Celiac disease causes: Difference between revisions

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{{Celiac disease}}
{{Celiac disease}}
{{CMG}}; {{AE}}  
{{CMG}}; {{AE}} {{MMF}}
==Overview==
==Overview==
Disease name] may be caused by [cause1], [cause2], or [cause3].


OR
The common causes of celiac disease are [[autoantibodies]] to [[gluten]] and certain [[HLA-DQ|genetic factors]].
 
Common causes of [disease] include [cause1], [cause2], and [cause3].
 
OR
 
The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
 
OR
 
The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click [[Pericarditis causes#Overview|here]].


==Causes==
==Causes==
===Life-threatening Causes===
The common causes of celiac disease are [[autoantibodies]] to [[gluten]] and certain [[HLA-DQ|genetic factors]].<ref name="pmid19394538">{{cite journal |vauthors=Di Sabatino A, Corazza GR |title=Coeliac disease |journal=Lancet |volume=373 |issue=9673 |pages=1480–93 |year=2009 |pmid=19394538 |doi=10.1016/S0140-6736(09)60254-3 |url=}}</ref><ref name="pmid19443237">{{cite journal |vauthors=Heap GA, van Heel DA |title=Genetics and pathogenesis of coeliac disease |journal=Semin. Immunol. |volume=21 |issue=6 |pages=346–54 |year=2009 |pmid=19443237 |doi=10.1016/j.smim.2009.04.001 |url=}}</ref>
*Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
*[Cause] is a life-threatening cause of [disease].
===Common Causes===
===Common Causes===
Celiac disease may be caused by:
Celiac disease is usually caused by:
*Wheat
*Autoantibodies against gluten which is found in:
*Barley
**[[Wheat]]
*Rye
**Barley
 
**Rye
 
===Less Common Causes===
Less common causes of [[disease name]] include:
*[Cause1]
*[Cause2]
*[Cause3]


===Genetic Causes===
===Genetic Causes===
*[Disease name] is caused by a mutation in the [gene name] gene.
*Celiac disease is linked to the [[HLA]] genes usually [[HLA DQ|HLA DQ2]] and [[HLA DQ|HLA DQ8]].
 
**CELIAC1 (6p21)
===Causes by Organ System===
*Non-HLA genes are also thought to be related to celiac disease:
 
**CELIAC2 (5q31-33)
{|style="width:80%; height:100px" border="1"
**CELIAC3 (2q33)
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
**CELIAC4 (19p13·1)
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
|-
|}
 
 
===Causes in Alphabetical Order===
List the causes of the disease in alphabetical order.
{{columns-list|3|
* Cause 1
* Cause 2
* Cause 3
* Cause 4
* Cause 5
* Cause 6
* Cause 7
* Cause 8
* Cause 9
* Cause 10
}}


==References==
==References==
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[[Category:Disease]]
[[Category:Disease]]
[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[Category:Primary care]]
[[Category:Rheumatology]]
[[Category:Rheumatology]]
[[Category:Autoimmune diseases]]
[[Category:Autoimmune diseases]]
[[Category:Gastroenterology]]
[[Category:Genetic disorders]]
[[Category:Genetic disorders]]
[[Category:Malnutrition]]
[[Category:Malnutrition]]
[[Category:Pediatrics]]
[[Category:Pediatrics]]
[[Category:Dermatology]]
[[Category:Dermatology]]
[[Category:Primary care]]
[[Category:Up-To-Date]]
[[Category:Up-To-Date]]

Latest revision as of 20:50, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.

Causes

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.[1][2]

Common Causes

Celiac disease is usually caused by:

  • Autoantibodies against gluten which is found in:

Genetic Causes

  • Celiac disease is linked to the HLA genes usually HLA DQ2 and HLA DQ8.
    • CELIAC1 (6p21)
  • Non-HLA genes are also thought to be related to celiac disease:
    • CELIAC2 (5q31-33)
    • CELIAC3 (2q33)
    • CELIAC4 (19p13·1)

References

  1. ↑ Di Sabatino A, Corazza GR (2009). "Coeliac disease". Lancet. 373 (9673): 1480–93. doi:10.1016/S0140-6736(09)60254-3. PMID 19394538.
  2. ↑ Heap GA, van Heel DA (2009). "Genetics and pathogenesis of coeliac disease". Semin. Immunol. 21 (6): 346–54. doi:10.1016/j.smim.2009.04.001. PMID 19443237.

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