T-cell prolymphocytic leukemia natural history, complications and prognosis: Difference between revisions
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{{CMG}}; {{AE}}{{Qurrat}}, {{MV}} | {{CMG}}; {{AE}}{{Qurrat}}, {{MV}} | ||
{{T-cell-prolymphocytic leukemia}} | {{T-cell-prolymphocytic leukemia}} | ||
==Overview== | |||
T-cell prolymphocytic leukemia is diagnosed after its [[Symptom|symptoms]] appear. Failure to treat can result in [[multiple organ failure]]. | |||
== Natural History, Complications and Prognosis== | |||
*The majority of [[Patient|patients]] with T-cell prolymphocytic leukemia are [[symptomatic]] at the time of diagnosis. | |||
*Early clinical features include [[fever]], [[fatigue]], and [[lymphadenopathy]]. | |||
*If left untreated, patients with T-cell prolymphocytic leukemia may progress to develop [[multiple organ failure]]. | |||
*Common complications of T-cell prolymphocytic leukemia, include:<ref name="pmid23382603">{{cite journal |vauthors=Graham RL, Cooper B, Krause JR |title=T-cell prolymphocytic leukemia |journal=Proc (Bayl Univ Med Cent) |volume=26 |issue=1 |pages=19–21 |year=2013 |pmid=23382603 |pmc=3523759 |doi= |url=}}</ref> | |||
:*[[Graft-versus-host disease]] ([[allogeneic]] [[Organ transplant|transplant]]) | |||
:*[[Infection|Infections]] | |||
:*[[Bleeding : Overview|Bleeding]] | |||
*[[Prognosis]] is generally poor, and the median survival time of patients with [[T cell|T-cell]] [[prolymphocytic leukemia]] is approximately one to two years.<ref name="pmid23382603">{{cite journal |vauthors=Graham RL, Cooper B, Krause JR |title=T-cell prolymphocytic leukemia |journal=Proc (Bayl Univ Med Cent) |volume=26 |issue=1 |pages=19–21 |year=2013 |pmid=23382603 |pmc=3523759 |doi= |url=}}</ref> | |||
*[[Patient|Patients]] with CD45RO+/CD45RA- [[immunophenotype]] tend to have a more indolent course. | |||
*It seems following factors are associated with worse [[prognosis]]: | |||
**Increased expression of [[TCL1A|TCL1]] | |||
**Increased activity of the [[serine-threonine kinase]] [[AKT]] | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} |
Latest revision as of 13:09, 4 April 2019
T-cell prolymphocytic leukemia Microchapters |
Differentiating T-cell prolymphocytic leukemia historical perspective from other Diseases |
---|
Diagnosis |
Treatment |
Case Studies |
T-cell prolymphocytic leukemia natural history, complications and prognosis On the Web |
American Roentgen Ray Society Images of T-cell prolymphocytic leukemia natural history, complications and prognosis |
FDA on T-cell prolymphocytic leukemia natural history, complications and prognosis |
CDC on T-cell prolymphocytic leukemia natural history, complications and prognosis |
T-cell prolymphocytic leukemia natural history, complications and prognosis in the news |
Blogs on T-cell prolymphocytic leukemia natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2], Maria Fernanda Villarreal, M.D. [3]
T-cell prolymphocytic leukemia Microchapters |
Differentiating T-cell Prolymphocytic Leukemia from other Diseases |
---|
Diagnosis |
Treatment |
Case Studies |
T-cell prolymphocytic leukemia natural history, complications and prognosis On the Web |
American Roentgen Ray Society Images of T-cell prolymphocytic leukemia natural history, complications and prognosis |
FDA on T-cell prolymphocytic leukemia natural history, complications and prognosis |
CDC on T-cell prolymphocytic leukemia natural history, complications and prognosis |
T-cell prolymphocytic leukemia natural history, complications and prognosis in the news |
Blogs on T-cell prolymphocytic leukemia natural history, complications and prognosis |
Directions to Hospitals Treating T-cell prolymphocytic leukemia |
Overview
T-cell prolymphocytic leukemia is diagnosed after its symptoms appear. Failure to treat can result in multiple organ failure.
Natural History, Complications and Prognosis
- The majority of patients with T-cell prolymphocytic leukemia are symptomatic at the time of diagnosis.
- Early clinical features include fever, fatigue, and lymphadenopathy.
- If left untreated, patients with T-cell prolymphocytic leukemia may progress to develop multiple organ failure.
- Common complications of T-cell prolymphocytic leukemia, include:[1]
- Prognosis is generally poor, and the median survival time of patients with T-cell prolymphocytic leukemia is approximately one to two years.[1]
- Patients with CD45RO+/CD45RA- immunophenotype tend to have a more indolent course.
- It seems following factors are associated with worse prognosis:
- Increased expression of TCL1
- Increased activity of the serine-threonine kinase AKT