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==Physical examination==
==References==
{{reflist|2}}
{{WH}}
{{WS}}
==References==
{{Reflist|2}}
===Pathophysiology prev===
===Pathophysiology prev===
<div style="-webkit-user-select: none;">
<div style="-webkit-user-select: none;">
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{{CMG}} {{AE}}
{{CMG}} {{AE}}


==Overview==
Meckel
==Meckel==
<gallery>
Image:


Positive-meckels-scan-001.jpg
===Pathophysiology prev===
<div style="-webkit-user-select: none;">
{| class="infobox" style="position: fixed; top: 65%; right: 10px; margin: 0 0 0 0; border: 0; float: right;"
|-
| {{#ev:youtube|https://https://www.youtube.com/watch?v=5szNmKtyBW4|350}}
|-
|}
__NOTOC__
{{Cirrhosis}}
{{CMG}} {{AE}}


</gallery>
== History and Symptoms ==
<gallery>
Image:


Meckel's-diverticulitis-001.jpg
* History should include:
** Appearance of bowel movements
** Travel history
** Associated symptoms
** Immune status
** Woodland exposure
==References==
{{reflist|2}}


Image:
{{WH}}
{{WS}}


Meckel's-diverticulitis-002.jpg
==Other Imaging Findings==
* [[Endoscopy]]
* [[Barium enema]]
* [[Colonoscopy]]
* [[Sigmoidoscopy]]


Image:
==Other diagnostic studies==
== Other Diagnostic Studies ==


Meckel's-diverticulitis-003.jpg
* Breath hydrogen test


Image:
* [[HIV test]]ing for those patients suspected of having HIV


Meckel's-diverticulitis-004.jpg
==


</gallery>
==Overview==


==References==
==References==
{{reflist|2}}
{{reflist|2}}


[[Category:Gastroenterology]]
{{WH}}
[[Category:Hepatology]]
[[Category:Disease]]
 
{{WS}}
{{WS}}
{{WH}}
===the end===
-
==== Portal HTN results from the combination of the following: ====
* Structural disturbances associated with advanced liver disease account for 70% of total hepatic vascular resistance.
*  Functional abnormalities such as endothelial dysfunction and increased hepatic vascular tone account for 30% of total hepatic vascular resistance.
Pathogenesis of Cirrhosis due to Alcohol:
* More than 66 percent of all American adults consume alcohol.
* Cirrhosis due to alcohol accounts for approximately forty percent of mortality rates due to cirrhosis.
* Mechanisms of alcohol-induced damage include:
** Impaired protein synthesis, secretion, glycosylation
* Ethanol intake leads to elevated accumulation of intracellular triglycerides by:
** Lipoprotein secretion
** Decreased fatty acid oxidation
** Increased fatty acid uptake
* Alcohol is converted by Alcohol dehydrogenase to acetaldehyde.
* Due to the high reactivity of acetaldehyde, it forms acetaldehyde-protein adducts which cause damage to cells by:
** Trafficking of hepatic proteins
** Interrupting microtubule formation
** Interfering with enzyme activities
* Damage of hepatocytes leads to the formation of reactive oxygen species that activate Kupffer cells.<ref name="pmid11984538">{{cite journal |vauthors=Arthur MJ |title=Reversibility of liver fibrosis and cirrhosis following treatment for hepatitis C |journal=Gastroenterology |volume=122 |issue=5 |pages=1525–8 |year=2002 |pmid=11984538 |doi= |url=}}</ref>
*Kupffer cell activation leads to the production of profibrogenic cytokines that stimulates stellate cells.
*Stellate cell activation leads to the production of extracellular matrix and collagen.
* Portal triads develop connections with central veins due to connective tissue formation in pericentral and periportal zones, leading to the formation of regenerative nodules.
* Shrinkage of the liver occurs over years due to repeated insults that lead to:
** Loss of hepatocytes
** Increased production and deposition of collagen


 
===Pathophysiology prev===
Pathology
<div style="-webkit-user-select: none;">
* There are four stages of Cirrhosis as it progresses:
{| class="infobox" style="position: fixed; top: 65%; right: 10px; margin: 0 0 0 0; border: 0; float: right;"
** Chronic nonsuppurative destructive cholangitis - inflammation and necrosis of portal tracts with lymphocyte infiltration leading to the destruction of the bile ducts.
** Development of biliary stasis and fibrosis
*Periportal fibrosis progresses to bridging fibrosis
*Increased proliferation of smaller bile ductules leading to regenerative nodule formation.
 
