Follicular thyroid cancer natural history, complications and prognosis: Difference between revisions

	Follicular thyroid cancer Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Follicular thyroid cancer from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
X-ray
Echocardiography and Ultrasound
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Follicular thyroid cancer natural history, complications and prognosis On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Follicular thyroid cancer natural history, complications and prognosis All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Follicular thyroid cancer natural history, complications and prognosis
CDC on Follicular thyroid cancer natural history, complications and prognosis
Follicular thyroid cancer natural history, complications and prognosis in the news
Blogs on Follicular thyroid cancer natural history, complications and prognosis
Directions to Hospitals Treating Follicular thyroid cancer
Risk calculators and risk factors for Follicular thyroid cancer natural history, complications and prognosis

VisualWikitext

Latest revision as of 17:31, 29 October 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Depending on the extent of the tumor at the time of diagnosis, prognosis of follicular thyroid cancer may vary. However, prognosis is generally regarded as good. The presence of metastasis is associated with a particularly poor prognosis among patients with follicular thyroid cancer.

Natural History, Complications, and Prognosis

Natural History

Natural history of follicular thyroid cancer is variable.
Symptoms of follicular thyroid cancer usually develop in the fourth decade of life.
The condition presents as a slowly enlarging painless mass.
Without treatment, patients will develop symptoms caused by compression and metastasis, such as hoarseness of voice, difficulty swallowing, and difficulty breathing.^[1]

Complications

Common complications of follicular thyroid cancer include:^[2]

Prognosis

Prognosis of follicular thyroid cancer is directly related to tumor size.^[3]
- Good Prognostic Factors:
  - Children
  - Adolescent
  - Women younger than 50
  - Men younger than 40
- Bad Prognostic Factors:
  - Women older than 50 with follicular carcinoma
  - Men older than 40 with follicular carcinoma
  - Distant metastasis
  - Large tumor size
  - Extensive vascular invasion
  - Extra thyroidal extension
  - Widely invasive tumors
Stage Related Prognosis
- The 10-year survival is better for patients with follicular carcinoma without vascular invasion than it is for patients with vascular invasion.
- Follicular carcinoma invading the cervical tissue has a worse prognosis than tumors confined to the thyroid gland.
- The presence of vascular invasion is an additional poor prognostic factor.
- Metastasis to lymph nodes do not worsen the prognosis in patients younger than 45 years.
- The prognosis for patients with distant metastases is poor.

5-year Relative Survival Rate
- 5-year relative survival rate of follicular thyroid cancer depends on the stage of the disease at the time of diagnosis.
  - Stage 1 has 100% 5-year relative survival rate.
  - Stage 2 has 100% 5-year relative survival rate.
  - Stage 3 has 71% 5-year relative survival rate.
  - Stage 4 has 50% 5-year relative survival rate.

References

↑ Thyroid Cancer Cancer.gov (2015). http://www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq#section/_6- Accessed on October, 29 2015
↑ Emerick GT, Duh QY, Siperstein AE, Burrow GN, Clark OH (December 1993). "Diagnosis, treatment, and outcome of follicular thyroid carcinoma". Cancer. 72 (11): 3287–95. doi:10.1002/1097-0142(19931201)72:11<3287::aid-cncr2820721126>3.0.co;2-5. PMID 8080485.
↑ Grebe SK, Hay ID (December 1995). "Follicular thyroid cancer". Endocrinol. Metab. Clin. North Am. 24 (4): 761–801. PMID 8608779.

[1] Thyroid Cancer Cancer.gov (2015). http://www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq#section/_6- Accessed on October, 29 2015

[pmid8080485-2] Emerick GT, Duh QY, Siperstein AE, Burrow GN, Clark OH (December 1993). "Diagnosis, treatment, and outcome of follicular thyroid carcinoma". Cancer. 72 (11): 3287–95. doi:10.1002/1097-0142(19931201)72:11<3287::aid-cncr2820721126>3.0.co;2-5. PMID 8080485.

[pmid8608779-3] Grebe SK, Hay ID (December 1995). "Follicular thyroid cancer". Endocrinol. Metab. Clin. North Am. 24 (4): 761–801. PMID 8608779.

[1]

[2]

[3]

