Erysipelas medical therapy: Difference between revisions

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Latest revision as of 21:39, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S. Maliha Shakil, M.D. [2]

Overview

The mainstay of therapy for erysipelas is antimicrobial therapy. Pharmacologic therapy for erysipelas includes either Penicillins, Erythromycin, or Cephalosporins. Empiric therapy for facial erysipelas includes either Vancomycin, Daptomycin, or Linezolid.

Medical Therapy

Antimicrobial Regimen

Erysipelas^[1]

1. Adults

Preferred regimen (1): Penicillin 500 mg PO qid
Preferred regimen (2): Amoxicillin 500 mg PO qid
Preferred regimen (3): Erythromycin 250 mg PO qid
Preferred regimen (4): Ceftriaxone 1 g IV q24h
Preferred regimen (5): Cefazolin 1 to 2 g IV q8h

2. Pediatrics

Preferred regimen (1): Penicillin 25 to 50 mg/kg/day PO tid or qid
Preferred regimen (2): Amoxicillin 25 to 50 mg/kg/day PO tid
Preferred regimen (3): Erythromycin 30 to 50 mg/kg/day PO bid to qid
Preferred regimen (4): Ceftriaxone 50 to 75 mg/kg/day IV q12-24h
Preferred regimen (5): Cefazolin 100 mg/kg/day IV q8h

Facial erysipelas^[2]

1. Causative pathogens

Staphylococcus aureus
Streptococcus spp. (Group A, B, C, & G)
Enterobacteriaceae
Clostridium spp.

2. Empiric antimicrobial therapy

Preferred regimen: Vancomycin 1 g IV q12h
Alternative regimen: Daptomycin 4 mg/kg IV q24h OR Linezolid 600 mg IV q12h

References

↑ Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL; et al. (2014). "Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America". Clin Infect Dis. 59 (2): 147–59. doi:10.1093/cid/ciu296. PMID 24947530.
↑ Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.

Template:WS Template:WH

[pmid24947530-1] Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL; et al. (2014). "Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America". Clin Infect Dis. 59 (2): 147–59. doi:10.1093/cid/ciu296. PMID 24947530.

[2] Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.

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[2]

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 __NOTOC__
+{{Erysipelas}}
+{{CMG}}; {{AE}} {{LRO}} {{Maliha}}
-{{Erysipelas}}
+==Overview==
-Please help WikiDoc by adding more content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
+The mainstay of therapy for erysipelas is [[antimicrobial]] therapy.  Pharmacologic therapy for erysipelas includes either [[Penicillins]], [[Erythromycin]], or [[Cephalosporins]].  Empiric therapy for facial erysipelas includes either [[Vancomycin]], [[Daptomycin]], or [[Linezolid]].
+==Medical Therapy==
+===Antimicrobial Regimen===
+* Erysipelas<ref name="pmid24947530">{{cite journal| author=Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL et al.| title=Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. | journal=Clin Infect Dis | year= 2014 | volume= 59 | issue= 2 | pages= 147-59 | pmid=24947530 | doi=10.1093/cid/ciu296 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24947530  }} </ref>
+:* 1. '''Adults'''
+::* Preferred regimen (1): [[Penicillin]] 500 mg PO qid
+::* Preferred regimen (2): [[Amoxicillin]] 500 mg PO qid
+::* Preferred regimen (3): [[Erythromycin]] 250 mg PO qid
+::* Preferred regimen (4): [[Ceftriaxone]] 1 g IV q24h
+::* Preferred regimen (5): [[Cefazolin]] 1 to 2 g IV q8h
+:* 2. '''Pediatrics'''
+::* Preferred regimen (1): [[Penicillin]] 25 to 50 mg/kg/day PO tid or qid
+::* Preferred regimen (2): [[Amoxicillin]] 25 to 50 mg/kg/day PO tid
+::* Preferred regimen (3): [[Erythromycin]] 30 to 50 mg/kg/day PO bid to qid
+::* Preferred regimen (4): [[Ceftriaxone]] 50 to 75 mg/kg/day IV q12-24h
+::* Preferred regimen (5): [[Cefazolin]] 100 mg/kg/day IV q8h
+*'''Facial erysipelas'''<ref>{{cite book | last = Gilbert | first = David | title = The Sanford guide to antimicrobial therapy | publisher = Antimicrobial Therapy | location = Sperryville, Va | year = 2015 | isbn = 978-1930808843 }}</ref>
+:* '''1. Causative pathogens'''
+::* Staphylococcus aureus
+::* Streptococcus spp. (Group A, B, C, & G)
+::* Enterobacteriaceae
+::* Clostridium spp.
+:* '''2. Empiric antimicrobial therapy'''
+::* Preferred regimen: [[Vancomycin]] 1 g IV q12h
+::* Alternative regimen: [[Daptomycin]] 4 mg/kg IV q24h {{or}} [[Linezolid]] 600 mg IV q12h
-{{CMG}}
-==Overview==
-Depending on the severity, treatment involves either oral or intravenous antibiotics, using [[penicillin]]s, clindamycin or [[erythromycin]]. While illness symptoms resolve in a day or two, the skin may take weeks to return to normal.
 ==References==
+{{Reflist|2}}
-{{Reflist|2}}
+{{WS}}
-[[Category:Needs content]]
+{{WH}}
+[[Category:Dermatology]]
+[[Category:FinalQCRequired]]
+[[Category:Emergency medicine]]
 [[Category:Disease]]
+[[Category:Up-To-Date]]
 [[Category:Infectious disease]]
-[[Category:Dermatology]]