 
 
===Causes===
{| class="wikitable"
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Drugs and Toxins
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Infections
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Autoimmune
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Metabolic
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Biliary obstruction(Secondary bilary cirrhosis)
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Vascular
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Miscellaneous
|-
|-
|Alcohol
| {{#ev:youtube|https://https://www.youtube.com/watch?v=5szNmKtyBW4|350}}
|Hepatitis B
|Primary Biliary Cirrhosis
|Wilson's disease
|Cystic fibrosis
|Chronic RHF
|Sarcoidosis
|-
|-
|Methotrexate
|Hepatitis C
|Autoimmune hepatitis
|Hemochromatosis
|Biliary atresia
|Budd-Chiari syndrome
|Intestinal
bypass operations for obesity
|-
|Isoniazid
|Schistosoma japonicum
|Primary Sclerosing Cholangitis
|Alpha-1 antitrypsin deficiency
|Bile duct strictures
|Veno-occlusive disease
|Cryptogenic: unknown
|-
|Methyldopa
|
|
|Porphyria
|Gallstones
|
|
|-
|
|
|
|Glycogen storage diseases  (such as Galactosaemia, Abetalipoproteinaemia)
|
|
|
|}
|}
__NOTOC__
{{Cirrhosis}}
{{CMG}} {{AE}}


==Video codes==
==Video codes==
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===Normal video===
===Normal video===
{{#ev:youtube|x6e9Pk6inYI}}
{{#ev:youtube|x6e9Pk6inYI}}
{{#ev:youtube|4uSSvD1BAHg}}
{{#ev:youtube|PQXb5D-5UZw}}
{{#ev:youtube|UVJYQlUm2A8}}


===Video in table===
===Video in table===
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===Image and text to the right===
===Image and text to the right===


<figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline>[[File:Global distribution of leptospirosis.jpg|577x577px]]</figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline> Recent out break of leptospirosis is reported in Bronx, New York and found 3 cases in the months January and February, 2017.  
<figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline>[[File:Global distribution of leptospirosis.jpg|577x577px]]</figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline> Recent out break of leptospirosis is reported in Bronx, New York and found 3 cases in the months January and February, 2017.  


===Gallery===
===Gallery===
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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Gastroenterology]]
[[Category:Hepatology]]
[[Category:Disease]]
{{WS}}
{{WS}}
{{WH}}
{{WH}}
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REFERENCES
REFERENCES
<references />
<references />
[[Category:Gastroenterology]]
[[Category:Needs overview]]
[[Category:Hepatology]]
[[Category:Disease]]

Latest revision as of 00:04, 30 July 2020

Physical examination

References

Template:WH Template:WS

References


Pathophysiology prev

https://https://www.youtube.com/watch?v=5szNmKtyBW4%7C350}}

Cirrhosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cirrhosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Tertiary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case studies

Case #1

Sandbox:Cherry On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Sandbox:Cherry

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Sandbox:Cherry

CDC on Sandbox:Cherry

Sandbox:Cherry in the news

Blogs on Sandbox:Cherry

Directions to Hospitals Treating Cirrhosis

Risk calculators and risk factors for Sandbox:Cherry

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:


Pathophysiology prev

https://https://www.youtube.com/watch?v=5szNmKtyBW4%7C350}}

Cirrhosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cirrhosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Tertiary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case studies

Case #1

Sandbox:Cherry On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Sandbox:Cherry

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Sandbox:Cherry

CDC on Sandbox:Cherry

Sandbox:Cherry in the news

Blogs on Sandbox:Cherry

Directions to Hospitals Treating Cirrhosis

Risk calculators and risk factors for Sandbox:Cherry

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2] Associate Editor(s)-in-Chief:

History and Symptoms

  • History should include:
    • Appearance of bowel movements
    • Travel history
    • Associated symptoms
    • Immune status
    • Woodland exposure

References

Template:WH Template:WS

Other Imaging Findings

Other diagnostic studies

Other Diagnostic Studies

  • Breath hydrogen test

==

Overview

References

Template:WH Template:WS

Pathophysiology prev

https://https://www.youtube.com/watch?v=5szNmKtyBW4%7C350}}

Cirrhosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cirrhosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Tertiary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case studies

Case #1

Sandbox:Cherry On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Sandbox:Cherry

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Sandbox:Cherry

CDC on Sandbox:Cherry

Sandbox:Cherry in the news

Blogs on Sandbox:Cherry

Directions to Hospitals Treating Cirrhosis

Risk calculators and risk factors for Sandbox:Cherry

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3] Associate Editor(s)-in-Chief:

Video codes

Normal video

{{#ev:youtube|x6e9Pk6inYI}} {{#ev:youtube|4uSSvD1BAHg}} {{#ev:youtube|PQXb5D-5UZw}} {{#ev:youtube|UVJYQlUm2A8}}

Video in table

{{#ev:youtube|5ucSlgqGAno}}

Floating video

Title
https://https://www.youtube.com/watch?v=ypYI_lmLD7g%7C350}}

Redirect

  1. REDIRECTEsophageal web

synonym website

https://mq.b2i.sg/snow-owl/#!terminology/snomed/10743008

Image

Normal versus Abnormal Barium study of esophagus with varices


Image to the right

C. burnetii, the Q fever causing agent
C. burnetii, the Q fever causing agent

Image and text to the right

<figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline><figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline></figure-inline> Recent out break of leptospirosis is reported in Bronx, New York and found 3 cases in the months January and February, 2017.

Gallery

References

  1. 1.0 1.1 1.2 Neuroendocrine tumor of the pancreas. Libre Pathology. http://librepathology.org/wiki/index.php/Neuroendocrine_tumour_of_the_pancreas

Template:WS Template:WH


REFERENCES