Liposarcoma risk factors: Difference between revisions

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==Overview==
==Overview==
Risk factors of liposarcoma includes [[chemical carcinogen]], [[genetic disorders]], [[radiation]] and [[immunodeficiency]]. These increases the risk of liposarcoma in general population.
Common risk factors in the development of liposarcoma include [[chemical]] [[Carcinogen|carcinogens]], [[radiation]], [[immunodeficiency]], [[genetic disorders]], and [[Viral infection|viral infections]].


==Risk factors==
==Risk Factors==
Liposarcoma is associated with a number of risk factors. Few of them are listed below.<ref name=WHO-SOft tissue tumor>{{cite web | title = WHO-Soft tissue tumor | url = http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb5/bb5-classifsofttissue.pdf }}</ref>
Common [[Risk factor|risk factors]] in the development of liposarcoma are:<ref name="WHO-SOft">{{cite web | title = WHO-Soft tissue tumor | url = http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb5/bb5-classifsofttissue.pdf }}</ref><ref name="WHO-SOft">{{cite web | title = WHO-Soft tissue tumor | url = http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb5/bb5-classifsofttissue.pdf }}</ref>


====Chemical carcinogens====
*[[Chemical]] [[Carcinogen|carcinogens]]
*Phenoxyacetic herbicides
**[[Herbicide|Phenoxyacetic herbicides]]
*Chlorophenols
**Chlorophenols
*Dioxin contaminations
**[[Dioxin]] [[contamination]]
**[[Arsenic]]
**[[Thorium dioxide|Thorium dioxide (Thorotrast)]]


====Radiation====
*[[Radiation]]
Post irradiation sarcoma has an incidence of 1%. Risk has been found with adjuvant therapy of [[radiation]] for breast carcinoma. Risk increases with dose and a dose of 50 GY or more of [[radiation]] has been recorded with increased risk of sarcoma. The mean period between exposure to radiation and tumor diagnosis is 10 years.
**Risk is associated with [[adjuvant therapy]] of [[radiation]] for [[breast carcinoma]].  
**Risk increases with [[dose]] and a [[dose]] of 50 GY or more of [[radiation]] has been recorded with increased risk of [[sarcoma]].  
**The [[mean]] period between exposure to [[Radiation therapy|radiation]] and [[tumor]] [[diagnosis]] is 10 years.


====Immunodeficiency====
*[[Immunodeficiency]]
Regional acquired [[immunodeficiency]] is sometimes associated with liposarcoma
**Regional acquired [[immunodeficiency]] is sometimes associated with liposarcoma.


====Genetic susceptibility====
*[[Genetic]] susceptibility
Li-Fraumeni syndrome is associated with liposarcoma
**[[Li-Fraumeni syndrome]]
**[[Neurofibromatosis|Neurofibromatosis (NF1; von Recklinghausen disease)]]
**[[Gardner syndrome|Gardner syndrome (Familial adenomatous polyposis)]]
**[[Retinoblastoma]]
**[[Werner syndrome]]
**[[Basal cell carcinoma|Nevoid basal cell carcinoma (Gorlin syndrome)]]
 
*[[Viral infection|Viral infections]]


==References==
==References==
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Latest revision as of 16:08, 24 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Common risk factors in the development of liposarcoma include chemical carcinogens, radiation, immunodeficiency, genetic disorders, and viral infections.

Risk Factors

Common risk factors in the development of liposarcoma are:[1][1]

References

  1. 1.0 1.1 "WHO-Soft tissue tumor" (PDF).


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