5-alpha-reductase deficiency Microchapters |
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Differentiating 5-alpha-reductase deficiency from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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5-alpha-reductase deficiency pathophysiology On the Web |
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American Roentgen Ray Society Images of 5-alpha-reductase deficiency pathophysiology |
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Directions to Hospitals Treating 5-alpha-reductase deficiency |
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Risk calculators and risk factors for 5-alpha-reductase deficiency pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The 5-alpha reductase enzyme is responsible for converting testosterone to dihydrotestosterone (DHT) which is a more potent form playing major roles in male sexual development. While Testosterone leads the development of internal male genitalia, DHT develops the external male genitalia. Children with 5-alpha reductase deficiency suffers from defective external genitalia and ambiguous genitalia.
Pathophysiology
5-alpha-reductase is an enzyme that converts testosterone to dihydrotestosterone (DHT) in peripheral tissues. 5-alpha-reductase deficiency-2 is biochemically characterized by low to low normal levels of testosterone and decreased levels of 5α-DHT, creating a higher testosterone/DHT ratio.
DHT is a potent androgen, necessary for the development of male external genitalia in utero.