@@ Line 3: / Line 3: @@
 {{CMG}}; {{AE}} {{Ammu}}
 ==Overview==
-Depending on the extent of the tumor at the time of diagnosis, the prognosis of follicular thyroid cancer may vary. However, the prognosis is generally regarded as poor. The presence of metastasis is associated with a particularly poor prognosis among patients with follicular thyroid cancer.
+Depending on the extent of the [[tumor]] at the time of [[diagnosis]], [[prognosis]] of follicular thyroid cancer may vary. However, [[prognosis]] is generally regarded as good. The presence of [[metastasis]] is associated with a particularly poor [[prognosis]] among [[Patient|patients]] with follicular thyroid cancer.
-==Natural History==
+==Natural History, Complications, and Prognosis==
-The natural history of follicular thyroid cancer is variable. The symptoms of follicular thyroid cancer usually develop in the fourth decade of life, and start with symptoms such as a slowly enlarging painless mass. Without treatment, the patient will develop symptoms of compression and metastasis such as hoarseness of voice, dysphagia, and dyspnea.
-==Complications==
+=== Natural History ===
-* Metastasis
-* Hoarseness of voice
+* Natural history of follicular thyroid cancer is variable.
-* Dysphagia
+* [[Symptoms]] of follicular thyroid cancer usually develop in the fourth decade of life.
-* Dyspnea
+* The condition presents as a slowly enlarging [[Pain|painless]] mass.
-==Prognosis==
+* Without treatment, [[Patient|patients]] will develop [[Symptom|symptoms]] caused by [[compression]] and [[metastasis]], such as [[dysphonia|hoarseness of voice]], [[dysphagia|difficulty swallowing]], and [[dyspnea|difficulty breathing]].<ref> Thyroid Cancer Cancer.gov
-* Prognosis of follicular thyroid cancer is directly related to tumor size.
+(2015). http://www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq#section/_6- Accessed on October, 29 2015</ref>
-====<span style="color:red">Worst Prognostic Factors</span>====
-* Women older than 50 with follicular carcinoma
+===Complications===
-* Men older than 40 with follicular carcinoma
+Common complications of follicular thyroid cancer include:<ref name="pmid8080485">{{cite journal |vauthors=Emerick GT, Duh QY, Siperstein AE, Burrow GN, Clark OH |title=Diagnosis, treatment, and outcome of follicular thyroid carcinoma |journal=Cancer |volume=72 |issue=11 |pages=3287–95 |date=December 1993 |pmid=8080485 |doi=10.1002/1097-0142(19931201)72:11<3287::aid-cncr2820721126>3.0.co;2-5 |url=}}</ref>
-* Distant metastasis
+* [[Metastasis]]
-* Large tumor size
+* [[dysphonia|Hoarseness of voice]]
-* Extensive vascular invasion
+* [[Dysphagia]]
-* Extra thyroidal extension
+* [[Dyspnea]]
-* Widely invasive tumors
-====<span style="color:red">Intermediate Prognostic Factors</span>====
+===Prognosis===
-* Women older than 50 with papillary carcinoma
+*[[Prognosis]] of follicular thyroid cancer is directly related to [[tumor]] size.<ref name="pmid8608779">{{cite journal |vauthors=Grebe SK, Hay ID |title=Follicular thyroid cancer |journal=Endocrinol. Metab. Clin. North Am. |volume=24 |issue=4 |pages=761–801 |date=December 1995 |pmid=8608779 |doi= |url=}}</ref>
-* Men older than 40 with papillary carcinoma
+**'''Good Prognostic Factors''':
-====<span style="color:red">Good Prognostic Factors</span>====
+***[[Child|Children]]
-* Children
+***[[Adolescence|Adolescent]]
-* Adolescent
+***[[Female|Women]] younger than 50
-* Women younger than 50
+***[[Men]] younger than 40
-* Men younger than 40
+**'''Bad Prognostic Factors''':
-===5 year Relative Survival Rate===
+***[[Female|Women]] older than 50 with follicular carcinoma
-* 5 year relative survival rate of follicular thyroid cancer depends on the stage of the disease at the time of diagnosis.
+***[[Men]] older than 40 with follicular carcinoma
-* Stage 1 has 100% 5 year relative survival rate
+***Distant [[metastasis]]
-* Stage 2 has 100% 5 year relative survival rate
+***Large [[tumor]] size
-* Stage 3 has 71% 5 year relative survival rate
+*** Extensive [[vascular]] [[Invasive (medical)|invasion]]
-* Stage 4 has 50% 5 year relative survival rate
+*** Extra [[Thyroid|thyroidal]] extension
+*** Widely [[Invasive (medical)|invasive]] [[Tumor|tumors]]
+*'''Stage Related Prognosis'''
+** The 10-year [[Survival rate|survival]] is better for [[Patient|patients]] with follicular carcinoma without [[vascular]] [[Invasive (medical)|invasion]] than it is for [[Patient|patients]] with [[vascular]] [[Invasive (medical)|invasion]].
+** Follicular carcinoma invading the [[cervical]] [[Tissue (biology)|tissue]] has a worse [[prognosis]] than [[tumors]] confined to the [[thyroid gland]].
+**The presence of [[vascular]] [[Invasive (medical)|invasion]] is an additional poor [[Prognosis|prognostic]] factor.
+**[[Metastasis]] to [[Lymph node|lymph nodes]] do not worsen the [[prognosis]] in [[Patient|patients]] younger than 45 years.
+** The [[prognosis]] for [[Patient|patients]] with distant [[Metastasis|metastases]] is poor.
+*'''5-year Relative Survival Rate'''
+**5-year relative [[survival rate]] of follicular thyroid cancer depends on the [[Cancer staging|stage]] of the [[disease]] at the time of [[diagnosis]].
+*** Stage 1 has 100% 5-year relative [[survival rate]].
+*** Stage 2 has 100% 5-year relative [[survival rate]].
+*** Stage 3 has 71% 5-year relative [[survival rate]].
+*** Stage 4 has 50% 5-year relative [[survival rate]].
 ==References==