Primary cutaneous follicle centre lymphoma epidemiology and demographics: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
According to a large population-based study focused on cutaneous lymphomas (CL) in the United States by Bradford et al. on 3884 Cutaneous lymphomas 9CLs) diagnosed during 2001-2005. Cutaneous T-cell lymphomas (CTCLs) accounted for 71% (age-adjusted incidence rate [IR] = 7.7/1 000 000 person-years), whereas cutaneous B-cell lymphomas(CBCLs) accounted for 29% (IR = 3.1/1 000 000 person-years).<ref name="pmid19279331">{{cite journal| author=Bradford PT, Devesa SS, Anderson WF, Toro JR| title=Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases. | journal=Blood | year= 2009 | volume= 113 | issue= 21 | pages= 5064-73 | pmid=19279331 | doi=10.1182/blood-2008-10-184168 | pmc=2686177 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19279331 }} </ref> | According to a large population-based study focused on cutaneous lymphomas (CL) in the United States by Bradford et al. on 3884 Cutaneous lymphomas 9CLs) diagnosed during 2001-2005. Cutaneous T-cell lymphomas (CTCLs) accounted for 71% (age-adjusted incidence rate [IR] = 7.7/1 000 000 person-years), whereas cutaneous B-cell lymphomas(CBCLs) accounted for 29% (IR = 3.1/1 000 000 person-years).<ref name="pmid19279331">{{cite journal| author=Bradford PT, Devesa SS, Anderson WF, Toro JR| title=Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases. | journal=Blood | year= 2009 | volume= 113 | issue= 21 | pages= 5064-73 | pmid=19279331 | doi=10.1182/blood-2008-10-184168 | pmc=2686177 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19279331 }} </ref> | ||
===Incidence=== | ===Incidence=== | ||
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* During 2004-2005, the CL IR was 12.7. This recent apparent change could be incomplete case ascertainment or potential levelling off of incidence rates. | * During 2004-2005, the CL IR was 12.7. This recent apparent change could be incomplete case ascertainment or potential levelling off of incidence rates. | ||
* CLs rates vary markedly by race and sex, supporting the notion that they represent distinct disease entities. | * CLs rates vary markedly by race and sex, supporting the notion that they represent distinct disease entities. | ||
=== Prevalence === | === Prevalence === | ||
* There is no prevalence report primary cutaneous follicle centre lymphoma | * There is no prevalence report primary cutaneous follicle centre lymphoma. | ||
*Primary cutaneous follicle center lymphoma is the most common primary cutaneous B-cell lymphoma. | |||
*It accounts for approximately 10% to 20% of all cutaneous lymphomas and comprises about 50% of primary cutaneous B-cell lymphomas. | |||
=== Case-fatality rate/Mortality rate === | === Case-fatality rate/Mortality rate === | ||
* | * The case-fatality rate/mortality rate of primary cutaneous follicle centre lymphoma is quite low. | ||
* The | *Spread from the skin is unusual, and the prognosis is excellent with a 5-year survival of over 97%. | ||
*The International Extranodal Lymphoma Study Group identified elevated LDH, more than two skin lesions, and nodular lesions as three prognostic factors, that are used to assess a cutaneous lymphoma international prognostic index (CLIPI), which is prognostic of disease-free status. | |||
=== Age === | === Age === | ||
The incidence of primary cutaneous follicle centre lymphoma increases with age; the median age at diagnosis is 51 years.<ref name="cancer.gov" /> | |||
* The incidence of primary cutaneous follicle centre lymphoma increases with age; the median age at diagnosis is 51 years.<ref name="cancer.gov" /> | |||
* Most commonly, patients are white men, 50 to 60 years old, although younger patients and women may also develop this lymphoma. | |||
* | * | ||
| Line 54: | Line 47: | ||
=== Region === | === Region === | ||
* | * Theoretically, and according to some studies primary cutaneous follicle centre lymphoma cases are more reported in areas of increased prevalence of the following pathogenes: | ||
** [[Borrelia burgdorferi]] | |||
** [[Hepatitis C]] | |||
** [[Human herpesvirus 8]] <br /> | |||
* primary cutaneous follicle centre lymphoma | *Specifically, the region of southeast Asian countries have a presumable high incidence of cutaneous T cell Lymphoma(CTCL), in particular, Epstein-Baar virus-associated natural killer/T-cell lymphomas, while Cutaneous B cell lymphomas (CBCL) are very uncommon.<ref name="pmid29422831">{{cite journal| author=Petković IZ, Pejčić I, Tiodorović D, Krstić M, Stojnev S, Vrbić S| title=Transformation of primary cutaneous follicle centre lymphoma into primary cutaneous diffuse large B-cell lymphoma of other type. | journal=Postepy Dermatol Alergol | year= 2017 | volume= 34 | issue= 6 | pages= 625-628 | pmid=29422831 | doi=10.5114/pdia.2017.66625 | pmc=5799751 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29422831 }} </ref> | ||
=== Developed Countries === | === Developed Countries === | ||
Latest revision as of 22:59, 24 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2] Soroush Seifirad, M.D.[3]
Overview
The incidence of primary cutaneous follicle centre lymphoma increases with age; the median age at diagnosis is 51 years. Males are more commonly affected with primary cutaneous follicle centre lymphoma than females.[1]
Epidemiology and Demographics
According to a large population-based study focused on cutaneous lymphomas (CL) in the United States by Bradford et al. on 3884 Cutaneous lymphomas 9CLs) diagnosed during 2001-2005. Cutaneous T-cell lymphomas (CTCLs) accounted for 71% (age-adjusted incidence rate [IR] = 7.7/1 000 000 person-years), whereas cutaneous B-cell lymphomas(CBCLs) accounted for 29% (IR = 3.1/1 000 000 person-years).[2]
Incidence
- Over the past 25 years, the CL incidence rate increased from 5.0/1 000 000 person-years during 1980-1982 to 14.3 during 2001-2003.
