SLC5A3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Sodium/myo-inositol cotransporter''' is a [[protein]] that in humans is encoded by the ''SLC5A3'' [[gene]].<ref name="pmid7789985">{{cite journal | vauthors = Berry GT, Mallee JJ, Kwon HM, Rim JS, Mulla WR, Muenke M, Spinner NB | title = The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21 | journal = Genomics | volume = 25 | issue = 2 | pages = 507–13 |date=Jul 1995 | pmid = 7789985 | pmc =  | doi =10.1016/0888-7543(95)80052-N  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC5A3 solute carrier family 5 (inositol transporters), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6526| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
Expression of the myo-inositol transport protein is regulated by [[NFAT5#Osmotic stress|osmotic stress]].<ref>{{Cite journal
{{GNF_Protein_box
| vauthors = Lee SD, Choi SY, Lim SW, Lamitina ST, Ho SN, Go WY, Kwon HM
| image =
| doi = 10.1152/ajprenal.00227.2010
| image_source = 
| title = TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and -independent pathways
| PDB =
| journal = AJP: Renal Physiology
| Name = Solute carrier family 5 (inositol transporters), member 3
| volume = 300
| HGNCid = 11038
| issue = 3
| Symbol = SLC5A3
| pages = F707–F715
| AltSymbols =; SMIT; SMIT2
| year = 2011
| OMIM = 600444
| pmid = 21209002
| ECnumber = 
| pmc =3064130
| Homologene = 31412
}}</ref>
| MGIid = 1858226
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005367 |text = myo-inositol:sodium symporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6526
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_008864
    | Hs_RefseqmRNA = NM_006933
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 53881
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_017391
    | Mm_RefseqProtein = NP_059087
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr =
    | Mm_GenLoc_start =
    | Mm_GenLoc_end =
    | Mm_Uniprot =
  }}
}}
 
 
 
'''Solute carrier family 5 (inositol transporters), member 3''', also known as '''SLC5A3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC5A3 solute carrier family 5 (inositol transporters), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6526| accessdate = }}</ref>
 
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| summary_text =
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==See also==
==See also==
Line 64: Line 23:
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Kwon HM, Yamauchi A, Uchida S, etal |title=Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 6297–301 |year= 1992 |pmid= 1372904 |doi=  }}
| citations =
*{{cite journal  | vauthors=Berry GT, Mallee JJ, Blouin JL, Antonarakis SE |title=The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1–2 |pages= 77–8 |year= 1996 |pmid= 8646889 |doi=10.1159/000134311 }}
*{{cite journal | author=Kwon HM, Yamauchi A, Uchida S, ''et al.'' |title=Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 6297-301 |year= 1992 |pmid= 1372904 |doi=  }}
*{{cite journal   |vauthors=Mallee JJ, Atta MG, Lorica V, etal |title=The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter |journal=Genomics |volume=46 |issue= 3 |pages= 459–65 |year= 1998 |pmid= 9441750 |doi= 10.1006/geno.1997.5055 }}
*{{cite journal  | author=Berry GT, Mallee JJ, Kwon HM, ''et al.'' |title=The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21. |journal=Genomics |volume=25 |issue= 2 |pages= 507-13 |year= 1995 |pmid= 7789985 |doi=  }}
*{{cite journal   |vauthors=Porcellati F, Hlaing T, Togawa M, etal |title=Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts |journal=Am. J. Physiol. |volume=274 |issue= 5 Pt 1 |pages= C1215–25 |year= 1998 |pmid= 9612208 |doi=  }}
*{{cite journal  | author=Berry GT, Mallee JJ, Blouin JL, Antonarakis SE |title=The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 77-8 |year= 1996 |pmid= 8646889 |doi=  }}
*{{cite journal   |vauthors=Rim JS, Atta MG, Dahl SC, etal |title=Transcription of the Sodium/myo-Inositol Cotransporter Gene Is Regulated by Multiple Tonicity-responsive Enhancers Spread over 50 Kilobase Pairs in the 5′-Flanking Region |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20615–21 |year= 1998 |pmid= 9685419 |doi=10.1074/jbc.273.32.20615  | pmc=2365891 }}
*{{cite journal | author=Mallee JJ, Atta MG, Lorica V, ''et al.'' |title=The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter. |journal=Genomics |volume=46 |issue= 3 |pages= 459-65 |year= 1998 |pmid= 9441750 |doi= 10.1006/geno.1997.5055 }}
*{{cite journal   |vauthors=Hattori M, Fujiyama A, Taylor TD, etal |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal | author=Porcellati F, Hlaing T, Togawa M, ''et al.'' |title=Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts. |journal=Am. J. Physiol. |volume=274 |issue= 5 Pt 1 |pages= C1215-25 |year= 1998 |pmid= 9612208 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Rim JS, Atta MG, Dahl SC, ''et al.'' |title=Transcription of the sodium/myo-inositol cotransporter gene is regulated by multiple tonicity-responsive enhancers spread over 50 kilobase pairs in the 5'-flanking region. |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20615-21 |year= 1998 |pmid= 9685419 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
*{{cite journal | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Thangaraju M, Gopal E, Martin PM, etal |title=SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11560–4 |year= 2007 |pmid= 17178845 |doi= 10.1158/0008-5472.CAN-06-1950 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Thangaraju M, Gopal E, Martin PM, ''et al.'' |title=SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11560-4 |year= 2007 |pmid= 17178845 |doi= 10.1158/0008-5472.CAN-06-1950 }}
}}
{{refend}}
{{refend}}


{{Membrane transport proteins}}
{{Solute carrier family|bg|bg0}}
 
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WH}}
 
{{WS}}
 
{{membrane-protein-stub}}

Latest revision as of 06:35, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene.[1][2]

Expression of the myo-inositol transport protein is regulated by osmotic stress.[3]

See also

References

  1. ↑ Berry GT, Mallee JJ, Kwon HM, Rim JS, Mulla WR, Muenke M, Spinner NB (Jul 1995). "The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21". Genomics. 25 (2): 507–13. doi:10.1016/0888-7543(95)80052-N. PMID 7789985.
  2. ↑ "Entrez Gene: SLC5A3 solute carrier family 5 (inositol transporters), member 3".
  3. ↑ Lee SD, Choi SY, Lim SW, Lamitina ST, Ho SN, Go WY, Kwon HM (2011). "TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and -independent pathways". AJP: Renal Physiology. 300 (3): F707–F715. doi:10.1152/ajprenal.00227.2010. PMC 3064130. PMID 21209002.

Further reading


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