- During 2004-2005, the CL IR was 12.7. This recent apparent change could be incomplete case ascertainment or potential levelling off of incidence rates.
- CLs rates vary markedly by race and sex, supporting the notion that they represent distinct disease entities.
Prevalence
- There is no prevalence report primary cutaneous follicle centre lymphoma.
- Primary cutaneous follicle center lymphoma is the most common primary cutaneous B-cell lymphoma.
- It accounts for approximately 10% to 20% of all cutaneous lymphomas and comprises about 50% of primary cutaneous B-cell lymphomas.
Case-fatality rate/Mortality rate
- The case-fatality rate/mortality rate of primary cutaneous follicle centre lymphoma is quite low.
- Spread from the skin is unusual, and the prognosis is excellent with a 5-year survival of over 97%.
- The International Extranodal Lymphoma Study Group identified elevated LDH, more than two skin lesions, and nodular lesions as three prognostic factors, that are used to assess a cutaneous lymphoma international prognostic index (CLIPI), which is prognostic of disease-free status.
Age
- The incidence of primary cutaneous follicle centre lymphoma increases with age; the median age at diagnosis is 51 years.[1]
- Most commonly, patients are white men, 50 to 60 years old, although younger patients and women may also develop this lymphoma.
Race
- Primary cutaneous follicle centre lymphoma usually affects individuals of the blacks and non-Hispanic whites followed by Hispanic whites and Asian/Pacific Islanders . Whites of European descent individuals are less likely to develop primary cutaneous follicle centre lymphoma.
- According to Bradford et al. CL incidence rate were highest among blacks and non-Hispanic whites (both 11.5/1 000 000 person-years), followed by Hispanic whites (7.9) and Asian/Pacific Islanders (7.1). The CTCL IR was highest among blacks (10.0/1 000 000 person-years), whereas the CBCL IR was highest among non-Hispanic whites (3.5).[2]
Gender
Males are more commonly affected with primary cutaneous follicle centre lymphoma than females.[1]
According to Bradford et al. also, males had a statistically significant higher incidence of CL than females (14.0 vs 8.2/1 000 000 person-years, respectively; male-female IR ratio [M/F IRR] = 1.72; P < .001).[2]
Region
- Theoretically, and according to some studies primary cutaneous follicle centre lymphoma cases are more reported in areas of increased prevalence of the following pathogenes:
- Specifically, the region of southeast Asian countries have a presumable high incidence of cutaneous T cell Lymphoma(CTCL), in particular, Epstein-Baar virus-associated natural killer/T-cell lymphomas, while Cutaneous B cell lymphomas (CBCL) are very uncommon.[3]
Developed Countries
Developing Countries
References
- ↑ 1.0 1.1 1.2 Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 01, 2016
- ↑ 2.0 2.1 2.2 Bradford PT, Devesa SS, Anderson WF, Toro JR (2009). "Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases". Blood. 113 (21): 5064–73. doi:10.1182/blood-2008-10-184168. PMC 2686177. PMID 19279331.
- ↑ Petković IZ, Pejčić I, Tiodorović D, Krstić M, Stojnev S, Vrbić S (2017). "Transformation of primary cutaneous follicle centre lymphoma into primary cutaneous diffuse large B-cell lymphoma of other type". Postepy Dermatol Alergol. 34 (6): 625–628. doi:10.5114/pdia.2017.66625. PMC 5799751. PMID 29422831.